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Items: 1 to 20 of 85

1.

SHP-2/PTPN11 mediates gliomagenesis driven by PDGFRA and INK4A/ARF aberrations in mice and humans.

Liu KW, Feng H, Bachoo R, Kazlauskas A, Smith EM, Symes K, Hamilton RL, Nagane M, Nishikawa R, Hu B, Cheng SY.

J Clin Invest. 2011 Mar;121(3):905-17. doi: 10.1172/JCI43690.

2.

Heparan sulfate regulates VEGF165- and VEGF121-mediated vascular hyperpermeability.

Xu D, Fuster MM, Lawrence R, Esko JD.

J Biol Chem. 2011 Jan 7;286(1):737-45. doi: 10.1074/jbc.M110.177006. Epub 2010 Oct 25.

3.

PDGFRA gene rearrangements are frequent genetic events in PDGFRA-amplified glioblastomas.

Ozawa T, Brennan CW, Wang L, Squatrito M, Sasayama T, Nakada M, Huse JT, Pedraza A, Utsuki S, Yasui Y, Tandon A, Fomchenko EI, Oka H, Levine RL, Fujii K, Ladanyi M, Holland EC.

Genes Dev. 2010 Oct 1;24(19):2205-18. doi: 10.1101/gad.1972310.

4.

Expression regulation and function of heparan sulfate 6-O-endosulfatases in the spermatogonial stem cell niche.

Langsdorf A, Schumacher V, Shi X, Tran T, Zaia J, Jain S, Taglienti M, Kreidberg JA, Fine A, Ai X.

Glycobiology. 2011 Feb;21(2):152-61. doi: 10.1093/glycob/cwq133. Epub 2010 Sep 20.

5.

Sulf-2: an extracellular modulator of cell signaling and a cancer target candidate.

Rosen SD, Lemjabbar-Alaoui H.

Expert Opin Ther Targets. 2010 Sep;14(9):935-49. doi: 10.1517/14728222.2010.504718. Review.

6.

Differential involvement of the extracellular 6-O-endosulfatases Sulf1 and Sulf2 in brain development and neuronal and behavioural plasticity.

Kalus I, Salmen B, Viebahn C, von Figura K, Schmitz D, D'Hooge R, Dierks T.

J Cell Mol Med. 2009 Nov-Dec;13(11-12):4505-21. doi: 10.1111/j.1582-4934.2008.00558.x.

7.

Matrix metalloproteinases: regulators of the tumor microenvironment.

Kessenbrock K, Plaks V, Werb Z.

Cell. 2010 Apr 2;141(1):52-67. doi: 10.1016/j.cell.2010.03.015. Review.

8.

Restriction of receptor movement alters cellular response: physical force sensing by EphA2.

Salaita K, Nair PM, Petit RS, Neve RM, Das D, Gray JW, Groves JT.

Science. 2010 Mar 12;327(5971):1380-5. doi: 10.1126/science.1181729.

9.

A multigene predictor of outcome in glioblastoma.

Colman H, Zhang L, Sulman EP, McDonald JM, Shooshtari NL, Rivera A, Popoff S, Nutt CL, Louis DN, Cairncross JG, Gilbert MR, Phillips HS, Mehta MP, Chakravarti A, Pelloski CE, Bhat K, Feuerstein BG, Jenkins RB, Aldape K.

Neuro Oncol. 2010 Jan;12(1):49-57. doi: 10.1093/neuonc/nop007. Epub 2009 Oct 20.

10.

Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1.

Verhaak RG, Hoadley KA, Purdom E, Wang V, Qi Y, Wilkerson MD, Miller CR, Ding L, Golub T, Mesirov JP, Alexe G, Lawrence M, O'Kelly M, Tamayo P, Weir BA, Gabriel S, Winckler W, Gupta S, Jakkula L, Feiler HS, Hodgson JG, James CD, Sarkaria JN, Brennan C, Kahn A, Spellman PT, Wilson RK, Speed TP, Gray JW, Meyerson M, Getz G, Perou CM, Hayes DN; Cancer Genome Atlas Research Network..

Cancer Cell. 2010 Jan 19;17(1):98-110. doi: 10.1016/j.ccr.2009.12.020.

11.

Synthesis and biological evaluation of polysulfated oligosaccharide glycosides as inhibitors of angiogenesis and tumor growth.

Johnstone KD, Karoli T, Liu L, Dredge K, Copeman E, Li CP, Davis K, Hammond E, Bytheway I, Kostewicz E, Chiu FC, Shackleford DM, Charman SA, Charman WN, Harenberg J, Gonda TJ, Ferro V.

J Med Chem. 2010 Feb 25;53(4):1686-99. doi: 10.1021/jm901449m.

PMID:
20128596
12.

HpSulf, a heparan sulfate 6-O-endosulfatase, is involved in the regulation of VEGF signaling during sea urchin development.

Fujita K, Takechi E, Sakamoto N, Sumiyoshi N, Izumi S, Miyamoto T, Matsuura S, Tsurugaya T, Akasaka K, Yamamoto T.

Mech Dev. 2010 Apr;127(3-4):235-45. doi: 10.1016/j.mod.2009.12.001. Epub 2009 Dec 29.

13.

PDGF-A interactions with fibronectin reveal a critical role for heparan sulfate in directed cell migration during Xenopus gastrulation.

Smith EM, Mitsi M, Nugent MA, Symes K.

Proc Natl Acad Sci U S A. 2009 Dec 22;106(51):21683-8. doi: 10.1073/pnas.0902510106. Epub 2009 Dec 4.

14.

Multicentre phase I/II study of PI-88, a heparanase inhibitor in combination with docetaxel in patients with metastatic castrate-resistant prostate cancer.

Khasraw M, Pavlakis N, McCowatt S, Underhill C, Begbie S, de Souza P, Boyce A, Parnis F, Lim V, Harvie R, Marx G.

Ann Oncol. 2010 Jun;21(6):1302-7. doi: 10.1093/annonc/mdp524. Epub 2009 Nov 16.

PMID:
19917571
15.

Glioblastoma subclasses can be defined by activity among signal transduction pathways and associated genomic alterations.

Brennan C, Momota H, Hambardzumyan D, Ozawa T, Tandon A, Pedraza A, Holland E.

PLoS One. 2009 Nov 13;4(11):e7752. doi: 10.1371/journal.pone.0007752.

16.

Sulf-2, a heparan sulfate endosulfatase, promotes human lung carcinogenesis.

Lemjabbar-Alaoui H, van Zante A, Singer MS, Xue Q, Wang YQ, Tsay D, He B, Jablons DM, Rosen SD.

Oncogene. 2010 Feb 4;29(5):635-46. doi: 10.1038/onc.2009.365. Epub 2009 Oct 26.

17.

Direct detection of HSulf-1 and HSulf-2 activities on extracellular heparan sulfate and their inhibition by PI-88.

Hossain MM, Hosono-Fukao T, Tang R, Sugaya N, van Kuppevelt TH, Jenniskens GJ, Kimata K, Rosen SD, Uchimura K.

Glycobiology. 2010 Feb;20(2):175-86. doi: 10.1093/glycob/cwp159. Epub 2009 Oct 12.

18.

Identification of SULF2 as a novel transcriptional target of p53 by use of integrated genomic analyses.

Chau BN, Diaz RL, Saunders MA, Cheng C, Chang AN, Warrener P, Bradshaw J, Linsley PS, Cleary MA.

Cancer Res. 2009 Feb 15;69(4):1368-74. doi: 10.1158/0008-5472.CAN-08-2742. Epub 2009 Feb 3.

19.

Downregulation of Wnt2 and beta-catenin by siRNA suppresses malignant glioma cell growth.

Pu P, Zhang Z, Kang C, Jiang R, Jia Z, Wang G, Jiang H.

Cancer Gene Ther. 2009 Apr;16(4):351-61. doi: 10.1038/cgt.2008.78. Epub 2008 Oct 24.

PMID:
18949017
20.

Comprehensive genomic characterization defines human glioblastoma genes and core pathways.

Cancer Genome Atlas Research Network..

Nature. 2008 Oct 23;455(7216):1061-8. doi: 10.1038/nature07385. Epub 2008 Sep 4. Erratum in: Nature. 2013 Feb 28;494(7438):506.

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