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The orphan nuclear receptor SHP is a positive regulator of osteoblastic bone formation.

Jeong BC, Lee YS, Bae IH, Lee CH, Shin HI, Ha HJ, Franceschi RT, Choi HS, Koh JT.

J Bone Miner Res. 2010 Feb;25(2):262-74. doi: 10.1359/jbmr.090718.


COUP-TFII acts downstream of Wnt/beta-catenin signal to silence PPARgamma gene expression and repress adipogenesis.

Okamura M, Kudo H, Wakabayashi K, Tanaka T, Nonaka A, Uchida A, Tsutsumi S, Sakakibara I, Naito M, Osborne TF, Hamakubo T, Ito S, Aburatani H, Yanagisawa M, Kodama T, Sakai J.

Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5819-24. doi: 10.1073/pnas.0901676106. Epub 2009 Mar 23.


Identification of COUP-TFII orphan nuclear receptor as a retinoic acid-activated receptor.

Kruse SW, Suino-Powell K, Zhou XE, Kretschman JE, Reynolds R, Vonrhein C, Xu Y, Wang L, Tsai SY, Tsai MJ, Xu HE.

PLoS Biol. 2008 Sep 16;6(9):e227. doi: 10.1371/journal.pbio.0060227.


Orphan nuclear receptor SHP interacts with and represses hepatocyte nuclear factor-6 (HNF-6) transactivation.

Lee YS, Kim DK, Kim YD, Park KC, Shong M, Seong HA, Ha HJ, Choi HS.

Biochem J. 2008 Aug 1;413(3):559-69. doi: 10.1042/BJ20071637.


COUP-TF an orphan member of the steroid/thyroid hormone receptor superfamily.

Qiu Y, Tsai SY, Tsai MJ.

Trends Endocrinol Metab. 1994 Aug;5(6):234-9.


The orphan nuclear receptor chicken ovalbumin upstream promoter-transcription factor II is a critical regulator of adipogenesis.

Xu Z, Yu S, Hsu CH, Eguchi J, Rosen ED.

Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2421-6. doi: 10.1073/pnas.0707082105. Epub 2008 Feb 4.


Structural coupling of Smad and Runx2 for execution of the BMP2 osteogenic signal.

Javed A, Bae JS, Afzal F, Gutierrez S, Pratap J, Zaidi SK, Lou Y, van Wijnen AJ, Stein JL, Stein GS, Lian JB.

J Biol Chem. 2008 Mar 28;283(13):8412-22. doi: 10.1074/jbc.M705578200. Epub 2008 Jan 18.


Orphan nuclear receptors in drug discovery.

Shi Y.

Drug Discov Today. 2007 Jun;12(11-12):440-5. Epub 2007 Apr 26. Review.


Signaling and transcriptional regulation in osteoblast commitment and differentiation.

Huang W, Yang S, Shao J, Li YP.

Front Biosci. 2007 May 1;12:3068-92. Review.


Hypoxia-mediated activation of Dll4-Notch-Hey2 signaling in endothelial progenitor cells and adoption of arterial cell fate.

Diez H, Fischer A, Winkler A, Hu CJ, Hatzopoulos AK, Breier G, Gessler M.

Exp Cell Res. 2007 Jan 1;313(1):1-9. Epub 2006 Sep 19.


COUP-TFII is essential for radial and anteroposterior patterning of the stomach.

Takamoto N, You LR, Moses K, Chiang C, Zimmer WE, Schwartz RJ, DeMayo FJ, Tsai MJ, Tsai SY.

Development. 2005 May;132(9):2179-89.


Molecular mechanism of chicken ovalbumin upstream promoter-transcription factor (COUP-TF) actions.

Park JI, Tsai SY, Tsai MJ.

Keio J Med. 2003 Sep;52(3):174-81. Review.


Regulation of the bone-specific osteocalcin gene by p300 requires Runx2/Cbfa1 and the vitamin D3 receptor but not p300 intrinsic histone acetyltransferase activity.

Sierra J, Villagra A, Paredes R, Cruzat F, Gutierrez S, Javed A, Arriagada G, Olate J, Imschenetzky M, Van Wijnen AJ, Lian JB, Stein GS, Stein JL, Montecino M.

Mol Cell Biol. 2003 May;23(9):3339-51.


Regulation of retinoic acid-induced inhibition of AP-1 activity by orphan receptor chicken ovalbumin upstream promoter-transcription factor.

Lin F, Kolluri SK, Chen GQ, Zhang XK.

J Biol Chem. 2002 Jun 14;277(24):21414-22. Epub 2002 Apr 4.


COUP-TF orphan nuclear receptors in development and differentiation.

Pereira FA, Tsai MJ, Tsai SY.

Cell Mol Life Sci. 2000 Sep;57(10):1388-98. Review.


Groucho/TLE/R-esp proteins associate with the nuclear matrix and repress RUNX (CBF(alpha)/AML/PEBP2(alpha)) dependent activation of tissue-specific gene transcription.

Javed A, Guo B, Hiebert S, Choi JY, Green J, Zhao SC, Osborne MA, Stifani S, Stein JL, Lian JB, van Wijnen AJ, Stein GS.

J Cell Sci. 2000 Jun;113 ( Pt 12):2221-31.


The orphan nuclear receptor COUP-TFII is required for angiogenesis and heart development.

Pereira FA, Qiu Y, Zhou G, Tsai MJ, Tsai SY.

Genes Dev. 1999 Apr 15;13(8):1037-49.

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