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Items: 1 to 20 of 43

1.

HIF1alpha synergizes with glucocorticoids to promote BFU-E progenitor self-renewal.

Flygare J, Rayon Estrada V, Shin C, Gupta S, Lodish HF.

Blood. 2011 Mar 24;117(12):3435-44. doi: 10.1182/blood-2010-07-295550. Epub 2010 Dec 21.

2.

Regulation of the HIF-1alpha level is essential for hematopoietic stem cells.

Takubo K, Goda N, Yamada W, Iriuchishima H, Ikeda E, Kubota Y, Shima H, Johnson RS, Hirao A, Suematsu M, Suda T.

Cell Stem Cell. 2010 Sep 3;7(3):391-402. doi: 10.1016/j.stem.2010.06.020.

3.

The distinct metabolic profile of hematopoietic stem cells reflects their location in a hypoxic niche.

Simsek T, Kocabas F, Zheng J, Deberardinis RJ, Mahmoud AI, Olson EN, Schneider JW, Zhang CC, Sadek HA.

Cell Stem Cell. 2010 Sep 3;7(3):380-90. doi: 10.1016/j.stem.2010.07.011.

4.

Osteoblast precursors, but not mature osteoblasts, move into developing and fractured bones along with invading blood vessels.

Maes C, Kobayashi T, Selig MK, Torrekens S, Roth SI, Mackem S, Carmeliet G, Kronenberg HM.

Dev Cell. 2010 Aug 17;19(2):329-44. doi: 10.1016/j.devcel.2010.07.010.

5.

Mesenchymal and haematopoietic stem cells form a unique bone marrow niche.

Méndez-Ferrer S, Michurina TV, Ferraro F, Mazloom AR, Macarthur BD, Lira SA, Scadden DT, Ma'ayan A, Enikolopov GN, Frenette PS.

Nature. 2010 Aug 12;466(7308):829-34. doi: 10.1038/nature09262.

6.

Prolyl hydroxylase domain-containing protein inhibitors as stabilizers of hypoxia-inducible factor: small molecule-based therapeutics for anemia.

Yan L, Colandrea VJ, Hale JJ.

Expert Opin Ther Pat. 2010 Sep;20(9):1219-45. doi: 10.1517/13543776.2010.510836. Review.

PMID:
20698812
7.

Dipeptidyl-quinolone derivatives inhibit hypoxia inducible factor-1α prolyl hydroxylases-1, -2, and -3 with altered selectivity.

Murray JK, Balan C, Allgeier AM, Kasparian A, Viswanadhan V, Wilde C, Allen JR, Yoder SC, Biddlecome G, Hungate RW, Miranda LP.

J Comb Chem. 2010 Sep 13;12(5):676-86. doi: 10.1021/cc100073a.

PMID:
20666436
8.

Reactivation of hepatic EPO synthesis in mice after PHD loss.

Minamishima YA, Kaelin WG Jr.

Science. 2010 Jul 23;329(5990):407. doi: 10.1126/science.1192811.

9.

Hepatic HIF-2 regulates erythropoietic responses to hypoxia in renal anemia.

Kapitsinou PP, Liu Q, Unger TL, Rha J, Davidoff O, Keith B, Epstein JA, Moores SL, Erickson-Miller CL, Haase VH.

Blood. 2010 Oct 21;116(16):3039-48. doi: 10.1182/blood-2010-02-270322. Epub 2010 Jul 13.

10.

Hypoxic regulation of erythropoiesis and iron metabolism.

Haase VH.

Am J Physiol Renal Physiol. 2010 Jul;299(1):F1-13. doi: 10.1152/ajprenal.00174.2010. Epub 2010 May 5. Review.

11.

Increased skeletal VEGF enhances beta-catenin activity and results in excessively ossified bones.

Maes C, Goossens S, Bartunkova S, Drogat B, Coenegrachts L, Stockmans I, Moermans K, Nyabi O, Haigh K, Naessens M, Haenebalcke L, Tuckermann JP, Tjwa M, Carmeliet P, Mandic V, David JP, Behrens A, Nagy A, Carmeliet G, Haigh JJ.

EMBO J. 2010 Jan 20;29(2):424-41. doi: 10.1038/emboj.2009.361. Epub 2009 Dec 10.

12.

The glial cell response is an essential component of hypoxia-induced erythropoiesis in mice.

Weidemann A, Kerdiles YM, Knaup KX, Rafie CA, Boutin AT, Stockmann C, Takeda N, Scadeng M, Shih AY, Haase VH, Simon MC, Kleinfeld D, Johnson RS.

J Clin Invest. 2009 Nov;119(11):3373-83. doi: 10.1172/JCI39378. Epub 2009 Oct 5.

13.

Osteoprotegerin abrogated cortical porosity and bone marrow fibrosis in a mouse model of constitutive activation of the PTH/PTHrP receptor.

Ohishi M, Chiusaroli R, Ominsky M, Asuncion F, Thomas C, Khatri R, Kostenuik P, Schipani E.

Am J Pathol. 2009 Jun;174(6):2160-71. doi: 10.2353/ajpath.2009.081026. Epub 2009 Apr 23.

14.

Osteoblastic regulation of B lymphopoiesis is mediated by Gs{alpha}-dependent signaling pathways.

Wu JY, Purton LE, Rodda SJ, Chen M, Weinstein LS, McMahon AP, Scadden DT, Kronenberg HM.

Proc Natl Acad Sci U S A. 2008 Nov 4;105(44):16976-81. doi: 10.1073/pnas.0802898105. Epub 2008 Oct 28.

15.

Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway.

Kaelin WG Jr, Ratcliffe PJ.

Mol Cell. 2008 May 23;30(4):393-402. doi: 10.1016/j.molcel.2008.04.009. Review.

16.

Elucidation of the phenotypic, functional, and molecular topography of a myeloerythroid progenitor cell hierarchy.

Pronk CJ, Rossi DJ, Månsson R, Attema JL, Norddahl GL, Chan CK, Sigvardsson M, Weissman IL, Bryder D.

Cell Stem Cell. 2007 Oct 11;1(4):428-42. doi: 10.1016/j.stem.2007.07.005.

17.

Hematopoietic stem cell transplant in mice by intra-femoral injection.

Zhan Y, Zhao Y.

Methods Mol Biol. 2008;430:161-9. doi: 10.1007/978-1-59745-182-6_11.

PMID:
18370298
18.

The VHL tumor suppressor and HIF: insights from genetic studies in mice.

Kapitsinou PP, Haase VH.

Cell Death Differ. 2008 Apr;15(4):650-9. doi: 10.1038/sj.cdd.4402313. Epub 2008 Jan 25. Review.

19.

Repression via the GATA box is essential for tissue-specific erythropoietin gene expression.

Obara N, Suzuki N, Kim K, Nagasawa T, Imagawa S, Yamamoto M.

Blood. 2008 May 15;111(10):5223-32. doi: 10.1182/blood-2007-10-115857. Epub 2008 Jan 17.

20.

Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins.

Takeda K, Aguila HL, Parikh NS, Li X, Lamothe K, Duan LJ, Takeda H, Lee FS, Fong GH.

Blood. 2008 Mar 15;111(6):3229-35. Epub 2007 Dec 4.

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