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Items: 1 to 20 of 52

1.

Orexin receptor antagonism, a new sleep-promoting paradigm: an ascending single-dose study with almorexant.

Hoever P, de Haas S, Winkler J, Schoemaker RC, Chiossi E, van Gerven J, Dingemanse J.

Clin Pharmacol Ther. 2010 May;87(5):593-600. doi: 10.1038/clpt.2010.19. Epub 2010 Apr 7.

PMID:
20376002
2.

Algorithms for the assessment and management of insomnia in primary care.

Hilty D, Young JS, Bourgeois JA, Klein S, Hardin KA.

Patient Prefer Adherence. 2009 Nov 3;3:9-20.

3.

Orexin/hypocretin and histamine: distinct roles in the control of wakefulness demonstrated using knock-out mouse models.

Anaclet C, Parmentier R, Ouk K, Guidon G, Buda C, Sastre JP, Akaoka H, Sergeeva OA, Yanagisawa M, Ohtsu H, Franco P, Haas HL, Lin JS.

J Neurosci. 2009 Nov 18;29(46):14423-38. doi: 10.1523/JNEUROSCI.2604-09.2009.

4.

Comparative tolerability of newer agents for insomnia.

Zammit G.

Drug Saf. 2009;32(9):735-48. doi: 10.2165/11312920-000000000-00000. Review.

PMID:
19670914
5.

Orexins/hypocretins and aminergic systems.

Eriksson KS, Sergeeva OA, Haas HL, Selbach O.

Acta Physiol (Oxf). 2010 Mar;198(3):263-75. doi: 10.1111/j.1748-1716.2009.02015.x. Epub 2009 Jun 27. Review.

PMID:
19566795
6.

Blockade of orexin-1 receptors attenuates orexin-2 receptor antagonism-induced sleep promotion in the rat.

Dugovic C, Shelton JE, Aluisio LE, Fraser IC, Jiang X, Sutton SW, Bonaventure P, Yun S, Li X, Lord B, Dvorak CA, Carruthers NI, Lovenberg TW.

J Pharmacol Exp Ther. 2009 Jul;330(1):142-51. doi: 10.1124/jpet.109.152009. Epub 2009 Apr 10.

7.

Clinical guideline for the evaluation and management of chronic insomnia in adults.

Schutte-Rodin S, Broch L, Buysse D, Dorsey C, Sateia M.

J Clin Sleep Med. 2008 Oct 15;4(5):487-504.

8.

A polysomnographic placebo-controlled evaluation of the efficacy and safety of eszopiclone relative to placebo and zolpidem in the treatment of primary insomnia.

Erman MK, Zammit G, Rubens R, Schaefer K, Wessel T, Amato D, Caron J, Walsh JK.

J Clin Sleep Med. 2008 Jun 15;4(3):229-34.

9.

Nocturnal awakenings and comorbid disorders in the American general population.

Ohayon MM.

J Psychiatr Res. 2008 Nov;43(1):48-54. doi: 10.1016/j.jpsychires.2008.02.001. Epub 2008 Mar 28.

PMID:
18374943
10.
11.

Evaluation of the efficacy and safety of ramelteon in subjects with chronic insomnia.

Zammit G, Erman M, Wang-Weigand S, Sainati S, Zhang J, Roth T.

J Clin Sleep Med. 2007 Aug 15;3(5):495-504. Erratum in: J Clin Sleep Med. 2008 Oct 15;4(5):table of contents. J Clin Sleep Med. 2007 Oct 15;3(6):table of contents.

12.

The efficacy and safety of drug treatments for chronic insomnia in adults: a meta-analysis of RCTs.

Buscemi N, Vandermeer B, Friesen C, Bialy L, Tubman M, Ospina M, Klassen TP, Witmans M.

J Gen Intern Med. 2007 Sep;22(9):1335-50. Epub 2007 Jul 10.

14.

Digital analysis and technical specifications.

Penzel T, Hirshkowitz M, Harsh J, Chervin RD, Butkov N, Kryger M, Malow B, Vitiello MV, Silber MH, Kushida CA, Chesson AL Jr.

J Clin Sleep Med. 2007 Mar 15;3(2):109-20. Review.

PMID:
17557421
15.

The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness.

Sakurai T.

Nat Rev Neurosci. 2007 Mar;8(3):171-81. Epub 2007 Feb 14. Review.

PMID:
17299454
16.

Promotion of sleep by targeting the orexin system in rats, dogs and humans.

Brisbare-Roch C, Dingemanse J, Koberstein R, Hoever P, Aissaoui H, Flores S, Mueller C, Nayler O, van Gerven J, de Haas SL, Hess P, Qiu C, Buchmann S, Scherz M, Weller T, Fischli W, Clozel M, Jenck F.

Nat Med. 2007 Feb;13(2):150-5. Epub 2007 Jan 28.

PMID:
17259994
17.

Efficacy and safety of zolpidem-MR: a double-blind, placebo-controlled study in adults with primary insomnia.

Roth T, Soubrane C, Titeux L, Walsh JK; Zoladult Study Group.

Sleep Med. 2006 Aug;7(5):397-406. Epub 2006 Jul 3.

PMID:
16815744
18.

Orexin A mediation of time spent moving in rats: neural mechanisms.

Kotz CM, Wang C, Teske JA, Thorpe AJ, Novak CM, Kiwaki K, Levine JA.

Neuroscience. 2006 Sep 29;142(1):29-36. Epub 2006 Jun 30.

PMID:
16809007
19.

Roles of orexins and orexin receptors in central regulation of feeding behavior and energy homeostasis.

Sakurai T.

CNS Neurol Disord Drug Targets. 2006 Jun;5(3):313-25. Review.

PMID:
16787231
20.

Sleep maintenance insomnia: strengths and weaknesses of current pharmacologic therapies.

Rosenberg RP.

Ann Clin Psychiatry. 2006 Jan-Mar;18(1):49-56. Review.

PMID:
16517453

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