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Interleukin-1 receptor-associated kinase-3 is a key inhibitor of inflammation in obesity and metabolic syndrome.

Hulsmans M, Geeraert B, De Keyzer D, Mertens A, Lannoo M, Vanaudenaerde B, Hoylaerts M, Benhabilès N, Tsatsanis C, Mathieu C, Holvoet P.

PLoS One. 2012;7(1):e30414. doi: 10.1371/journal.pone.0030414.


Decreased IRS2 and TIMP3 expression in monocytes from offspring of type 2 diabetic patients is correlated with insulin resistance and increased intima-media thickness.

Cardellini M, Menghini R, Luzi A, Davato F, Cardolini I, D'Alfonso R, Gentileschi P, Rizza S, Marini MA, Porzio O, Lauro D, Sbraccia P, Lauro R, Federici M.

Diabetes. 2011 Dec;60(12):3265-70. doi: 10.2337/db11-0162.


MicroRNAs regulating oxidative stress and inflammation in relation to obesity and atherosclerosis.

Hulsmans M, De Keyzer D, Holvoet P.

FASEB J. 2011 Aug;25(8):2515-27. doi: 10.1096/fj.11-181149. Review.


Adiponectin enhances insulin sensitivity by increasing hepatic IRS-2 expression via a macrophage-derived IL-6-dependent pathway.

Awazawa M, Ueki K, Inabe K, Yamauchi T, Kubota N, Kaneko K, Kobayashi M, Iwane A, Sasako T, Okazaki Y, Ohsugi M, Takamoto I, Yamashita S, Asahara H, Akira S, Kasuga M, Kadowaki T.

Cell Metab. 2011 Apr 6;13(4):401-12. doi: 10.1016/j.cmet.2011.02.010.


MicroRNAs: the fine-tuners of Toll-like receptor signalling.

O'Neill LA, Sheedy FJ, McCoy CE.

Nat Rev Immunol. 2011 Mar;11(3):163-75. doi: 10.1038/nri2957. Review.


MicroRNAs in resolution of acute inflammation: identification of novel resolvin D1-miRNA circuits.

Recchiuti A, Krishnamoorthy S, Fredman G, Chiang N, Serhan CN.

FASEB J. 2011 Feb;25(2):544-60. doi: 10.1096/fj.10-169599.


Vascular microRNAs.

Bonauer A, Boon RA, Dimmeler S.

Curr Drug Targets. 2010 Aug;11(8):943-9. Review.


MicroRNAs in atherosclerosis and lipoprotein metabolism.

Vickers KC, Remaley AT.

Curr Opin Endocrinol Diabetes Obes. 2010 Apr;17(2):150-5. doi: 10.1097/MED.0b013e32833727a1. Review.


The impact of macrophage insulin resistance on advanced atherosclerotic plaque progression.

Tabas I, Tall A, Accili D.

Circ Res. 2010 Jan 8;106(1):58-67. doi: 10.1161/CIRCRESAHA.109.208488. Review.


The vicious circle between oxidative stress and inflammation in atherosclerosis.

Hulsmans M, Holvoet P.

J Cell Mol Med. 2010 Jan;14(1-2):70-8. doi: 10.1111/j.1582-4934.2009.00978.x. Review.


Epigenetics: a molecular link between environmental factors and type 2 diabetes.

Ling C, Groop L.

Diabetes. 2009 Dec;58(12):2718-25. doi: 10.2337/db09-1003. Review. No abstract available.


miR-146a is critical for endotoxin-induced tolerance: IMPLICATION IN INNATE IMMUNITY.

Nahid MA, Pauley KM, Satoh M, Chan EK.

J Biol Chem. 2009 Dec 11;284(50):34590-9. doi: 10.1074/jbc.M109.056317.


Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity.

Alberti KG, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA, Fruchart JC, James WP, Loria CM, Smith SC Jr; International Diabetes Federation Task Force on Epidemiology and Prevention.; Hational Heart, Lung, and Blood Institute.; American Heart Association.; World Heart Federation.; International Atherosclerosis Society.; International Association for the Study of Obesity..

Circulation. 2009 Oct 20;120(16):1640-5. doi: 10.1161/CIRCULATIONAHA.109.192644.


MicroRNAs induced during adipogenesis that accelerate fat cell development are downregulated in obesity.

Xie H, Lim B, Lodish HF.

Diabetes. 2009 May;58(5):1050-7. doi: 10.2337/db08-1299.


Overexpression of adiponectin receptors potentiates the antiinflammatory action of subeffective dose of globular adiponectin in vascular endothelial cells.

Zhang P, Wang Y, Fan Y, Tang Z, Wang N.

Arterioscler Thromb Vasc Biol. 2009 Jan;29(1):67-74. doi: 10.1161/ATVBAHA.108.178061.


Association between circulating oxidized low-density lipoprotein and incidence of the metabolic syndrome.

Holvoet P, Lee DH, Steffes M, Gross M, Jacobs DR Jr.

JAMA. 2008 May 21;299(19):2287-93. doi: 10.1001/jama.299.19.2287.


Adiponectin decreases C-reactive protein synthesis and secretion from endothelial cells: evidence for an adipose tissue-vascular loop.

Devaraj S, Torok N, Dasu MR, Samols D, Jialal I.

Arterioscler Thromb Vasc Biol. 2008 Jul;28(7):1368-74. doi: 10.1161/ATVBAHA.108.163303.


Role of mitochondrial dysfunction in insulin resistance.

Kim JA, Wei Y, Sowers JR.

Circ Res. 2008 Feb 29;102(4):401-14. doi: 10.1161/CIRCRESAHA.107.165472. Review.


Prognostic value of adiponectin for cardiovascular disease and mortality.

Dekker JM, Funahashi T, Nijpels G, Pilz S, Stehouwer CD, Snijder MB, Bouter LM, Matsuzawa Y, Shimomura I, Heine RJ.

J Clin Endocrinol Metab. 2008 Apr;93(4):1489-96. doi: 10.1210/jc.2007-1436.


Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?

Filipowicz W, Bhattacharyya SN, Sonenberg N.

Nat Rev Genet. 2008 Feb;9(2):102-14. doi: 10.1038/nrg2290. Review.


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