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Items: 1 to 20 of 31

1.

Metabolic amplification of insulin secretion by glucose is independent of β-cell microtubules.

Mourad NI, Nenquin M, Henquin JC.

Am J Physiol Cell Physiol. 2011 Mar;300(3):C697-706. doi: 10.1152/ajpcell.00329.2010. Epub 2010 Dec 22.

PMID:
21178111
2.

The pseudokinase tribbles homolog 3 interacts with ATF4 to negatively regulate insulin exocytosis in human and mouse beta cells.

Liew CW, Bochenski J, Kawamori D, Hu J, Leech CA, Wanic K, Malecki M, Warram JH, Qi L, Krolewski AS, Kulkarni RN.

J Clin Invest. 2010 Aug;120(8):2876-88. doi: 10.1172/JCI36849. Epub 2010 Jul 1.

3.

Glucagon-like peptide-1 agonists protect pancreatic beta-cells from lipotoxic endoplasmic reticulum stress through upregulation of BiP and JunB.

Cunha DA, Ladrière L, Ortis F, Igoillo-Esteve M, Gurzov EN, Lupi R, Marchetti P, Eizirik DL, Cnop M.

Diabetes. 2009 Dec;58(12):2851-62. doi: 10.2337/db09-0685. Epub 2009 Aug 31.

4.

Leptin-dependent phosphorylation of PTEN mediates actin restructuring and activation of ATP-sensitive K+ channels.

Ning K, Miller LC, Laidlaw HA, Watterson KR, Gallagher J, Sutherland C, Ashford ML.

J Biol Chem. 2009 Apr 3;284(14):9331-40. doi: 10.1074/jbc.M806774200. Epub 2009 Feb 10.

6.

Disruption of leptin receptor expression in the pancreas directly affects beta cell growth and function in mice.

Morioka T, Asilmaz E, Hu J, Dishinger JF, Kurpad AJ, Elias CF, Li H, Elmquist JK, Kennedy RT, Kulkarni RN.

J Clin Invest. 2007 Oct;117(10):2860-8.

7.

Insulin receptors in beta-cells are critical for islet compensatory growth response to insulin resistance.

Okada T, Liew CW, Hu J, Hinault C, Michael MD, Krtzfeldt J, Yin C, Holzenberger M, Stoffel M, Kulkarni RN.

Proc Natl Acad Sci U S A. 2007 May 22;104(21):8977-82. Epub 2007 Apr 6.

8.
9.

The pancreatic beta cell is a key site for mediating the effects of leptin on glucose homeostasis.

Covey SD, Wideman RD, McDonald C, Unniappan S, Huynh F, Asadi A, Speck M, Webber T, Chua SC, Kieffer TJ.

Cell Metab. 2006 Oct;4(4):291-302.

10.
11.

A novel leptin signalling pathway via PTEN inhibition in hypothalamic cell lines and pancreatic beta-cells.

Ning K, Miller LC, Laidlaw HA, Burgess LA, Perera NM, Downes CP, Leslie NR, Ashford ML.

EMBO J. 2006 Jun 7;25(11):2377-87. Epub 2006 May 4.

12.

Total insulin and IGF-I resistance in pancreatic beta cells causes overt diabetes.

Ueki K, Okada T, Hu J, Liew CW, Assmann A, Dahlgren GM, Peters JL, Shackman JG, Zhang M, Artner I, Satin LS, Stein R, Holzenberger M, Kennedy RT, Kahn CR, Kulkarni RN.

Nat Genet. 2006 May;38(5):583-8. Epub 2006 Apr 23.

PMID:
16642022
13.

The biology of incretin hormones.

Drucker DJ.

Cell Metab. 2006 Mar;3(3):153-65. Review.

14.

Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes.

Gunton JE, Kulkarni RN, Yim S, Okada T, Hawthorne WJ, Tseng YH, Roberson RS, Ricordi C, O'Connell PJ, Gonzalez FJ, Kahn CR.

Cell. 2005 Aug 12;122(3):337-49.

15.

Mechanisms of compensatory beta-cell growth in insulin-resistant rats: roles of Akt kinase.

Jetton TL, Lausier J, LaRock K, Trotman WE, Larmie B, Habibovic A, Peshavaria M, Leahy JL.

Diabetes. 2005 Aug;54(8):2294-304.

16.

Leptin receptor signaling and the regulation of mammalian physiology.

Myers MG Jr.

Recent Prog Horm Res. 2004;59:287-304. Review.

PMID:
14749507
17.

cAMP promotes pancreatic beta-cell survival via CREB-mediated induction of IRS2.

Jhala US, Canettieri G, Screaton RA, Kulkarni RN, Krajewski S, Reed J, Walker J, Lin X, White M, Montminy M.

Genes Dev. 2003 Jul 1;17(13):1575-80.

18.

Role of VEGF-A in vascularization of pancreatic islets.

Lammert E, Gu G, McLaughlin M, Brown D, Brekken R, Murtaugh LC, Gerber HP, Ferrara N, Melton DA.

Curr Biol. 2003 Jun 17;13(12):1070-4.

19.

Activation of the KATP channel-independent signaling pathway by the nonhydrolyzable analog of leucine, BCH.

Liu YJ, Cheng H, Drought H, MacDonald MJ, Sharp GW, Straub SG.

Am J Physiol Endocrinol Metab. 2003 Aug;285(2):E380-9. Epub 2003 Apr 22.

PMID:
12709398
20.

Selective deletion of leptin receptor in neurons leads to obesity.

Cohen P, Zhao C, Cai X, Montez JM, Rohani SC, Feinstein P, Mombaerts P, Friedman JM.

J Clin Invest. 2001 Oct;108(8):1113-21.

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