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Items: 1 to 20 of 46


Inflammatory links between obesity and metabolic disease.

Lumeng CN, Saltiel AR.

J Clin Invest. 2011 Jun;121(6):2111-7. doi: 10.1172/JCI57132. Epub 2011 Jun 1. Review.


Surfactant protein C mutations are the basis of a significant portion of adult familial pulmonary fibrosis in a dutch cohort.

van Moorsel CH, van Oosterhout MF, Barlo NP, de Jong PA, van der Vis JJ, Ruven HJ, van Es HW, van den Bosch JM, Grutters JC.

Am J Respir Crit Care Med. 2010 Dec 1;182(11):1419-25. doi: 10.1164/rccm.200906-0953OC. Epub 2010 Jul 23.


LPCAT1 regulates surfactant phospholipid synthesis and is required for transitioning to air breathing in mice.

Bridges JP, Ikegami M, Brilli LL, Chen X, Mason RJ, Shannon JM.

J Clin Invest. 2010 May;120(5):1736-48. doi: 10.1172/JCI38061. Epub 2010 Apr 19. Erratum in: J Clin Invest. 2010 Jun 1;120(6):2248.


Review: The intersection of surfactant homeostasis and innate host defense of the lung: lessons from newborn infants.

Whitsett JA.

Innate Immun. 2010 Jun;16(3):138-42. doi: 10.1177/1753425910366879. Epub 2010 Mar 29. Review.


Conditional deletion of Abca3 in alveolar type II cells alters surfactant homeostasis in newborn and adult mice.

Besnard V, Matsuzaki Y, Clark J, Xu Y, Wert SE, Ikegami M, Stahlman MT, Weaver TE, Hunt AN, Postle AD, Whitsett JA.

Am J Physiol Lung Cell Mol Physiol. 2010 May;298(5):L646-59. doi: 10.1152/ajplung.00409.2009. Epub 2010 Feb 26.


Fatty diabetic lung: altered alveolar structure and surfactant protein expression.

Foster DJ, Ravikumar P, Bellotto DJ, Unger RH, Hsia CC.

Am J Physiol Lung Cell Mol Physiol. 2010 Mar;298(3):L392-403. doi: 10.1152/ajplung.00041.2009. Epub 2010 Jan 8.


Alveolar surfactant homeostasis and the pathogenesis of pulmonary disease.

Whitsett JA, Wert SE, Weaver TE.

Annu Rev Med. 2010;61:105-19. doi: 10.1146/ Review.


Deletion of Scap in alveolar type II cells influences lung lipid homeostasis and identifies a compensatory role for pulmonary lipofibroblasts.

Besnard V, Wert SE, Stahlman MT, Postle AD, Xu Y, Ikegami M, Whitsett JA.

J Biol Chem. 2009 Feb 6;284(6):4018-30. doi: 10.1074/jbc.M805388200. Epub 2008 Dec 11.


STAT-3 regulates surfactant phospholipid homeostasis in normal lung and during endotoxin-mediated lung injury.

Ikegami M, Falcone A, Whitsett JA.

J Appl Physiol (1985). 2008 Jun;104(6):1753-60. doi: 10.1152/japplphysiol.00875.2007. Epub 2008 Mar 27.


Loss of ABCG1 results in chronic pulmonary inflammation.

Baldán A, Gomes AV, Ping P, Edwards PA.

J Immunol. 2008 Mar 1;180(5):3560-8.


Sterol response element binding protein and thyroid transcription factor-1 (Nkx2.1) regulate Abca3 gene expression.

Besnard V, Xu Y, Whitsett JA.

Am J Physiol Lung Cell Mol Physiol. 2007 Dec;293(6):L1395-405. Epub 2007 Sep 21.


An elevated level of cholesterol impairs self-assembly of pulmonary surfactant into a functional film.

Leonenko Z, Gill S, Baoukina S, Monticelli L, Doehner J, Gunasekara L, Felderer F, Rodenstein M, Eng LM, Amrein M.

Biophys J. 2007 Jul 15;93(2):674-83. Epub 2007 May 4.


Isomer specific effects of Conjugated Linoleic Acid on macrophage ABCG1 transcription by a SREBP-1c dependent mechanism.

Ecker J, Langmann T, Moehle C, Schmitz G.

Biochem Biophys Res Commun. 2007 Jan 19;352(3):805-11. Epub 2006 Nov 27.


Calcineurin/Nfat signaling is required for perinatal lung maturation and function.

Davé V, Childs T, Xu Y, Ikegami M, Besnard V, Maeda Y, Wert SE, Neilson JR, Crabtree GR, Whitsett JA.

J Clin Invest. 2006 Oct;116(10):2597-609. Epub 2006 Sep 21.


Lipidomics of cellular and secreted phospholipids from differentiated human fetal type II alveolar epithelial cells.

Postle AD, Gonzales LW, Bernhard W, Clark GT, Godinez MH, Godinez RI, Ballard PL.

J Lipid Res. 2006 Jun;47(6):1322-31. Epub 2006 Mar 2.


C/EBPalpha is required for lung maturation at birth.

Martis PC, Whitsett JA, Xu Y, Perl AK, Wan H, Ikegami M.

Development. 2006 Mar;133(6):1155-64. Epub 2006 Feb 8.


Schoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteins.

Engelking LJ, Liang G, Hammer RE, Takaishi K, Kuriyama H, Evers BM, Li WP, Horton JD, Goldstein JL, Brown MS.

J Clin Invest. 2005 Sep;115(9):2489-98. Epub 2005 Aug 11.


Conditional recombination reveals distinct subsets of epithelial cells in trachea, bronchi, and alveoli.

Perl AK, Wert SE, Loudy DE, Shan Z, Blair PA, Whitsett JA.

Am J Respir Cell Mol Biol. 2005 Nov;33(5):455-62. Epub 2005 Jul 29.

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