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The PD-1/PD-L1 (B7-H1) pathway in chronic infection-induced cytotoxic T lymphocyte exhaustion.

Hofmeyer KA, Jeon H, Zang X.

J Biomed Biotechnol. 2011;2011:451694. doi: 10.1155/2011/451694. Epub 2011 Sep 25. Review.


Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection.

Jin HT, Anderson AC, Tan WG, West EE, Ha SJ, Araki K, Freeman GJ, Kuchroo VK, Ahmed R.

Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14733-8. doi: 10.1073/pnas.1009731107. Epub 2010 Aug 2.


Program death-1 signaling and regulatory T cells collaborate to resist the function of adoptively transferred cytotoxic T lymphocytes in advanced acute myeloid leukemia.

Zhou Q, Munger ME, Highfill SL, Tolar J, Weigel BJ, Riddle M, Sharpe AH, Vallera DA, Azuma M, Levine BL, June CH, Murphy WJ, Munn DH, Blazar BR.

Blood. 2010 Oct 7;116(14):2484-93. doi: 10.1182/blood-2010-03-275446. Epub 2010 Jun 22.


Intact NKG2D-independent function of NK cells chronically stimulated with the NKG2D ligand Rae-1.

Champsaur M, Beilke JN, Ogasawara K, Koszinowski UH, Jonjic S, Lanier LL.

J Immunol. 2010 Jul 1;185(1):157-65. doi: 10.4049/jimmunol.1000397. Epub 2010 Jun 7.


Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired.

Ahmadzadeh M, Johnson LA, Heemskerk B, Wunderlich JR, Dudley ME, White DE, Rosenberg SA.

Blood. 2009 Aug 20;114(8):1537-44. doi: 10.1182/blood-2008-12-195792. Epub 2009 May 7.


The common gamma-chain cytokines IL-2, IL-7, IL-15, and IL-21 induce the expression of programmed death-1 and its ligands.

Kinter AL, Godbout EJ, McNally JP, Sereti I, Roby GA, O'Shea MA, Fauci AS.

J Immunol. 2008 Nov 15;181(10):6738-46.


NKG2D-deficient mice are defective in tumor surveillance in models of spontaneous malignancy.

Guerra N, Tan YX, Joncker NT, Choy A, Gallardo F, Xiong N, Knoblaugh S, Cado D, Greenberg NM, Raulet DH.

Immunity. 2008 Apr;28(4):571-80. doi: 10.1016/j.immuni.2008.02.016. Erratum in: Immunity. 2008 May;28(5):723. Greenberg, Norman R [corrected to Greenberg, Norman M].


Regulatory and conventional CD4+ T cells show differential effects correlating with PD-1 and B7-H1 expression after immunotherapy.

Alderson KL, Zhou Q, Berner V, Wilkins DE, Weiss JM, Blazar BR, Welniak LA, Wiltrout RH, Redelman D, Murphy WJ.

J Immunol. 2008 Mar 1;180(5):2981-8.


Adaptive immunity maintains occult cancer in an equilibrium state.

Koebel CM, Vermi W, Swann JB, Zerafa N, Rodig SJ, Old LJ, Smyth MJ, Schreiber RD.

Nature. 2007 Dec 6;450(7171):903-7. Epub 2007 Nov 18.


IFN-gamma mediates CD4+ T-cell loss and impairs secondary antitumor responses after successful initial immunotherapy.

Berner V, Liu H, Zhou Q, Alderson KL, Sun K, Weiss JM, Back TC, Longo DL, Blazar BR, Wiltrout RH, Welniak LA, Redelman D, Murphy WJ.

Nat Med. 2007 Mar;13(3):354-60. Epub 2007 Mar 4.


NK cells use NKG2D to recognize a mouse renal cancer (Renca), yet require intercellular adhesion molecule-1 expression on the tumor cells for optimal perforin-dependent effector function.

Abdool K, Cretney E, Brooks AD, Kelly JM, Swann J, Shanker A, Bere EW Jr, Yokoyama WM, Ortaldo JR, Smyth MJ, Sayers TJ.

J Immunol. 2006 Aug 15;177(4):2575-83.


NKG2D in NK and T cell-mediated immunity.

Ogasawara K, Lanier LL.

J Clin Immunol. 2005 Nov;25(6):534-40. Review.


The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor.

Gasser S, Orsulic S, Brown EJ, Raulet DH.

Nature. 2005 Aug 25;436(7054):1186-90. Epub 2005 Jul 3.


PD-1 inhibits T-cell receptor induced phosphorylation of the ZAP70/CD3zeta signalosome and downstream signaling to PKCtheta.

Sheppard KA, Fitz LJ, Lee JM, Benander C, George JA, Wooters J, Qiu Y, Jussif JM, Carter LL, Wood CR, Chaudhary D.

FEBS Lett. 2004 Sep 10;574(1-3):37-41.


Role of NKG2D signaling in the cytotoxicity of activated and expanded CD8+ T cells.

Verneris MR, Karimi M, Baker J, Jayaswal A, Negrin RS.

Blood. 2004 Apr 15;103(8):3065-72. Epub 2003 Nov 20. Erratum in: Blood. 2015 Apr 16;125(16):2583. Karami, Mobin [corrected to Karimi, Mobin].


A novel ligand for the NKG2D receptor activates NK cells and macrophages and induces tumor immunity.

Diefenbach A, Hsia JK, Hsiung MY, Raulet DH.

Eur J Immunol. 2003 Feb;33(2):381-91.

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