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Endoplasmic reticulum-tethered transcription factor cAMP responsive element-binding protein, hepatocyte specific, regulates hepatic lipogenesis, fatty acid oxidation, and lipolysis upon metabolic stress in mice.

Zhang C, Wang G, Zheng Z, Maddipati KR, Zhang X, Dyson G, Williams P, Duncan SA, Kaufman RJ, Zhang K.

Hepatology. 2012 Apr;55(4):1070-82. doi: 10.1002/hep.24783. Epub 2012 Feb 9.


The unfolded protein response transducer IRE1α prevents ER stress-induced hepatic steatosis.

Zhang K, Wang S, Malhotra J, Hassler JR, Back SH, Wang G, Chang L, Xu W, Miao H, Leonardi R, Chen YE, Jackowski S, Kaufman RJ.

EMBO J. 2011 Apr 6;30(7):1357-75. doi: 10.1038/emboj.2011.52. Epub 2011 Mar 15.


Diabetes as a disease of endoplasmic reticulum stress.

Thomas SE, Dalton LE, Daly ML, Malzer E, Marciniak SJ.

Diabetes Metab Res Rev. 2010 Nov;26(8):611-21. doi: 10.1002/dmrr.1132. Epub 2010 Oct 3. Review.


An increase in liver PPARγ2 is an initial event to induce fatty liver in response to a diet high in butter: PPARγ2 knockdown improves fatty liver induced by high-saturated fat.

Yamazaki T, Shiraishi S, Kishimoto K, Miura S, Ezaki O.

J Nutr Biochem. 2011 Jun;22(6):543-53. doi: 10.1016/j.jnutbio.2010.04.009. Epub 2010 Aug 30.


Induction of liver steatosis and lipid droplet formation in ATF6alpha-knockout mice burdened with pharmacological endoplasmic reticulum stress.

Yamamoto K, Takahara K, Oyadomari S, Okada T, Sato T, Harada A, Mori K.

Mol Biol Cell. 2010 Sep 1;21(17):2975-86. doi: 10.1091/mbc.E09-02-0133. Epub 2010 Jul 14.


Airborne particulate matter selectively activates endoplasmic reticulum stress response in the lung and liver tissues.

Laing S, Wang G, Briazova T, Zhang C, Wang A, Zheng Z, Gow A, Chen AF, Rajagopalan S, Chen LC, Sun Q, Zhang K.

Am J Physiol Cell Physiol. 2010 Oct;299(4):C736-49. doi: 10.1152/ajpcell.00529.2009. Epub 2010 Jun 16.


Regulation of hepatic gluconeogenesis by an ER-bound transcription factor, CREBH.

Lee MW, Chanda D, Yang J, Oh H, Kim SS, Yoon YS, Hong S, Park KG, Lee IK, Choi CS, Hanson RW, Choi HS, Koo SH.

Cell Metab. 2010 Apr 7;11(4):331-9. doi: 10.1016/j.cmet.2010.02.016.


The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocation.

Park SW, Zhou Y, Lee J, Lu A, Sun C, Chung J, Ueki K, Ozcan U.

Nat Med. 2010 Apr;16(4):429-37. doi: 10.1038/nm.2099. Epub 2010 Mar 28.


UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators.

Rutkowski DT, Wu J, Back SH, Callaghan MU, Ferris SP, Iqbal J, Clark R, Miao H, Hassler JR, Fornek J, Katze MG, Hussain MM, Song B, Swathirajan J, Wang J, Yau GD, Kaufman RJ.

Dev Cell. 2008 Dec;15(6):829-40. doi: 10.1016/j.devcel.2008.10.015.


Recent insights into hepatic lipid metabolism in non-alcoholic fatty liver disease (NAFLD).

Musso G, Gambino R, Cassader M.

Prog Lipid Res. 2009 Jan;48(1):1-26. doi: 10.1016/j.plipres.2008.08.001. Epub 2008 Sep 9. Review.


From endoplasmic-reticulum stress to the inflammatory response.

Zhang K, Kaufman RJ.

Nature. 2008 Jul 24;454(7203):455-62. doi: 10.1038/nature07203. Review.


Regulation of hepatic lipogenesis by the transcription factor XBP1.

Lee AH, Scapa EF, Cohen DE, Glimcher LH.

Science. 2008 Jun 13;320(5882):1492-6. doi: 10.1126/science.1158042.


Dephosphorylation of translation initiation factor 2alpha enhances glucose tolerance and attenuates hepatosteatosis in mice.

Oyadomari S, Harding HP, Zhang Y, Oyadomari M, Ron D.

Cell Metab. 2008 Jun;7(6):520-32. doi: 10.1016/j.cmet.2008.04.011.


Endoplasmic reticulum stress, hepatocyte CD1d and NKT cell abnormalities in murine fatty livers.

Yang L, Jhaveri R, Huang J, Qi Y, Diehl AM.

Lab Invest. 2007 Sep;87(9):927-37. Epub 2007 Jul 2.


Signal integration in the endoplasmic reticulum unfolded protein response.

Ron D, Walter P.

Nat Rev Mol Cell Biol. 2007 Jul;8(7):519-29. Review.


Bortezomib: proteasome inhibition as an effective anticancer therapy.

Richardson PG, Mitsiades C, Hideshima T, Anderson KC.

Annu Rev Med. 2006;57:33-47. Review.


Bortezomib inhibits PKR-like endoplasmic reticulum (ER) kinase and induces apoptosis via ER stress in human pancreatic cancer cells.

Nawrocki ST, Carew JS, Dunner K Jr, Boise LH, Chiao PJ, Huang P, Abbruzzese JL, McConkey DJ.

Cancer Res. 2005 Dec 15;65(24):11510-9.


PPARgamma2 regulates lipogenesis and lipid accumulation in steatotic hepatocytes.

Schadinger SE, Bucher NL, Schreiber BM, Farmer SR.

Am J Physiol Endocrinol Metab. 2005 Jun;288(6):E1195-205. Epub 2005 Jan 11.

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