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Items: 1 to 20 of 39

1.

Inhibition of DNA-dependent protein kinase induces accelerated senescence in irradiated human cancer cells.

Azad A, Jackson S, Cullinane C, Natoli A, Neilsen PM, Callen DF, Maira SM, Hackl W, McArthur GA, Solomon B.

Mol Cancer Res. 2011 Dec;9(12):1696-707. doi: 10.1158/1541-7786.MCR-11-0312. Epub 2011 Oct 18.

2.

A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations.

Toledo LI, Murga M, Zur R, Soria R, Rodriguez A, Martinez S, Oyarzabal J, Pastor J, Bischoff JR, Fernandez-Capetillo O.

Nat Struct Mol Biol. 2011 Jun;18(6):721-7. doi: 10.1038/nsmb.2076. Epub 2011 May 8.

3.

Strategies to improve radiotherapy with targeted drugs.

Begg AC, Stewart FA, Vens C.

Nat Rev Cancer. 2011 Apr;11(4):239-53. doi: 10.1038/nrc3007. Review.

PMID:
21430696
4.

The influence of heterochromatin on DNA double strand break repair: Getting the strong, silent type to relax.

Goodarzi AA, Jeggo P, Lobrich M.

DNA Repair (Amst). 2010 Dec 10;9(12):1273-82. doi: 10.1016/j.dnarep.2010.09.013. Epub 2010 Oct 30. Review.

PMID:
21036673
5.

Activity of the novel dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 against T-cell acute lymphoblastic leukemia.

Chiarini F, Grimaldi C, Ricci F, Tazzari PL, Evangelisti C, Ognibene A, Battistelli M, Falcieri E, Melchionda F, Pession A, Pagliaro P, McCubrey JA, Martelli AM.

Cancer Res. 2010 Oct 15;70(20):8097-107. doi: 10.1158/0008-5472.CAN-10-1814. Epub 2010 Sep 28.

6.

Targeting nonhomologous end-joining through epidermal growth factor receptor inhibition: rationale and strategies for radiosensitization.

Mukherjee B, Choy H, Nirodi C, Burma S.

Semin Radiat Oncol. 2010 Oct;20(4):250-7. doi: 10.1016/j.semradonc.2010.05.002. Review.

7.

PTEN loss compromises homologous recombination repair in astrocytes: implications for glioblastoma therapy with temozolomide or poly(ADP-ribose) polymerase inhibitors.

McEllin B, Camacho CV, Mukherjee B, Hahm B, Tomimatsu N, Bachoo RM, Burma S.

Cancer Res. 2010 Jul 1;70(13):5457-64. doi: 10.1158/0008-5472.CAN-09-4295. Epub 2010 Jun 8.

8.

MOF and histone H4 acetylation at lysine 16 are critical for DNA damage response and double-strand break repair.

Sharma GG, So S, Gupta A, Kumar R, Cayrou C, Avvakumov N, Bhadra U, Pandita RK, Porteus MH, Chen DJ, Cote J, Pandita TK.

Mol Cell Biol. 2010 Jul;30(14):3582-95. doi: 10.1128/MCB.01476-09. Epub 2010 May 17.

9.

Phosphorylation of Exo1 modulates homologous recombination repair of DNA double-strand breaks.

Bolderson E, Tomimatsu N, Richard DJ, Boucher D, Kumar R, Pandita TK, Burma S, Khanna KK.

Nucleic Acids Res. 2010 Apr;38(6):1821-31. doi: 10.1093/nar/gkp1164. Epub 2009 Dec 17.

10.

Specific apoptosis induction by the dual PI3K/mTor inhibitor NVP-BEZ235 in HER2 amplified and PIK3CA mutant breast cancer cells.

Brachmann SM, Hofmann I, Schnell C, Fritsch C, Wee S, Lane H, Wang S, Garcia-Echeverria C, Maira SM.

Proc Natl Acad Sci U S A. 2009 Dec 29;106(52):22299-304. doi: 10.1073/pnas.0905152106. Epub 2009 Dec 10.

11.

Dual phosphoinositide 3-kinase/mammalian target of rapamycin blockade is an effective radiosensitizing strategy for the treatment of non-small cell lung cancer harboring K-RAS mutations.

Konstantinidou G, Bey EA, Rabellino A, Schuster K, Maira MS, Gazdar AF, Amici A, Boothman DA, Scaglioni PP.

Cancer Res. 2009 Oct 1;69(19):7644-52. doi: 10.1158/0008-5472.CAN-09-0823. Epub 2009 Sep 29.

12.

ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2.

Beucher A, Birraux J, Tchouandong L, Barton O, Shibata A, Conrad S, Goodarzi AA, Krempler A, Jeggo PA, Löbrich M.

EMBO J. 2009 Nov 4;28(21):3413-27. doi: 10.1038/emboj.2009.276. Epub 2009 Sep 24.

13.

NVP-BEZ235, a novel dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor, elicits multifaceted antitumor activities in human gliomas.

Liu TJ, Koul D, LaFortune T, Tiao N, Shen RJ, Maira SM, Garcia-Echevrria C, Yung WK.

Mol Cancer Ther. 2009 Aug;8(8):2204-10. doi: 10.1158/1535-7163.MCT-09-0160. Epub 2009 Aug 11.

14.

Targeting the phosphoinositide 3-kinase pathway in cancer.

Liu P, Cheng H, Roberts TM, Zhao JJ.

Nat Rev Drug Discov. 2009 Aug;8(8):627-44. doi: 10.1038/nrd2926. Review.

15.

Distinct roles of ATR and DNA-PKcs in triggering DNA damage responses in ATM-deficient cells.

Tomimatsu N, Mukherjee B, Burma S.

EMBO Rep. 2009 Jun;10(6):629-35. doi: 10.1038/embor.2009.60. Epub 2009 May 15.

16.

EGFRvIII and DNA double-strand break repair: a molecular mechanism for radioresistance in glioblastoma.

Mukherjee B, McEllin B, Camacho CV, Tomimatsu N, Sirasanagandala S, Nannepaga S, Hatanpaa KJ, Mickey B, Madden C, Maher E, Boothman DA, Furnari F, Cavenee WK, Bachoo RM, Burma S.

Cancer Res. 2009 May 15;69(10):4252-9. doi: 10.1158/0008-5472.CAN-08-4853. Epub 2009 May 12.

17.

Pro-survival AKT and ERK signaling from EGFR and mutant EGFRvIII enhances DNA double-strand break repair in human glioma cells.

Golding SE, Morgan RN, Adams BR, Hawkins AJ, Povirk LF, Valerie K.

Cancer Biol Ther. 2009 Apr;8(8):730-8. Epub 2009 Apr 22.

18.
19.

Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers.

Engelman JA, Chen L, Tan X, Crosby K, Guimaraes AR, Upadhyay R, Maira M, McNamara K, Perera SA, Song Y, Chirieac LR, Kaur R, Lightbown A, Simendinger J, Li T, Padera RF, García-Echeverría C, Weissleder R, Mahmood U, Cantley LC, Wong KK.

Nat Med. 2008 Dec;14(12):1351-6. doi: 10.1038/nm.1890. Epub 2008 Nov 30.

20.

Phosphatidylinositol 3-kinase hyperactivation results in lapatinib resistance that is reversed by the mTOR/phosphatidylinositol 3-kinase inhibitor NVP-BEZ235.

Eichhorn PJ, Gili M, Scaltriti M, Serra V, Guzman M, Nijkamp W, Beijersbergen RL, Valero V, Seoane J, Bernards R, Baselga J.

Cancer Res. 2008 Nov 15;68(22):9221-30. doi: 10.1158/0008-5472.CAN-08-1740.

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