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Items: 1 to 20 of 50

1.

G-quadruplexes: selective DNA targeting for cancer therapeutics?

Miller KM, Rodriguez R.

Expert Rev Clin Pharmacol. 2011 Mar;4(2):139-42. doi: 10.1586/ecp.11.4. No abstract available.

PMID:
22115396
2.

A single-molecule platform for investigation of interactions between G-quadruplexes and small-molecule ligands.

Koirala D, Dhakal S, Ashbridge B, Sannohe Y, Rodriguez R, Sugiyama H, Balasubramanian S, Mao H.

Nat Chem. 2011 Aug 28;3(10):782-7. doi: 10.1038/nchem.1126.

3.

DNA replication through G-quadruplex motifs is promoted by the Saccharomyces cerevisiae Pif1 DNA helicase.

Paeschke K, Capra JA, Zakian VA.

Cell. 2011 May 27;145(5):678-91. doi: 10.1016/j.cell.2011.04.015.

4.

Epigenetic instability due to defective replication of structured DNA.

Sarkies P, Reams C, Simpson LJ, Sale JE.

Mol Cell. 2010 Dec 10;40(5):703-13. doi: 10.1016/j.molcel.2010.11.009.

5.

Small-molecule-mediated G-quadruplex isolation from human cells.

Müller S, Kumari S, Rodriguez R, Balasubramanian S.

Nat Chem. 2010 Dec;2(12):1095-8. doi: 10.1038/nchem.842. Epub 2010 Oct 10.

6.

ATR-X syndrome protein targets tandem repeats and influences allele-specific expression in a size-dependent manner.

Law MJ, Lower KM, Voon HP, Hughes JR, Garrick D, Viprakasit V, Mitson M, De Gobbi M, Marra M, Morris A, Abbott A, Wilder SP, Taylor S, Santos GM, Cross J, Ayyub H, Jones S, Ragoussis J, Rhodes D, Dunham I, Higgs DR, Gibbons RJ.

Cell. 2010 Oct 29;143(3):367-78. doi: 10.1016/j.cell.2010.09.023.

7.

The DNA damage response: making it safe to play with knives.

Ciccia A, Elledge SJ.

Mol Cell. 2010 Oct 22;40(2):179-204. doi: 10.1016/j.molcel.2010.09.019. Review.

8.

PARP1 is activated at telomeres upon G4 stabilization: possible target for telomere-based therapy.

Salvati E, Scarsella M, Porru M, Rizzo A, Iachettini S, Tentori L, Graziani G, D'Incalci M, Stevens MF, Orlandi A, Passeri D, Gilson E, Zupi G, Leonetti C, Biroccio A.

Oncogene. 2010 Nov 25;29(47):6280-93. doi: 10.1038/onc.2010.344. Epub 2010 Aug 30.

PMID:
20802516
9.

Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining.

Miller KM, Tjeertes JV, Coates J, Legube G, Polo SE, Britton S, Jackson SP.

Nat Struct Mol Biol. 2010 Sep;17(9):1144-51. doi: 10.1038/nsmb.1899. Epub 2010 Aug 29.

10.

Deciphering the chromatin landscape induced around DNA double strand breaks.

Massip L, Caron P, Iacovoni JS, Trouche D, Legube G.

Cell Cycle. 2010 Aug 1;9(15):2963-72. doi: 10.4161/cc.9.15.12412.

PMID:
20714222
11.

ATM-dependent chromatin changes silence transcription in cis to DNA double-strand breaks.

Shanbhag NM, Rafalska-Metcalf IU, Balane-Bolivar C, Janicki SM, Greenberg RA.

Cell. 2010 Jun 11;141(6):970-81. doi: 10.1016/j.cell.2010.04.038.

12.

Human Pif1 helicase is a G-quadruplex DNA-binding protein with G-quadruplex DNA-unwinding activity.

Sanders CM.

Biochem J. 2010 Aug 15;430(1):119-28. doi: 10.1042/BJ20100612.

PMID:
20524933
13.

The role of supercoiling in transcriptional control of MYC and its importance in molecular therapeutics.

Brooks TA, Hurley LH.

Nat Rev Cancer. 2009 Dec;9(12):849-61. doi: 10.1038/nrc2733. Epub 2009 Nov 12. Review.

PMID:
19907434
14.

The DNA-damage response in human biology and disease.

Jackson SP, Bartek J.

Nature. 2009 Oct 22;461(7267):1071-8. doi: 10.1038/nature08467. Review.

15.

Src kinases as therapeutic targets for cancer.

Kim LC, Song L, Haura EB.

Nat Rev Clin Oncol. 2009 Oct;6(10):587-95. doi: 10.1038/nrclinonc.2009.129. Review.

PMID:
19787002
16.

Anticancer activity of CX-3543: a direct inhibitor of rRNA biogenesis.

Drygin D, Siddiqui-Jain A, O'Brien S, Schwaebe M, Lin A, Bliesath J, Ho CB, Proffitt C, Trent K, Whitten JP, Lim JK, Von Hoff D, Anderes K, Rice WG.

Cancer Res. 2009 Oct 1;69(19):7653-61. doi: 10.1158/0008-5472.CAN-09-1304. Epub 2009 Sep 8.

17.

An alternative DNA structure is necessary for pilin antigenic variation in Neisseria gonorrhoeae.

Cahoon LA, Seifert HS.

Science. 2009 Aug 7;325(5941):764-7. doi: 10.1126/science.1175653.

18.

Dasatinib synergizes with doxorubicin to block growth, migration, and invasion of breast cancer cells.

Pichot CS, Hartig SM, Xia L, Arvanitis C, Monisvais D, Lee FY, Frost JA, Corey SJ.

Br J Cancer. 2009 Jul 7;101(1):38-47. doi: 10.1038/sj.bjc.6605101. Epub 2009 Jun 9.

19.

Fast and accurate short read alignment with Burrows-Wheeler transform.

Li H, Durbin R.

Bioinformatics. 2009 Jul 15;25(14):1754-60. doi: 10.1093/bioinformatics/btp324. Epub 2009 May 18.

20.

The yeast Pif1 helicase prevents genomic instability caused by G-quadruplex-forming CEB1 sequences in vivo.

Ribeyre C, Lopes J, Boulé JB, Piazza A, Guédin A, Zakian VA, Mergny JL, Nicolas A.

PLoS Genet. 2009 May;5(5):e1000475. doi: 10.1371/journal.pgen.1000475. Epub 2009 May 8.

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