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Items: 1 to 20 of 22

1.

Small-molecule inhibitors of the Wnt pathway potently promote cardiomyocytes from human embryonic stem cell-derived mesoderm.

Willems E, Spiering S, Davidovics H, Lanier M, Xia Z, Dawson M, Cashman J, Mercola M.

Circ Res. 2011 Aug 5;109(4):360-4. doi: 10.1161/CIRCRESAHA.111.249540. Epub 2011 Jul 7.

2.

A chemical biology approach to myocardial regeneration.

Willems E, Lanier M, Forte E, Lo F, Cashman J, Mercola M.

J Cardiovasc Transl Res. 2011 Jun;4(3):340-50. doi: 10.1007/s12265-011-9270-6. Epub 2011 Mar 22. Review.

3.

An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway.

Gonsalves FC, Klein K, Carson BB, Katz S, Ekas LA, Evans S, Nagourney R, Cardozo T, Brown AM, DasGupta R.

Proc Natl Acad Sci U S A. 2011 Apr 12;108(15):5954-63. doi: 10.1073/pnas.1017496108. Epub 2011 Mar 10.

4.

Cardiac muscle regeneration: lessons from development.

Mercola M, Ruiz-Lozano P, Schneider MD.

Genes Dev. 2011 Feb 15;25(4):299-309. doi: 10.1101/gad.2018411. Review.

5.

Stage-specific optimization of activin/nodal and BMP signaling promotes cardiac differentiation of mouse and human pluripotent stem cell lines.

Kattman SJ, Witty AD, Gagliardi M, Dubois NC, Niapour M, Hotta A, Ellis J, Keller G.

Cell Stem Cell. 2011 Feb 4;8(2):228-40. doi: 10.1016/j.stem.2010.12.008.

6.

Cardiopoietic factors: extracellular signals for cardiac lineage commitment.

Noseda M, Peterkin T, Simões FC, Patient R, Schneider MD.

Circ Res. 2011 Jan 7;108(1):129-52. doi: 10.1161/CIRCRESAHA.110.223792.

7.

Pyrvinium, a potent small molecule Wnt inhibitor, promotes wound repair and post-MI cardiac remodeling.

Saraswati S, Alfaro MP, Thorne CA, Atkinson J, Lee E, Young PP.

PLoS One. 2010 Nov 29;5(11):e15521. doi: 10.1371/journal.pone.0015521.

8.

Cardiac induction of embryonic stem cells by a small molecule inhibitor of Wnt/β-catenin signaling.

Wang H, Hao J, Hong CC.

ACS Chem Biol. 2011 Feb 18;6(2):192-7. doi: 10.1021/cb100323z. Epub 2010 Nov 24.

9.

Impacts of recent advances in cardiovascular regenerative medicine on clinical therapies and drug discovery.

Murata M, Tohyama S, Fukuda K.

Pharmacol Ther. 2010 May;126(2):109-18. doi: 10.1016/j.pharmthera.2010.01.010. Epub 2010 Feb 13. Review.

PMID:
20156482
10.

The importance of Wnt signaling in cardiovascular development.

Tian Y, Cohen ED, Morrisey EE.

Pediatr Cardiol. 2010 Apr;31(3):342-8. doi: 10.1007/s00246-009-9606-z. Epub 2009 Dec 5. Review.

11.

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling.

Huang SM, Mishina YM, Liu S, Cheung A, Stegmeier F, Michaud GA, Charlat O, Wiellette E, Zhang Y, Wiessner S, Hild M, Shi X, Wilson CJ, Mickanin C, Myer V, Fazal A, Tomlinson R, Serluca F, Shao W, Cheng H, Shultz M, Rau C, Schirle M, Schlegl J, Ghidelli S, Fawell S, Lu C, Curtis D, Kirschner MW, Lengauer C, Finan PM, Tallarico JA, Bouwmeester T, Porter JA, Bauer A, Cong F.

Nature. 2009 Oct 1;461(7264):614-20. doi: 10.1038/nature08356. Epub 2009 Sep 16.

PMID:
19759537
12.

Structure-activity relationship studies of small-molecule inhibitors of Wnt response.

Lu J, Ma Z, Hsieh JC, Fan CW, Chen B, Longgood JC, Williams NS, Amatruda JF, Lum L, Chen C.

Bioorg Med Chem Lett. 2009 Jul 15;19(14):3825-7. doi: 10.1016/j.bmcl.2009.04.040. Epub 2009 Apr 18.

13.

Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.

Chen B, Dodge ME, Tang W, Lu J, Ma Z, Fan CW, Wei S, Hao W, Kilgore J, Williams NS, Roth MG, Amatruda JF, Chen C, Lum L.

Nat Chem Biol. 2009 Feb;5(2):100-7. doi: 10.1038/nchembio.137. Epub 2009 Jan 4.

14.

Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population.

Yang L, Soonpaa MH, Adler ED, Roepke TK, Kattman SJ, Kennedy M, Henckaerts E, Bonham K, Abbott GW, Linden RM, Field LJ, Keller GM.

Nature. 2008 May 22;453(7194):524-8. doi: 10.1038/nature06894. Epub 2008 Apr 23.

PMID:
18432194
15.

Involvement of TGF-beta1 signaling in cardiomyocyte differentiation from P19CL6 cells.

Lim JY, Kim WH, Kim J, Park SI.

Mol Cells. 2007 Dec 31;24(3):431-6.

16.

The application of human embryonic stem cell technologies to drug discovery.

Sartipy P, Björquist P, Strehl R, Hyllner J.

Drug Discov Today. 2007 Sep;12(17-18):688-99. Epub 2007 Aug 30. Review.

PMID:
17826681
17.

Wnt/beta-catenin signaling pathway as a novel cancer drug target.

Luu HH, Zhang R, Haydon RC, Rayburn E, Kang Q, Si W, Park JK, Wang H, Peng Y, Jiang W, He TC.

Curr Cancer Drug Targets. 2004 Dec;4(8):653-71. Review.

PMID:
15578921
18.

Transcriptional regulation by Smads: crosstalk between the TGF-beta and Wnt pathways.

Letamendia A, Labbé E, Attisano L.

J Bone Joint Surg Am. 2001;83-A Suppl 1(Pt 1):S31-9. Review.

PMID:
11263663
19.

Inhibition of Wnt activity induces heart formation from posterior mesoderm.

Marvin MJ, Di Rocco G, Gardiner A, Bush SM, Lassar AB.

Genes Dev. 2001 Feb 1;15(3):316-27.

20.

Wnt antagonism initiates cardiogenesis in Xenopus laevis.

Schneider VA, Mercola M.

Genes Dev. 2001 Feb 1;15(3):304-15.

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