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Items: 11

1.

Interactions of tyrosine kinase inhibitors with organic cation transporters and multidrug and toxic compound extrusion proteins.

Minematsu T, Giacomini KM.

Mol Cancer Ther. 2011 Mar;10(3):531-9. doi: 10.1158/1535-7163.MCT-10-0731. Epub 2011 Jan 20.

2.

Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes.

GoDARTS and UKPDS Diabetes Pharmacogenetics Study Group; Wellcome Trust Case Control Consortium 2, Zhou K, Bellenguez C, Spencer CC, Bennett AJ, Coleman RL, Tavendale R, Hawley SA, Donnelly LA, Schofield C, Groves CJ, Burch L, Carr F, Strange A, Freeman C, Blackwell JM, Bramon E, Brown MA, Casas JP, Corvin A, Craddock N, Deloukas P, Dronov S, Duncanson A, Edkins S, Gray E, Hunt S, Jankowski J, Langford C, Markus HS, Mathew CG, Plomin R, Rautanen A, Sawcer SJ, Samani NJ, Trembath R, Viswanathan AC, Wood NW; MAGIC investigators, Harries LW, Hattersley AT, Doney AS, Colhoun H, Morris AD, Sutherland C, Hardie DG, Peltonen L, McCarthy MI, Holman RR, Palmer CN, Donnelly P, Pearson ER.

Nat Genet. 2011 Feb;43(2):117-20. doi: 10.1038/ng.735. Epub 2010 Dec 26.

3.

Role of organic cation transporter 3 (SLC22A3) and its missense variants in the pharmacologic action of metformin.

Chen L, Pawlikowski B, Schlessinger A, More SS, Stryke D, Johns SJ, Portman MA, Chen E, Ferrin TE, Sali A, Giacomini KM.

Pharmacogenet Genomics. 2010 Nov;20(11):687-99. doi: 10.1097/FPC.0b013e32833fe789.

4.

Ionizing radiation activates AMP-activated kinase (AMPK): a target for radiosensitization of human cancer cells.

Sanli T, Rashid A, Liu C, Harding S, Bristow RG, Cutz JC, Singh G, Wright J, Tsakiridis T.

Int J Radiat Oncol Biol Phys. 2010 Sep 1;78(1):221-9. doi: 10.1016/j.ijrobp.2010.03.005. Epub 2010 Jul 7.

PMID:
20615625
5.

Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state.

Foretz M, H├ębrard S, Leclerc J, Zarrinpashneh E, Soty M, Mithieux G, Sakamoto K, Andreelli F, Viollet B.

J Clin Invest. 2010 Jul;120(7):2355-69. doi: 10.1172/JCI40671. Epub 2010 Jun 23.

6.

Genotype-dependent effects of inhibitors of the organic cation transporter, OCT1: predictions of metformin interactions.

Ahlin G, Chen L, Lazorova L, Chen Y, Ianculescu AG, Davis RL, Giacomini KM, Artursson P.

Pharmacogenomics J. 2011 Dec;11(6):400-11. doi: 10.1038/tpj.2010.54. Epub 2010 Jun 22.

PMID:
20567254
7.

Etoposide induces ATM-dependent mitochondrial biogenesis through AMPK activation.

Fu X, Wan S, Lyu YL, Liu LF, Qi H.

PLoS One. 2008 Apr 23;3(4):e2009. doi: 10.1371/journal.pone.0002009.

8.

AICAR induces phosphorylation of AMPK in an ATM-dependent, LKB1-independent manner.

Sun Y, Connors KE, Yang DQ.

Mol Cell Biochem. 2007 Dec;306(1-2):239-45. Epub 2007 Sep 5.

PMID:
17786544
9.

Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action.

Shu Y, Sheardown SA, Brown C, Owen RP, Zhang S, Castro RA, Ianculescu AG, Yue L, Lo JC, Burchard EG, Brett CM, Giacomini KM.

J Clin Invest. 2007 May;117(5):1422-31.

10.

Role of AMP-activated protein kinase in mechanism of metformin action.

Zhou G, Myers R, Li Y, Chen Y, Shen X, Fenyk-Melody J, Wu M, Ventre J, Doebber T, Fujii N, Musi N, Hirshman MF, Goodyear LJ, Moller DE.

J Clin Invest. 2001 Oct;108(8):1167-74.

11.

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53.

Canman CE, Lim DS, Cimprich KA, Taya Y, Tamai K, Sakaguchi K, Appella E, Kastan MB, Siliciano JD.

Science. 1998 Sep 11;281(5383):1677-9.

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