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Neurotoxicity of amyloid β-protein: synaptic and network dysfunction.

Mucke L, Selkoe DJ.

Cold Spring Harb Perspect Med. 2012 Jul;2(7):a006338. doi: 10.1101/cshperspect.a006338. Review.


Proteolytic degradation of amyloid β-protein.

Saido T, Leissring MA.

Cold Spring Harb Perspect Med. 2012 Jun;2(6):a006379. doi: 10.1101/cshperspect.a006379. Review.


Trafficking and proteolytic processing of APP.

Haass C, Kaether C, Thinakaran G, Sisodia S.

Cold Spring Harb Perspect Med. 2012 May;2(5):a006270. doi: 10.1101/cshperspect.a006270. Review.


Human apoE isoforms differentially regulate brain amyloid-β peptide clearance.

Castellano JM, Kim J, Stewart FR, Jiang H, DeMattos RB, Patterson BW, Fagan AM, Morris JC, Mawuenyega KG, Cruchaga C, Goate AM, Bales KR, Paul SM, Bateman RJ, Holtzman DM.

Sci Transl Med. 2011 Jun 29;3(89):89ra57. doi: 10.1126/scitranslmed.3002156.


Tau-induced defects in synaptic plasticity, learning, and memory are reversible in transgenic mice after switching off the toxic Tau mutant.

Sydow A, Van der Jeugd A, Zheng F, Ahmed T, Balschun D, Petrova O, Drexler D, Zhou L, Rune G, Mandelkow E, D'Hooge R, Alzheimer C, Mandelkow EM.

J Neurosci. 2011 Feb 16;31(7):2511-25. doi: 10.1523/JNEUROSCI.5245-10.2011.


Amyloid-β/Fyn-induced synaptic, network, and cognitive impairments depend on tau levels in multiple mouse models of Alzheimer's disease.

Roberson ED, Halabisky B, Yoo JW, Yao J, Chin J, Yan F, Wu T, Hamto P, Devidze N, Yu GQ, Palop JJ, Noebels JL, Mucke L.

J Neurosci. 2011 Jan 12;31(2):700-11. doi: 10.1523/JNEUROSCI.4152-10.2011.


Tau mislocalization to dendritic spines mediates synaptic dysfunction independently of neurodegeneration.

Hoover BR, Reed MN, Su J, Penrod RD, Kotilinek LA, Grant MK, Pitstick R, Carlson GA, Lanier LM, Yuan LL, Ashe KH, Liao D.

Neuron. 2010 Dec 22;68(6):1067-81. doi: 10.1016/j.neuron.2010.11.030.


Lipoprotein receptors--an evolutionarily ancient multifunctional receptor family.

Dieckmann M, Dietrich MF, Herz J.

Biol Chem. 2010 Nov;391(11):1341-63. doi: 10.1515/BC.2010.129. Review.


Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models.

Ittner LM, Ke YD, Delerue F, Bi M, Gladbach A, van Eersel J, Wölfing H, Chieng BC, Christie MJ, Napier IA, Eckert A, Staufenbiel M, Hardeman E, Götz J.

Cell. 2010 Aug 6;142(3):387-97. doi: 10.1016/j.cell.2010.06.036. Epub 2010 Jul 22.


Mutation of megalin leads to urinary loss of selenoprotein P and selenium deficiency in serum, liver, kidneys and brain.

Chiu-Ugalde J, Theilig F, Behrends T, Drebes J, Sieland C, Subbarayal P, Köhrle J, Hammes A, Schomburg L, Schweizer U.

Biochem J. 2010 Oct 1;431(1):103-11. doi: 10.1042/BJ20100779.


Reduced Reelin expression accelerates amyloid-beta plaque formation and tau pathology in transgenic Alzheimer's disease mice.

Kocherhans S, Madhusudan A, Doehner J, Breu KS, Nitsch RM, Fritschy JM, Knuesel I.

J Neurosci. 2010 Jul 7;30(27):9228-40. doi: 10.1523/JNEUROSCI.0418-10.2010.


Role for Reelin in stabilizing cortical architecture.

Frotscher M.

Trends Neurosci. 2010 Sep;33(9):407-14. doi: 10.1016/j.tins.2010.06.001. Epub 2010 Jul 1. Review.


Amyloid-beta-induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks.

Palop JJ, Mucke L.

Nat Neurosci. 2010 Jul;13(7):812-8. doi: 10.1038/nn.2583. Review.


ApoE4 reduces glutamate receptor function and synaptic plasticity by selectively impairing ApoE receptor recycling.

Chen Y, Durakoglugil MS, Xian X, Herz J.

Proc Natl Acad Sci U S A. 2010 Jun 29;107(26):12011-6. doi: 10.1073/pnas.0914984107. Epub 2010 Jun 14.


Deleterious effects of amyloid beta oligomers acting as an extracellular scaffold for mGluR5.

Renner M, Lacor PN, Velasco PT, Xu J, Contractor A, Klein WL, Triller A.

Neuron. 2010 Jun 10;66(5):739-54. doi: 10.1016/j.neuron.2010.04.029.


Emerging topics in Reelin function.

Förster E, Bock HH, Herz J, Chai X, Frotscher M, Zhao S.

Eur J Neurosci. 2010 May;31(9):1511-8. doi: 10.1111/j.1460-9568.2010.07222.x. Review.


LRP2 in ependymal cells regulates BMP signaling in the adult neurogenic niche.

Gajera CR, Emich H, Lioubinski O, Christ A, Beckervordersandforth-Bonk R, Yoshikawa K, Bachmann S, Christensen EI, Götz M, Kempermann G, Peterson AS, Willnow TE, Hammes A.

J Cell Sci. 2010 Jun 1;123(Pt 11):1922-30. doi: 10.1242/jcs.065912. Epub 2010 May 11.


Lrp4 regulates initiation of ureteric budding and is crucial for kidney formation--a mouse model for Cenani-Lenz syndrome.

Karner CM, Dietrich MF, Johnson EB, Kappesser N, Tennert C, Percin F, Wollnik B, Carroll TJ, Herz J.

PLoS One. 2010 Apr 29;5(4):e10418. doi: 10.1371/journal.pone.0010418.


Memory impairment in transgenic Alzheimer mice requires cellular prion protein.

Gimbel DA, Nygaard HB, Coffey EE, Gunther EC, Laurén J, Gimbel ZA, Strittmatter SM.

J Neurosci. 2010 May 5;30(18):6367-74. doi: 10.1523/JNEUROSCI.0395-10.2010.


Learning, AMPA receptor mobility and synaptic plasticity depend on n-cofilin-mediated actin dynamics.

Rust MB, Gurniak CB, Renner M, Vara H, Morando L, Görlich A, Sassoè-Pognetto M, Banchaabouchi MA, Giustetto M, Triller A, Choquet D, Witke W.

EMBO J. 2010 Jun 2;29(11):1889-902. doi: 10.1038/emboj.2010.72. Epub 2010 Apr 20.

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