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Peroxisome proliferator activator receptor gamma coactivator-1alpha (PGC-1α) improves motor performance and survival in a mouse model of amyotrophic lateral sclerosis.

Zhao W, Varghese M, Yemul S, Pan Y, Cheng A, Marano P, Hassan S, Vempati P, Chen F, Qian X, Pasinetti GM.

Mol Neurodegener. 2011 Jul 19;6(1):51. doi: 10.1186/1750-1326-6-51.


PGC-1α, a potential therapeutic target for early intervention in Parkinson's disease.

Zheng B, Liao Z, Locascio JJ, Lesniak KA, Roderick SS, Watt ML, Eklund AC, Zhang-James Y, Kim PD, Hauser MA, Grünblatt E, Moran LB, Mandel SA, Riederer P, Miller RM, Federoff HJ, Wüllner U, Papapetropoulos S, Youdim MB, Cantuti-Castelvetri I, Young AB, Vance JM, Davis RL, Hedreen JC, Adler CH, Beach TG, Graeber MB, Middleton FA, Rochet JC, Scherzer CR; Global PD Gene Expression (GPEX) Consortium.

Sci Transl Med. 2010 Oct 6;2(52):52ra73. doi: 10.1126/scitranslmed.3001059.


A novel pathway regulates memory and plasticity via SIRT1 and miR-134.

Gao J, Wang WY, Mao YW, Gräff J, Guan JS, Pan L, Mak G, Kim D, Su SC, Tsai LH.

Nature. 2010 Aug 26;466(7310):1105-9. doi: 10.1038/nature09271. Epub 2010 Jul 11.


Neuronal SIRT1 regulates endocrine and behavioral responses to calorie restriction.

Cohen DE, Supinski AM, Bonkowski MS, Donmez G, Guarente LP.

Genes Dev. 2009 Dec 15;23(24):2812-7. doi: 10.1101/gad.1839209. Erratum in: Genes Dev. 2010 Mar 1;24(5):516.


The role of Sirt1: at the crossroad between promotion of longevity and protection against Alzheimer's disease neuropathology.

Wang J, Fivecoat H, Ho L, Pan Y, Ling E, Pasinetti GM.

Biochim Biophys Acta. 2010 Aug;1804(8):1690-4. doi: 10.1016/j.bbapap.2009.11.015. Epub 2009 Nov 26. Review.


PrimerBank: a resource of human and mouse PCR primer pairs for gene expression detection and quantification.

Spandidos A, Wang X, Wang H, Seed B.

Nucleic Acids Res. 2010 Jan;38(Database issue):D792-9. doi: 10.1093/nar/gkp1005. Epub 2009 Nov 11.


New insights in the biology of BDNF synthesis and release: implications in CNS function.

Greenberg ME, Xu B, Lu B, Hempstead BL.

J Neurosci. 2009 Oct 14;29(41):12764-7. doi: 10.1523/JNEUROSCI.3566-09.2009. Review.


Acetylation targets mutant huntingtin to autophagosomes for degradation.

Jeong H, Then F, Melia TJ Jr, Mazzulli JR, Cui L, Savas JN, Voisine C, Paganetti P, Tanese N, Hart AC, Yamamoto A, Krainc D.

Cell. 2009 Apr 3;137(1):60-72. doi: 10.1016/j.cell.2009.03.018.


TORC1 regulates activity-dependent CREB-target gene transcription and dendritic growth of developing cortical neurons.

Li S, Zhang C, Takemori H, Zhou Y, Xiong ZQ.

J Neurosci. 2009 Feb 25;29(8):2334-43. doi: 10.1523/JNEUROSCI.2296-08.2009.


The insulin paradox: aging, proteotoxicity and neurodegeneration.

Cohen E, Dillin A.

Nat Rev Neurosci. 2008 Oct;9(10):759-67. doi: 10.1038/nrn2474. Epub 2008 Sep 4. Review.


Inhibition of specific HDACs and sirtuins suppresses pathogenesis in a Drosophila model of Huntington's disease.

Pallos J, Bodai L, Lukacsovich T, Purcell JM, Steffan JS, Thompson LM, Marsh JL.

Hum Mol Genet. 2008 Dec 1;17(23):3767-75. doi: 10.1093/hmg/ddn273. Epub 2008 Sep 1.


The Creb1 coactivator Crtc1 is required for energy balance and fertility.

Altarejos JY, Goebel N, Conkright MD, Inoue H, Xie J, Arias CM, Sawchenko PE, Montminy M.

Nat Med. 2008 Oct;14(10):1112-7. doi: 10.1038/nm.1866. Epub 2008 Aug 31.


Mitochondria and neurodegeneration.

Beal MF.

Novartis Found Symp. 2007;287:183-92; discussion 192-6. Review.


SIRT1 transgenic mice show phenotypes resembling calorie restriction.

Bordone L, Cohen D, Robinson A, Motta MC, van Veen E, Czopik A, Steele AD, Crowe H, Marmor S, Luo J, Gu W, Guarente L.

Aging Cell. 2007 Dec;6(6):759-67. Epub 2007 Sep 17.


Production and purification of lentiviral vectors.

Tiscornia G, Singer O, Verma IM.

Nat Protoc. 2006;1(1):241-5.


Mammalian sirtuins--emerging roles in physiology, aging, and calorie restriction.

Haigis MC, Guarente LP.

Genes Dev. 2006 Nov 1;20(21):2913-21. Review.


Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1alpha in Huntington's disease neurodegeneration.

Weydt P, Pineda VV, Torrence AE, Libby RT, Satterfield TF, Lazarowski ER, Gilbert ML, Morton GJ, Bammler TK, Strand AD, Cui L, Beyer RP, Easley CN, Smith AC, Krainc D, Luquet S, Sweet IR, Schwartz MW, La Spada AR.

Cell Metab. 2006 Nov;4(5):349-62. Epub 2006 Oct 19.


Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration.

Cui L, Jeong H, Borovecki F, Parkhurst CN, Tanese N, Krainc D.

Cell. 2006 Oct 6;127(1):59-69.


Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1alpha transcription and mitochondrial biogenesis in muscle cells.

Wu Z, Huang X, Feng Y, Handschin C, Feng Y, Gullicksen PS, Bare O, Labow M, Spiegelman B, Stevenson SC.

Proc Natl Acad Sci U S A. 2006 Sep 26;103(39):14379-84. Epub 2006 Sep 15.


Neurotrophin signalling in health and disease.

Chao MV, Rajagopal R, Lee FS.

Clin Sci (Lond). 2006 Feb;110(2):167-73. Review.


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