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Items: 1 to 20 of 44


Chemical genetic approach for kinase-substrate mapping by covalent capture of thiophosphopeptides and analysis by mass spectrometry.

Hertz NT, Wang BT, Allen JJ, Zhang C, Dar AC, Burlingame AL, Shokat KM.

Curr Protoc Chem Biol. 2010 Mar 1;2(1):15-36. doi: 10.1002/9780470559277.ch090201.


PHLDA1 is a crucial negative regulator and effector of Aurora A kinase in breast cancer.

Johnson EO, Chang KH, de Pablo Y, Ghosh S, Mehta R, Badve S, Shah K.

J Cell Sci. 2011 Aug 15;124(Pt 16):2711-22. doi: 10.1242/jcs.084970.


Quantitative phosphoproteomics identifies substrates and functional modules of Aurora and Polo-like kinase activities in mitotic cells.

Kettenbach AN, Schweppe DK, Faherty BK, Pechenick D, Pletnev AA, Gerber SA.

Sci Signal. 2011 Jun 28;4(179):rs5. doi: 10.1126/scisignal.2001497.


Spatial exclusivity combined with positive and negative selection of phosphorylation motifs is the basis for context-dependent mitotic signaling.

Alexander J, Lim D, Joughin BA, Hegemann B, Hutchins JR, Ehrenberger T, Ivins F, Sessa F, Hudecz O, Nigg EA, Fry AM, Musacchio A, Stukenberg PT, Mechtler K, Peters JM, Smerdon SJ, Yaffe MB.

Sci Signal. 2011 Jun 28;4(179):ra42. doi: 10.1126/scisignal.2001796.


A positive feedback loop involving Haspin and Aurora B promotes CPC accumulation at centromeres in mitosis.

Wang F, Ulyanova NP, van der Waal MS, Patnaik D, Lens SM, Higgins JM.

Curr Biol. 2011 Jun 21;21(12):1061-9. doi: 10.1016/j.cub.2011.05.016. Epub 2011 Jun 9.


Modification site localization scoring integrated into a search engine.

Baker PR, Trinidad JC, Chalkley RJ.

Mol Cell Proteomics. 2011 Jul;10(7):M111.008078. doi: 10.1074/mcp.M111.008078. Epub 2011 Apr 13.


Shared and separate functions of polo-like kinases and aurora kinases in cancer.

Lens SM, Voest EE, Medema RH.

Nat Rev Cancer. 2010 Dec;10(12):825-41. doi: 10.1038/nrc2964. Epub 2010 Nov 24. Review.


Identification of Myb-binding protein 1A (MYBBP1A) as a novel substrate for aurora B kinase.

Perrera C, Colombo R, Valsasina B, Carpinelli P, Troiani S, Modugno M, Gianellini L, Cappella P, Isacchi A, Moll J, Rusconi L.

J Biol Chem. 2010 Apr 16;285(16):11775-85. doi: 10.1074/jbc.M109.068312. Epub 2010 Feb 22.


Regulation of chromatin structure and function by HMGN proteins.

Postnikov Y, Bustin M.

Biochim Biophys Acta. 2010 Jan-Feb;1799(1-2):62-8. doi: 10.1016/j.bbagrm.2009.11.016. Epub 2009 Nov 27. Review.


The nucleosome-binding protein HMGN2 modulates global genome repair.

Subramanian M, Gonzalez RW, Patil H, Ueda T, Lim JH, Kraemer KH, Bustin M, Bergel M.

FEBS J. 2009 Nov;276(22):6646-57. doi: 10.1111/j.1742-4658.2009.07375.x. Epub 2009 Oct 16.


The interaction of NSBP1/HMGN5 with nucleosomes in euchromatin counteracts linker histone-mediated chromatin compaction and modulates transcription.

Rochman M, Postnikov Y, Correll S, Malicet C, Wincovitch S, Karpova TS, McNally JG, Wu X, Bubunenko NA, Grigoryev S, Bustin M.

Mol Cell. 2009 Sep 11;35(5):642-56. doi: 10.1016/j.molcel.2009.07.002.


Cdk1 negatively regulates midzone localization of the mitotic kinesin Mklp2 and the chromosomal passenger complex.

Hümmer S, Mayer TU.

Curr Biol. 2009 Apr 14;19(7):607-12. doi: 10.1016/j.cub.2009.02.046. Epub 2009 Mar 19.


Molecular basis of drug resistance in aurora kinases.

Girdler F, Sessa F, Patercoli S, Villa F, Musacchio A, Taylor S.

Chem Biol. 2008 Jun;15(6):552-62. doi: 10.1016/j.chembiol.2008.04.013.


Delineation of the protein module that anchors HMGN proteins to nucleosomes in the chromatin of living cells.

Ueda T, Catez F, Gerlitz G, Bustin M.

Mol Cell Biol. 2008 May;28(9):2872-83. doi: 10.1128/MCB.02181-07. Epub 2008 Feb 25.


Cell cycle-dependent binding of HMGN proteins to chromatin.

Cherukuri S, Hock R, Ueda T, Catez F, Rochman M, Bustin M.

Mol Biol Cell. 2008 May;19(5):1816-24. doi: 10.1091/mbc.E07-10-1018. Epub 2008 Feb 20.


Structure-activity relationship of S-trityl-L-cysteine analogues as inhibitors of the human mitotic kinesin Eg5.

Debonis S, Skoufias DA, Indorato RL, Liger F, Marquet B, Laggner C, Joseph B, Kozielski F.

J Med Chem. 2008 Mar 13;51(5):1115-25. doi: 10.1021/jm070606z. Epub 2008 Feb 12.


Design and use of analog-sensitive protein kinases.

Blethrow J, Zhang C, Shokat KM, Weiss EL.

Curr Protoc Mol Biol. 2004 May;Chapter 18:Unit 18.11. doi: 10.1002/0471142727.mb1811s66.


Covalent capture of kinase-specific phosphopeptides reveals Cdk1-cyclin B substrates.

Blethrow JD, Glavy JS, Morgan DO, Shokat KM.

Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1442-7. doi: 10.1073/pnas.0708966105. Epub 2008 Jan 30.


Recognizing and exploiting differences between RNAi and small-molecule inhibitors.

Weiss WA, Taylor SS, Shokat KM.

Nat Chem Biol. 2007 Dec;3(12):739-44. No abstract available.


A novel role for the Aurora B kinase in epigenetic marking of silent chromatin in differentiated postmitotic cells.

Sabbattini P, Canzonetta C, Sjoberg M, Nikic S, Georgiou A, Kemball-Cook G, Auner HW, Dillon N.

EMBO J. 2007 Nov 14;26(22):4657-69. Epub 2007 Oct 18.

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