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Apoptosis in skeletal myocytes: a potential target for interventions against sarcopenia and physical frailty - a mini-review.

Marzetti E, Calvani R, Bernabei R, Leeuwenburgh C.

Gerontology. 2012;58(2):99-106. doi: 10.1159/000330064. Epub 2011 Sep 23. Review.


Current and future pharmacologic treatment of sarcopenia.

Rolland Y, Onder G, Morley JE, Gillette-Guyonet S, Abellan van Kan G, Vellas B.

Clin Geriatr Med. 2011 Aug;27(3):423-47. doi: 10.1016/j.cger.2011.03.008. Epub 2011 May 14. Review.


Ryanodine receptor oxidation causes intracellular calcium leak and muscle weakness in aging.

Andersson DC, Betzenhauser MJ, Reiken S, Meli AC, Umanskaya A, Xie W, Shiomi T, Zalk R, Lacampagne A, Marks AR.

Cell Metab. 2011 Aug 3;14(2):196-207. doi: 10.1016/j.cmet.2011.05.014.


Aging impairs contraction-induced human skeletal muscle mTORC1 signaling and protein synthesis.

Fry CS, Drummond MJ, Glynn EL, Dickinson JM, Gundermann DM, Timmerman KL, Walker DK, Dhanani S, Volpi E, Rasmussen BB.

Skelet Muscle. 2011 Mar 2;1(1):11. doi: 10.1186/2044-5040-1-11.


Angiotensin II, oxidative stress and skeletal muscle wasting.

Sukhanov S, Semprun-Prieto L, Yoshida T, Michael Tabony A, Higashi Y, Galvez S, Delafontaine P.

Am J Med Sci. 2011 Aug;342(2):143-7. doi: 10.1097/MAJ.0b013e318222e620. Review.


Aging biology and novel targets for drug discovery.

Le Couteur DG, McLachlan AJ, Quinn RJ, Simpson SJ, de Cabo R.

J Gerontol A Biol Sci Med Sci. 2012 Feb;67(2):168-74. doi: 10.1093/gerona/glr095. Epub 2011 Jun 21. Review.


Losartan restores skeletal muscle remodeling and protects against disuse atrophy in sarcopenia.

Burks TN, Andres-Mateos E, Marx R, Mejias R, Van Erp C, Simmers JL, Walston JD, Ward CW, Cohn RD.

Sci Transl Med. 2011 May 11;3(82):82ra37. doi: 10.1126/scitranslmed.3002227.


PKB signaling and atrogene expression in skeletal muscle of aged mice.

Gaugler M, Brown A, Merrell E, DiSanto-Rose M, Rathmacher JA, Reynolds TH 4th.

J Appl Physiol (1985). 2011 Jul;111(1):192-9. doi: 10.1152/japplphysiol.00175.2011. Epub 2011 May 5.


Spatial coupling of mTOR and autophagy augments secretory phenotypes.

Narita M, Young AR, Arakawa S, Samarajiwa SA, Nakashima T, Yoshida S, Hong S, Berry LS, Reichelt S, Ferreira M, Tavaré S, Inoki K, Shimizu S, Narita M.

Science. 2011 May 20;332(6032):966-70. doi: 10.1126/science.1205407. Epub 2011 Apr 21.


Long-term supplementation with resveratrol alleviates oxidative stress but does not attenuate sarcopenia in aged mice.

Jackson JR, Ryan MJ, Alway SE.

J Gerontol A Biol Sci Med Sci. 2011 Jul;66(7):751-64. doi: 10.1093/gerona/glr047. Epub 2011 Mar 31.


Resveratrol in cardiovascular health and disease.

Petrovski G, Gurusamy N, Das DK.

Ann N Y Acad Sci. 2011 Jan;1215:22-33. doi: 10.1111/j.1749-6632.2010.05843.x. Review.


Differential effects of enalapril and losartan on body composition and indices of muscle quality in aged male Fischer 344 × Brown Norway rats.

Carter CS, Giovannini S, Seo DO, DuPree J, Morgan D, Chung HY, Lees H, Daniels M, Hubbard GB, Lee S, Ikeno Y, Foster TC, Buford TW, Marzetti E.

Age (Dordr). 2011 Jun;33(2):167-83. doi: 10.1007/s11357-010-9196-y. Epub 2010 Dec 14. Erratum in: Age (Dordr). 2011 Jun;33(2):185. Giovaninni, Silvia [corrected to Giovannini, Silvia].


TOR and ageing: a complex pathway for a complex process.

McCormick MA, Tsai SY, Kennedy BK.

Philos Trans R Soc Lond B Biol Sci. 2011 Jan 12;366(1561):17-27. doi: 10.1098/rstb.2010.0198. Review.


Mechanisms regulating muscle mass during disuse atrophy and rehabilitation in humans.

Marimuthu K, Murton AJ, Greenhaff PL.

J Appl Physiol (1985). 2011 Feb;110(2):555-60. doi: 10.1152/japplphysiol.00962.2010. Epub 2010 Oct 28. Review.


Mammalian target of rapamycin complex 1 is involved in differentiation of regenerating myofibers in vivo.

Miyabara EH, Conte TC, Silva MT, Baptista IL, Bueno C Jr, Fiamoncini J, Lambertucci RH, Serra CS, Brum PC, Pithon-Curi T, Curi R, Aoki MS, Oliveira AC, Moriscot AS.

Muscle Nerve. 2010 Nov;42(5):778-87. doi: 10.1002/mus.21754.


Muscle wasting in aged, sarcopenic rats is associated with enhanced activity of the ubiquitin proteasome pathway.

Altun M, Besche HC, Overkleeft HS, Piccirillo R, Edelmann MJ, Kessler BM, Goldberg AL, Ulfhake B.

J Biol Chem. 2010 Dec 17;285(51):39597-608. doi: 10.1074/jbc.M110.129718. Epub 2010 Oct 12.


Caloric restriction delays aging-induced cellular phenotypes in rhesus monkey skeletal muscle.

McKiernan SH, Colman RJ, Lopez M, Beasley TM, Aiken JM, Anderson RM, Weindruch R.

Exp Gerontol. 2011 Jan;46(1):23-9. doi: 10.1016/j.exger.2010.09.011. Epub 2010 Sep 29.


Mediation of endogenous antioxidant enzymes and apoptotic signaling by resveratrol following muscle disuse in the gastrocnemius muscles of young and old rats.

Jackson JR, Ryan MJ, Hao Y, Alway SE.

Am J Physiol Regul Integr Comp Physiol. 2010 Dec;299(6):R1572-81. doi: 10.1152/ajpregu.00489.2010. Epub 2010 Sep 22.


Life span extension by resveratrol, rapamycin, and metformin: The promise of dietary restriction mimetics for an healthy aging.

Mouchiroud L, Molin L, Dallière N, Solari F.

Biofactors. 2010 Sep-Oct;36(5):377-82. doi: 10.1002/biof.127. Review.


Sarcopenia: prevalence, mechanisms, and functional consequences.

Berger MJ, Doherty TJ.

Interdiscip Top Gerontol. 2010;37:94-114. doi: 10.1159/000319997. Epub 2010 Aug 10. Review.


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