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Hepatitis B virus core particles displaying Mycobacterium tuberculosis antigen ESAT-6 enhance ESAT-6-specific immune responses.

Yin Y, Li H, Wu S, Dong D, Zhang J, Fu L, Xu J, Chen W.

Vaccine. 2011 Aug 5;29(34):5645-51. doi: 10.1016/j.vaccine.2011.06.012. Epub 2011 Jun 29.



Lawn SD, Zumla AI.

Lancet. 2011 Jul 2;378(9785):57-72. doi: 10.1016/S0140-6736(10)62173-3. Epub 2011 Mar 21. Review.


Critical coordination of innate immune defense against Toxoplasma gondii by dendritic cells responding via their Toll-like receptors.

Hou B, Benson A, Kuzmich L, DeFranco AL, Yarovinsky F.

Proc Natl Acad Sci U S A. 2011 Jan 4;108(1):278-83. doi: 10.1073/pnas.1011549108. Epub 2010 Dec 20.


Effective induction of protective systemic immunity with nasally administered vaccines adjuvanted with IL-1.

Gwinn WM, Kirwan SM, Wang SH, Ashcraft KA, Sparks NL, Doil CR, Tlusty TG, Casey LS, Hollingshead SK, Briles DE, Dondero RS, Hickey AJ, Foster WM, Staats HF.

Vaccine. 2010 Oct 4;28(42):6901-14. doi: 10.1016/j.vaccine.2010.08.006. Epub 2010 Aug 17. Erratum in: Vaccine. 2011 Mar 24;29(15):2821.


Neutrophils influence the level of antigen presentation during the immune response to protein antigens in adjuvants.

Yang CW, Strong BS, Miller MJ, Unanue ER.

J Immunol. 2010 Sep 1;185(5):2927-34. doi: 10.4049/jimmunol.1001289. Epub 2010 Aug 2.


Mast cells contribute to the mucosal adjuvant effect of CTA1-DD after IgG-complex formation.

Fang Y, Larsson L, Mattsson J, Lycke N, Xiang Z.

J Immunol. 2010 Sep 1;185(5):2935-41. doi: 10.4049/jimmunol.1000589. Epub 2010 Jul 30.


Cutting edge: polyinosinic:polycytidylic acid boosts the generation of memory CD8 T cells through melanoma differentiation-associated protein 5 expressed in stromal cells.

Wang Y, Cella M, Gilfillan S, Colonna M.

J Immunol. 2010 Mar 15;184(6):2751-5. doi: 10.4049/jimmunol.0903201. Epub 2010 Feb 17.


Synthetic cationic peptide IDR-1002 provides protection against bacterial infections through chemokine induction and enhanced leukocyte recruitment.

Nijnik A, Madera L, Ma S, Waldbrook M, Elliott MR, Easton DM, Mayer ML, Mullaly SC, Kindrachuk J, Jenssen H, Hancock RE.

J Immunol. 2010 Mar 1;184(5):2539-50. doi: 10.4049/jimmunol.0901813. Epub 2010 Jan 27.


Interleukin-1 (IL-1) pathway.

Weber A, Wasiliew P, Kracht M.

Sci Signal. 2010 Jan 19;3(105):cm1. doi: 10.1126/scisignal.3105cm1. Review.


Intranasal immunization promotes th17 immune responses.

Zygmunt BM, Rharbaoui F, Groebe L, Guzman CA.

J Immunol. 2009 Dec 1;183(11):6933-8. doi: 10.4049/jimmunol.0901144. Epub 2009 Nov 4.


Essential and synergistic roles of IL1 and IL6 in human Th17 differentiation directed by TLR ligand-activated dendritic cells.

Benwell RK, Lee DR.

Clin Immunol. 2010 Feb;134(2):178-87. doi: 10.1016/j.clim.2009.09.013. Epub 2009 Oct 24.


T-helper 1 and T-helper 2 adjuvants induce distinct differences in the magnitude, quality and kinetics of the early inflammatory response at the site of injection.

Korsholm KS, Petersen RV, Agger EM, Andersen P.

Immunology. 2010 Jan;129(1):75-86. doi: 10.1111/j.1365-2567.2009.03164.x. Epub 2009 Jul 14.


Transient facial nerve paralysis (Bell's palsy) following intranasal delivery of a genetically detoxified mutant of Escherichia coli heat labile toxin.

Lewis DJ, Huo Z, Barnett S, Kromann I, Giemza R, Galiza E, Woodrow M, Thierry-Carstensen B, Andersen P, Novicki D, Del Giudice G, Rappuoli R.

PLoS One. 2009 Sep 16;4(9):e6999. doi: 10.1371/journal.pone.0006999.


Alum induces innate immune responses through macrophage and mast cell sensors, but these sensors are not required for alum to act as an adjuvant for specific immunity.

McKee AS, Munks MW, MacLeod MK, Fleenor CJ, Van Rooijen N, Kappler JW, Marrack P.

J Immunol. 2009 Oct 1;183(7):4403-14. doi: 10.4049/jimmunol.0900164. Epub 2009 Sep 4.


Dendritic cells require a systemic type I interferon response to mature and induce CD4+ Th1 immunity with poly IC as adjuvant.

Longhi MP, Trumpfheller C, Idoyaga J, Caskey M, Matos I, Kluger C, Salazar AM, Colonna M, Steinman RM.

J Exp Med. 2009 Jul 6;206(7):1589-602. doi: 10.1084/jem.20090247. Epub 2009 Jun 29.


TGF-beta promotes Th17 cell development through inhibition of SOCS3.

Qin H, Wang L, Feng T, Elson CO, Niyongere SA, Lee SJ, Reynolds SL, Weaver CT, Roarty K, Serra R, Benveniste EN, Cong Y.

J Immunol. 2009 Jul 1;183(1):97-105. doi: 10.4049/jimmunol.0801986. Epub 2009 Jun 17.


The mast cell activator compound 48/80 is safe and effective when used as an adjuvant for intradermal immunization with Bacillus anthracis protective antigen.

McGowen AL, Hale LP, Shelburne CP, Abraham SN, Staats HF.

Vaccine. 2009 Jun 2;27(27):3544-52. doi: 10.1016/j.vaccine.2009.03.069. Epub 2009 Apr 14.


Critical regulation of early Th17 cell differentiation by interleukin-1 signaling.

Chung Y, Chang SH, Martinez GJ, Yang XO, Nurieva R, Kang HS, Ma L, Watowich SS, Jetten AM, Tian Q, Dong C.

Immunity. 2009 Apr 17;30(4):576-87. doi: 10.1016/j.immuni.2009.02.007. Epub 2009 Apr 9.


IL-1 acts directly on CD4 T cells to enhance their antigen-driven expansion and differentiation.

Ben-Sasson SZ, Hu-Li J, Quiel J, Cauchetaux S, Ratner M, Shapira I, Dinarello CA, Paul WE.

Proc Natl Acad Sci U S A. 2009 Apr 28;106(17):7119-24. doi: 10.1073/pnas.0902745106. Epub 2009 Apr 9.

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