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Soluble growth factors stimulate spermatogonial stem cell divisions that maintain a stem cell pool and produce progenitors in vitro.

Ebata KT, Yeh JR, Zhang X, Nagano MC.

Exp Cell Res. 2011 Jun 10;317(10):1319-29. doi: 10.1016/j.yexcr.2011.03.013. Epub 2011 Mar 21.


Mouse germ line stem cells undergo rapid and stochastic turnover.

Klein AM, Nakagawa T, Ichikawa R, Yoshida S, Simons BD.

Cell Stem Cell. 2010 Aug 6;7(2):214-24. doi: 10.1016/j.stem.2010.05.017.


Missing heritability: paternal age effect mutations and selfish spermatogonia.

Goriely A, Wilkie AO.

Nat Rev Genet. 2010 Aug;11(8):589. doi: 10.1038/nrg2809-c1. No abstract available.


Cell signaling by receptor tyrosine kinases.

Lemmon MA, Schlessinger J.

Cell. 2010 Jun 25;141(7):1117-34. doi: 10.1016/j.cell.2010.06.011. Review.


Differential phosphoproteomics of fibroblast growth factor signaling: identification of Src family kinase-mediated phosphorylation events.

Cunningham DL, Sweet SM, Cooper HJ, Heath JK.

J Proteome Res. 2010 May 7;9(5):2317-28. doi: 10.1021/pr9010475.


RET gene mutations are not involved in the origin of human testicular seminoma.

Chevalier N, Barlier A, Roche C, Mograbi B, Camparo P, Devouassoux-Shisheboran M, Michiels JF, Nebout M, Chevallier D, Benahmed M, Enjalbert A, Fénichel P.

Int J Androl. 2010 Dec;33(6):848-52. doi: 10.1111/j.1365-2605.2009.01043.x.


Update multiple endocrine neoplasia type 2.

Raue F, Frank-Raue K.

Fam Cancer. 2010 Sep;9(3):449-57. doi: 10.1007/s10689-010-9320-2. Review.


Rate, molecular spectrum, and consequences of human mutation.

Lynch M.

Proc Natl Acad Sci U S A. 2010 Jan 19;107(3):961-8. doi: 10.1073/pnas.0912629107. Epub 2010 Jan 4.


Targeting the RET pathway in thyroid cancer.

Wells SA Jr, Santoro M.

Clin Cancer Res. 2009 Dec 1;15(23):7119-23. doi: 10.1158/1078-0432.CCR-08-2742. Epub 2009 Nov 24. Review.


Activating mutations in FGFR3 and HRAS reveal a shared genetic origin for congenital disorders and testicular tumors.

Goriely A, Hansen RM, Taylor IB, Olesen IA, Jacobsen GK, McGowan SJ, Pfeifer SP, McVean GA, Rajpert-De Meyts E, Wilkie AO.

Nat Genet. 2009 Nov;41(11):1247-52. doi: 10.1038/ng.470. Epub 2009 Oct 25.


The ups and downs of mutation frequencies during aging can account for the Apert syndrome paternal age effect.

Yoon SR, Qin J, Glaser RL, Jabs EW, Wexler NS, Sokol R, Arnheim N, Calabrese P.

PLoS Genet. 2009 Jul;5(7):e1000558. doi: 10.1371/journal.pgen.1000558. Epub 2009 Jul 10.


Genetic reconstruction of mouse spermatogonial stem cell self-renewal in vitro by Ras-cyclin D2 activation.

Lee J, Kanatsu-Shinohara M, Morimoto H, Kazuki Y, Takashima S, Oshimura M, Toyokuni S, Shinohara T.

Cell Stem Cell. 2009 Jul 2;5(1):76-86. doi: 10.1016/j.stem.2009.04.020.


Understanding what determines the frequency and pattern of human germline mutations.

Arnheim N, Calabrese P.

Nat Rev Genet. 2009 Jul;10(7):478-88. doi: 10.1038/nrg2529. Review.


Medullary thyroid cancer: management guidelines of the American Thyroid Association.

American Thyroid Association Guidelines Task Force, Kloos RT, Eng C, Evans DB, Francis GL, Gagel RF, Gharib H, Moley JF, Pacini F, Ringel MD, Schlumberger M, Wells SA Jr.

Thyroid. 2009 Jun;19(6):565-612. doi: 10.1089/thy.2008.0403. Review. Erratum in: Thyroid. 2009 Nov;19(11):1295.


The precise sequence of FGF receptor autophosphorylation is kinetically driven and is disrupted by oncogenic mutations.

Lew ED, Furdui CM, Anderson KS, Schlessinger J.

Sci Signal. 2009 Feb 17;2(58):ra6. doi: 10.1126/scisignal.2000021.


A germ-line-selective advantage rather than an increased mutation rate can explain some unexpectedly common human disease mutations.

Choi SK, Yoon SR, Calabrese P, Arnheim N.

Proc Natl Acad Sci U S A. 2008 Jul 22;105(29):10143-8. doi: 10.1073/pnas.0801267105. Epub 2008 Jul 16.


Regulation of spermatogonial stem cell self-renewal in mammals.

Oatley JM, Brinster RL.

Annu Rev Cell Dev Biol. 2008;24:263-86. doi: 10.1146/annurev.cellbio.24.110707.175355. Review.


Regulation of growth factor signaling by FRS2 family docking/scaffold adaptor proteins.

Gotoh N.

Cancer Sci. 2008 Jul;99(7):1319-25. doi: 10.1111/j.1349-7006.2008.00840.x. Epub 2008 Apr 29. Review.


Extracellular point mutations in FGFR2 elicit unexpected changes in intracellular signalling.

Ahmed Z, Schüller AC, Suhling K, Tregidgo C, Ladbury JE.

Biochem J. 2008 Jul 1;413(1):37-49. doi: 10.1042/BJ20071594.


GDNF-mediated signaling via RET tyrosine 1062 is essential for maintenance of spermatogonial stem cells.

Jijiwa M, Kawai K, Fukihara J, Nakamura A, Hasegawa M, Suzuki C, Sato T, Enomoto A, Asai N, Murakumo Y, Takahashi M.

Genes Cells. 2008 Apr;13(4):365-74. doi: 10.1111/j.1365-2443.2008.01171.x.

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