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Items: 1 to 20 of 58

1.

SIRT3 deacetylase: the Jekyll and Hyde sirtuin.

Silberman DM, Mostoslavsky R.

EMBO Rep. 2011 Jul 8;12(8):746-7. doi: 10.1038/embor.2011.147. No abstract available.

2.

SIRT3-dependent deacetylation exacerbates acetaminophen hepatotoxicity.

Lu Z, Bourdi M, Li JH, Aponte AM, Chen Y, Lombard DB, Gucek M, Pohl LR, Sack MN.

EMBO Rep. 2011 Jul 1;12(8):840-6. doi: 10.1038/embor.2011.121.

3.

The SirT3 divining rod points to oxidative stress.

Bell EL, Guarente L.

Mol Cell. 2011 Jun 10;42(5):561-8. doi: 10.1016/j.molcel.2011.05.008. Review.

4.

Autoacetylation of the histone acetyltransferase Rtt109.

Albaugh BN, Arnold KM, Lee S, Denu JM.

J Biol Chem. 2011 Jul 15;286(28):24694-701. doi: 10.1074/jbc.M111.251579. Epub 2011 May 23.

5.

Histone acetyltransferases are crucial regulators in NF-κB mediated inflammation.

Ghizzoni M, Haisma HJ, Maarsingh H, Dekker FJ.

Drug Discov Today. 2011 Jun;16(11-12):504-11. doi: 10.1016/j.drudis.2011.03.009. Epub 2011 Apr 6. Review.

6.

4-Hydroxynonenal inhibits SIRT3 via thiol-specific modification.

Fritz KS, Galligan JJ, Smathers RL, Roede JR, Shearn CT, Reigan P, Petersen DR.

Chem Res Toxicol. 2011 May 16;24(5):651-62. doi: 10.1021/tx100355a. Epub 2011 Apr 14.

7.

Acetylation of MnSOD directs enzymatic activity responding to cellular nutrient status or oxidative stress.

Ozden O, Park SH, Kim HS, Jiang H, Coleman MC, Spitz DR, Gius D.

Aging (Albany NY). 2011 Feb;3(2):102-7. Review.

8.

Sirt3 promotes the urea cycle and fatty acid oxidation during dietary restriction.

Hallows WC, Yu W, Smith BC, Devries MK, Ellinger JJ, Someya S, Shortreed MR, Prolla T, Markley JL, Smith LM, Zhao S, Guan KL, Denu JM.

Mol Cell. 2011 Jan 21;41(2):139-49. doi: 10.1016/j.molcel.2011.01.002. Erratum in: Mol Cell. 2011 Feb 18;41(4):493. Devires, Mark K [corrected to Devries, Mark K].

9.

Epigenetic mechanisms in inflammation.

Bayarsaihan D.

J Dent Res. 2011 Jan;90(1):9-17. doi: 10.1177/0022034510378683. Review.

10.

Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress.

Tao R, Coleman MC, Pennington JD, Ozden O, Park SH, Jiang H, Kim HS, Flynn CR, Hill S, Hayes McDonald W, Olivier AK, Spitz DR, Gius D.

Mol Cell. 2010 Dec 22;40(6):893-904. doi: 10.1016/j.molcel.2010.12.013.

11.

HDAC inhibitors and cancer therapy.

Atadja PW.

Prog Drug Res. 2011;67:175-95. Review.

PMID:
21141730
12.

Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation.

Qiu X, Brown K, Hirschey MD, Verdin E, Chen D.

Cell Metab. 2010 Dec 1;12(6):662-7. doi: 10.1016/j.cmet.2010.11.015.

13.

SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production.

Shimazu T, Hirschey MD, Hua L, Dittenhafer-Reed KE, Schwer B, Lombard DB, Li Y, Bunkenborg J, Alt FW, Denu JM, Jacobson MP, Verdin E.

Cell Metab. 2010 Dec 1;12(6):654-61. doi: 10.1016/j.cmet.2010.11.003.

14.

Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction.

Someya S, Yu W, Hallows WC, Xu J, Vann JM, Leeuwenburgh C, Tanokura M, Denu JM, Prolla TA.

Cell. 2010 Nov 24;143(5):802-12. doi: 10.1016/j.cell.2010.10.002.

15.

Histone modifications and cancer.

Sawan C, Herceg Z.

Adv Genet. 2010;70:57-85. doi: 10.1016/B978-0-12-380866-0.60003-4. Review.

PMID:
20920745
16.

Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling.

Verdin E, Hirschey MD, Finley LW, Haigis MC.

Trends Biochem Sci. 2010 Dec;35(12):669-75. doi: 10.1016/j.tibs.2010.07.003. Epub 2010 Sep 20. Review.

17.

Silencing of cytosolic NADP+-dependent isocitrate dehydrogenase gene enhances ethanol-induced toxicity in HepG2 cells.

Yang ES, Lee SM, Park JW.

Arch Pharm Res. 2010 Jul;33(7):1065-71. doi: 10.1007/s12272-010-0713-4. Epub 2010 Jul 27.

PMID:
20661717
18.

Acetate, the key modulator of inflammatory responses in acute alcoholic hepatitis.

Kendrick SF, O'Boyle G, Mann J, Zeybel M, Palmer J, Jones DE, Day CP.

Hepatology. 2010 Jun;51(6):1988-97. doi: 10.1002/hep.23572.

PMID:
20232292
19.

SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation.

Hirschey MD, Shimazu T, Goetzman E, Jing E, Schwer B, Lombard DB, Grueter CA, Harris C, Biddinger S, Ilkayeva OR, Stevens RD, Li Y, Saha AK, Ruderman NB, Bain JR, Newgard CB, Farese RV Jr, Alt FW, Kahn CR, Verdin E.

Nature. 2010 Mar 4;464(7285):121-5. doi: 10.1038/nature08778.

20.

Sirtuin chemical mechanisms.

Sauve AA.

Biochim Biophys Acta. 2010 Aug;1804(8):1591-603. doi: 10.1016/j.bbapap.2010.01.021. Epub 2010 Feb 2. Review.

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