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Items: 1 to 20 of 79

1.

Resveratrol inhibits mTOR signaling by promoting the interaction between mTOR and DEPTOR.

Liu M, Wilk SA, Wang A, Zhou L, Wang RH, Ogawa W, Deng C, Dong LQ, Liu F.

J Biol Chem. 2010 Nov 19;285(47):36387-94. doi: 10.1074/jbc.M110.169284.

2.

SIRT1 negatively regulates the mammalian target of rapamycin.

Ghosh HS, McBurney M, Robbins PD.

PLoS One. 2010 Feb 15;5(2):e9199. doi: 10.1371/journal.pone.0009199.

3.

Inhibition of mammalian S6 kinase by resveratrol suppresses autophagy.

Armour SM, Baur JA, Hsieh SN, Land-Bracha A, Thomas SM, Sinclair DA.

Aging (Albany NY). 2009 Jun 3;1(6):515-28.

4.

Resveratrol promotes autophagic cell death in chronic myelogenous leukemia cells via JNK-mediated p62/SQSTM1 expression and AMPK activation.

Puissant A, Robert G, Fenouille N, Luciano F, Cassuto JP, Raynaud S, Auberger P.

Cancer Res. 2010 Feb 1;70(3):1042-52. doi: 10.1158/0008-5472.CAN-09-3537.

5.

Resveratrol and rapamycin: are they anti-aging drugs?

Kaeberlein M.

Bioessays. 2010 Feb;32(2):96-9. doi: 10.1002/bies.200900171.

PMID:
20091754
6.

AMP-activated protein kinase signaling activation by resveratrol modulates amyloid-beta peptide metabolism.

Vingtdeux V, Giliberto L, Zhao H, Chandakkar P, Wu Q, Simon JE, Janle EM, Lobo J, Ferruzzi MG, Davies P, Marambaud P.

J Biol Chem. 2010 Mar 19;285(12):9100-13. doi: 10.1074/jbc.M109.060061.

7.

Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster.

Bjedov I, Toivonen JM, Kerr F, Slack C, Jacobson J, Foley A, Partridge L.

Cell Metab. 2010 Jan;11(1):35-46. doi: 10.1016/j.cmet.2009.11.010.

8.

SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1.

Pacholec M, Bleasdale JE, Chrunyk B, Cunningham D, Flynn D, Garofalo RS, Griffith D, Griffor M, Loulakis P, Pabst B, Qiu X, Stockman B, Thanabal V, Varghese A, Ward J, Withka J, Ahn K.

J Biol Chem. 2010 Mar 12;285(11):8340-51. doi: 10.1074/jbc.M109.088682.

9.

Metformin extends life span of HER-2/neu transgenic mice and in combination with melatonin inhibits growth of transplantable tumors in vivo.

Anisimov VN, Egormin PA, Piskunova TS, Popovich IG, Tyndyk ML, Yurova MN, Zabezhinski MA, Anikin IV, Karkach AS, Romanyukha AA.

Cell Cycle. 2010 Jan 1;9(1):188-97.

PMID:
20016287
10.

Target identification using drug affinity responsive target stability (DARTS).

Lomenick B, Hao R, Jonai N, Chin RM, Aghajan M, Warburton S, Wang J, Wu RP, Gomez F, Loo JA, Wohlschlegel JA, Vondriska TM, Pelletier J, Herschman HR, Clardy J, Clarke CF, Huang J.

Proc Natl Acad Sci U S A. 2009 Dec 22;106(51):21984-9. doi: 10.1073/pnas.0910040106.

11.

Calories and carcinogenesis: lessons learned from 30 years of calorie restriction research.

Hursting SD, Smith SM, Lashinger LM, Harvey AE, Perkins SN.

Carcinogenesis. 2010 Jan;31(1):83-9. doi: 10.1093/carcin/bgp280. Review.

12.

mTOR and cancer: many loops in one pathway.

Efeyan A, Sabatini DM.

Curr Opin Cell Biol. 2010 Apr;22(2):169-76. doi: 10.1016/j.ceb.2009.10.007.

13.

AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol.

Um JH, Park SJ, Kang H, Yang S, Foretz M, McBurney MW, Kim MK, Viollet B, Chung JH.

Diabetes. 2010 Mar;59(3):554-63. doi: 10.2337/db09-0482.

14.

Resveratrol modulates tumor cell proliferation and protein translation via SIRT1-dependent AMPK activation.

Lin JN, Lin VC, Rau KM, Shieh PC, Kuo DH, Shieh JC, Chen WJ, Tsai SC, Way TD.

J Agric Food Chem. 2010 Feb 10;58(3):1584-92. doi: 10.1021/jf9035782.

PMID:
19928762
15.

Resveratrol is not a direct activator of SIRT1 enzyme activity.

Beher D, Wu J, Cumine S, Kim KW, Lu SC, Atangan L, Wang M.

Chem Biol Drug Des. 2009 Dec;74(6):619-24. doi: 10.1111/j.1747-0285.2009.00901.x.

PMID:
19843076
16.

Rapamycin response in tumorigenic and non-tumorigenic hepatic cell lines.

Jimenez RH, Boylan JM, Lee JS, Francesconi M, Castellani G, Sanders JA, Gruppuso PA.

PLoS One. 2009 Oct 9;4(10):e7373. doi: 10.1371/journal.pone.0007373.

17.

mTOR signaling at a glance.

Laplante M, Sabatini DM.

J Cell Sci. 2009 Oct 15;122(Pt 20):3589-94. doi: 10.1242/jcs.051011. Review. No abstract available.

18.

4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila.

Zid BM, Rogers AN, Katewa SD, Vargas MA, Kolipinski MC, Lu TA, Benzer S, Kapahi P.

Cell. 2009 Oct 2;139(1):149-60. doi: 10.1016/j.cell.2009.07.034.

19.

Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.

Selman C, Tullet JM, Wieser D, Irvine E, Lingard SJ, Choudhury AI, Claret M, Al-Qassab H, Carmignac D, Ramadani F, Woods A, Robinson IC, Schuster E, Batterham RL, Kozma SC, Thomas G, Carling D, Okkenhaug K, Thornton JM, Partridge L, Gems D, Withers DJ.

Science. 2009 Oct 2;326(5949):140-4. doi: 10.1126/science.1177221. Erratum in: Science. 2011 Oct 7;334(6052):39.

20.

Translation initiation: a critical signalling node in cancer.

Robert F, Pelletier J.

Expert Opin Ther Targets. 2009 Nov;13(11):1279-93. doi: 10.1517/14728220903241625. Review.

PMID:
19705976
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