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Items: 1 to 20 of 49

1.

Interferon-γ-induced increases in intestinal epithelial macromolecular permeability requires the Src kinase Fyn.

Smyth D, Phan V, Wang A, McKay DM.

Lab Invest. 2011 May;91(5):764-77. doi: 10.1038/labinvest.2010.208. Epub 2011 Feb 14.

2.

Loss of guanylyl cyclase C (GCC) signaling leads to dysfunctional intestinal barrier.

Han X, Mann E, Gilbert S, Guan Y, Steinbrecher KA, Montrose MH, Cohen MB.

PLoS One. 2011 Jan 31;6(1):e16139. doi: 10.1371/journal.pone.0016139.

3.

Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.

Anderson CA, Boucher G, Lees CW, Franke A, D'Amato M, Taylor KD, Lee JC, Goyette P, Imielinski M, Latiano A, Lagacé C, Scott R, Amininejad L, Bumpstead S, Baidoo L, Baldassano RN, Barclay M, Bayless TM, Brand S, Büning C, Colombel JF, Denson LA, De Vos M, Dubinsky M, Edwards C, Ellinghaus D, Fehrmann RS, Floyd JA, Florin T, Franchimont D, Franke L, Georges M, Glas J, Glazer NL, Guthery SL, Haritunians T, Hayward NK, Hugot JP, Jobin G, Laukens D, Lawrance I, Lémann M, Levine A, Libioulle C, Louis E, McGovern DP, Milla M, Montgomery GW, Morley KI, Mowat C, Ng A, Newman W, Ophoff RA, Papi L, Palmieri O, Peyrin-Biroulet L, Panés J, Phillips A, Prescott NJ, Proctor DD, Roberts R, Russell R, Rutgeerts P, Sanderson J, Sans M, Schumm P, Seibold F, Sharma Y, Simms LA, Seielstad M, Steinhart AH, Targan SR, van den Berg LH, Vatn M, Verspaget H, Walters T, Wijmenga C, Wilson DC, Westra HJ, Xavier RJ, Zhao ZZ, Ponsioen CY, Andersen V, Torkvist L, Gazouli M, Anagnou NP, Karlsen TH, Kupcinskas L, Sventoraityte J, Mansfield JC, Kugathasan S, Silverberg MS, Halfvarson J, Rotter JI, Mathew CG, Griffiths AM, Gearry R, Ahmad T, Brant SR, Chamaillard M, Satsangi J, Cho JH, Schreiber S, Daly MJ, Barrett JC, Parkes M, Annese V, Hakonarson H, Radford-Smith G, Duerr RH, Vermeire S, Weersma RK, Rioux JD.

Nat Genet. 2011 Mar;43(3):246-52. doi: 10.1038/ng.764. Epub 2011 Feb 6. Erratum in: Nat Genet. 2011 Sep;43(9):919.

4.

Tight junction pore and leak pathways: a dynamic duo.

Shen L, Weber CR, Raleigh DR, Yu D, Turner JR.

Annu Rev Physiol. 2011;73:283-309. doi: 10.1146/annurev-physiol-012110-142150. Review.

5.

Loss of GM-CSF signalling in non-haematopoietic cells increases NSAID ileal injury.

Han X, Gilbert S, Groschwitz K, Hogan S, Jurickova I, Trapnell B, Samson C, Gully J.

Gut. 2010 Aug;59(8):1066-78. doi: 10.1136/gut.2009.203893. Epub 2010 Jun 28.

6.

MLCK-dependent exchange and actin binding region-dependent anchoring of ZO-1 regulate tight junction barrier function.

Yu D, Marchiando AM, Weber CR, Raleigh DR, Wang Y, Shen L, Turner JR.

Proc Natl Acad Sci U S A. 2010 May 4;107(18):8237-41. doi: 10.1073/pnas.0908869107. Epub 2010 Apr 19.

7.

Caveolin-1-dependent occludin endocytosis is required for TNF-induced tight junction regulation in vivo.

Marchiando AM, Shen L, Graham WV, Weber CR, Schwarz BT, Austin JR 2nd, Raleigh DR, Guan Y, Watson AJ, Montrose MH, Turner JR.

J Cell Biol. 2010 Apr 5;189(1):111-26. doi: 10.1083/jcb.200902153. Epub 2010 Mar 29.

8.

Genetic factors in chronic inflammation: single nucleotide polymorphisms in the STAT-JAK pathway, susceptibility to DNA damage and Crohn's disease in a New Zealand population.

Ferguson LR, Han DY, Fraser AG, Huebner C, Lam WJ, Morgan AR, Duan H, Karunasinghe N.

Mutat Res. 2010 Aug 7;690(1-2):108-15. doi: 10.1016/j.mrfmmm.2010.01.017. Epub 2010 Jan 28.

PMID:
20109474
9.

Epithelial NF-kappaB enhances transmucosal fluid movement by altering tight junction protein composition after T cell activation.

Tang Y, Clayburgh DR, Mittal N, Goretsky T, Dirisina R, Zhang Z, Kron M, Ivancic D, Katzman RB, Grimm G, Lee G, Fryer J, Nusrat A, Turner JR, Barrett TA.

Am J Pathol. 2010 Jan;176(1):158-67. doi: 10.2353/ajpath.2010.090548. Epub 2009 Dec 11.

10.

Intestinal mucosal barrier function in health and disease.

Turner JR.

Nat Rev Immunol. 2009 Nov;9(11):799-809. doi: 10.1038/nri2653. Review.

PMID:
19855405
11.

Epithelial tight junctions in intestinal inflammation.

Schulzke JD, Ploeger S, Amasheh M, Fromm A, Zeissig S, Troeger H, Richter J, Bojarski C, Schumann M, Fromm M.

Ann N Y Acad Sci. 2009 May;1165:294-300. doi: 10.1111/j.1749-6632.2009.04062.x. Review.

PMID:
19538319
12.

Mechanism of cytokine modulation of epithelial tight junction barrier.

Al-Sadi R, Boivin M, Ma T.

Front Biosci (Landmark Ed). 2009 Jan 1;14:2765-78. Review.

13.

Granulocyte-macrophage colony-stimulating factor autoantibodies in murine ileitis and progressive ileal Crohn's disease.

Han X, Uchida K, Jurickova I, Koch D, Willson T, Samson C, Bonkowski E, Trauernicht A, Kim MO, Tomer G, Dubinsky M, Plevy S, Kugathsan S, Trapnell BC, Denson LA.

Gastroenterology. 2009 Apr;136(4):1261-71, e1-3. doi: 10.1053/j.gastro.2008.12.046. Epub 2008 Dec 24.

PMID:
19230854
14.

Targeted epithelial tight junction dysfunction causes immune activation and contributes to development of experimental colitis.

Su L, Shen L, Clayburgh DR, Nalle SC, Sullivan EA, Meddings JB, Abraham C, Turner JR.

Gastroenterology. 2009 Feb;136(2):551-63. doi: 10.1053/j.gastro.2008.10.081. Epub 2008 Nov 6.

15.

Regulation of intestinal barrier function by signal transducer and activator of transcription 5b.

Han X, Ren X, Jurickova I, Groschwitz K, Pasternak BA, Xu H, Wilson TA, Hogan SP, Denson LA.

Gut. 2009 Jan;58(1):49-58. doi: 10.1136/gut.2007.145094. Epub 2008 Aug 7.

16.

ZO-1- and ZO-2-dependent integration of myosin-2 to epithelial zonula adherens.

Yamazaki Y, Umeda K, Wada M, Nada S, Okada M, Tsukita S, Tsukita S.

Mol Biol Cell. 2008 Sep;19(9):3801-11. doi: 10.1091/mbc.E08-04-0352. Epub 2008 Jul 2.

17.

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.

Barrett JC, Hansoul S, Nicolae DL, Cho JH, Duerr RH, Rioux JD, Brant SR, Silverberg MS, Taylor KD, Barmada MM, Bitton A, Dassopoulos T, Datta LW, Green T, Griffiths AM, Kistner EO, Murtha MT, Regueiro MD, Rotter JI, Schumm LP, Steinhart AH, Targan SR, Xavier RJ; NIDDK IBD Genetics Consortium, Libioulle C, Sandor C, Lathrop M, Belaiche J, Dewit O, Gut I, Heath S, Laukens D, Mni M, Rutgeerts P, Van Gossum A, Zelenika D, Franchimont D, Hugot JP, de Vos M, Vermeire S, Louis E; Belgian-French IBD Consortium; Wellcome Trust Case Control Consortium, Cardon LR, Anderson CA, Drummond H, Nimmo E, Ahmad T, Prescott NJ, Onnie CM, Fisher SA, Marchini J, Ghori J, Bumpstead S, Gwilliam R, Tremelling M, Deloukas P, Mansfield J, Jewell D, Satsangi J, Mathew CG, Parkes M, Georges M, Daly MJ.

Nat Genet. 2008 Aug;40(8):955-62. doi: 10.1038/ng.175. Epub 2008 Jun 29.

18.

Interpretation of cytokine signaling through the transcription factors STAT5A and STAT5B.

Hennighausen L, Robinson GW.

Genes Dev. 2008 Mar 15;22(6):711-21. doi: 10.1101/gad.1643908. Review.

19.

Loss of epithelial RelA results in deregulated intestinal proliferative/apoptotic homeostasis and susceptibility to inflammation.

Steinbrecher KA, Harmel-Laws E, Sitcheran R, Baldwin AS.

J Immunol. 2008 Feb 15;180(4):2588-99.

20.

Early embryonic lethality of mice lacking ZO-2, but Not ZO-3, reveals critical and nonredundant roles for individual zonula occludens proteins in mammalian development.

Xu J, Kausalya PJ, Phua DC, Ali SM, Hossain Z, Hunziker W.

Mol Cell Biol. 2008 Mar;28(5):1669-78. doi: 10.1128/MCB.00891-07. Epub 2008 Jan 2.

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