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Items: 1 to 20 of 34


The dual effect of Rac2 on phospholipase D2 regulation that explains both the onset and termination of chemotaxis.

Peng HJ, Henkels KM, Mahankali M, Marchal C, Bubulya P, Dinauer MC, Gomez-Cambronero J.

Mol Cell Biol. 2011 Jun;31(11):2227-40. doi: 10.1128/MCB.01348-10. Epub 2011 Mar 28.


Evidence for two CRIB domains in phospholipase D2 (PLD2) that the enzyme uses to specifically bind to the small GTPase Rac2.

Peng HJ, Henkels KM, Mahankali M, Dinauer MC, Gomez-Cambronero J.

J Biol Chem. 2011 May 6;286(18):16308-20. doi: 10.1074/jbc.M110.206672. Epub 2011 Mar 4.


Large Arf1 guanine nucleotide exchange factors: evolution, domain structure, and roles in membrane trafficking and human disease.

Bui QT, Golinelli-Cohen MP, Jackson CL.

Mol Genet Genomics. 2009 Oct;282(4):329-50. doi: 10.1007/s00438-009-0473-3. Epub 2009 Aug 11. Review.


Phosphatidic acid signaling regulation of Ras superfamily of small guanosine triphosphatases.

Zhang Y, Du G.

Biochim Biophys Acta. 2009 Sep;1791(9):850-5. doi: 10.1016/j.bbalip.2009.05.013. Epub 2009 Jun 21. Review.


Sequential regulation of DOCK2 dynamics by two phospholipids during neutrophil chemotaxis.

Nishikimi A, Fukuhara H, Su W, Hongu T, Takasuga S, Mihara H, Cao Q, Sanematsu F, Kanai M, Hasegawa H, Tanaka Y, Shibasaki M, Kanaho Y, Sasaki T, Frohman MA, Fukui Y.

Science. 2009 Apr 17;324(5925):384-7. doi: 10.1126/science.1170179. Epub 2009 Mar 26.


Large ARF guanine nucleotide exchange factors in membrane trafficking.

Anders N, Jürgens G.

Cell Mol Life Sci. 2008 Nov;65(21):3433-45. doi: 10.1007/s00018-008-8227-7.


Activated ezrin promotes cell migration through recruitment of the GEF Dbl to lipid rafts and preferential downstream activation of Cdc42.

Prag S, Parsons M, Keppler MD, Ameer-Beg SM, Barber P, Hunt J, Beavil AJ, Calvert R, Arpin M, Vojnovic B, Ng T.

Mol Biol Cell. 2007 Aug;18(8):2935-48. Epub 2007 May 30.


Phospholipase D2-generated phosphatidic acid couples EGFR stimulation to Ras activation by Sos.

Zhao C, Du G, Skowronek K, Frohman MA, Bar-Sagi D.

Nat Cell Biol. 2007 Jun;9(6):706-12. Epub 2007 May 7.


The Rac effector p67phox regulates phagocyte NADPH oxidase by stimulating Vav1 guanine nucleotide exchange activity.

Ming W, Li S, Billadeau DD, Quilliam LA, Dinauer MC.

Mol Cell Biol. 2007 Jan;27(1):312-23. Epub 2006 Oct 23.


Regulation of the phagocyte NADPH oxidase by Rac GTPase.

Bokoch GM, Zhao T.

Antioxid Redox Signal. 2006 Sep-Oct;8(9-10):1533-48. Review.


The phosphoinositide-binding protein p40phox activates the NADPH oxidase during FcgammaIIA receptor-induced phagocytosis.

Suh CI, Stull ND, Li XJ, Tian W, Price MO, Grinstein S, Yaffe MB, Atkinson S, Dinauer MC.

J Exp Med. 2006 Aug 7;203(8):1915-25. Epub 2006 Jul 31.


Phagocyte cell migration is mediated by phospholipases PLD1 and PLD2.

Lehman N, Di Fulvio M, McCray N, Campos I, Tabatabaian F, Gomez-Cambronero J.

Blood. 2006 Nov 15;108(10):3564-72. Epub 2006 Jul 27.


Rac1 links leading edge and uropod events through Rho and myosin activation during chemotaxis.

Pestonjamasp KN, Forster C, Sun C, Gardiner EM, Bohl B, Weiner O, Bokoch GM, Glogauer M.

Blood. 2006 Oct 15;108(8):2814-20. Epub 2006 Jun 29.


Phospholipase D couples survival and migration signals in stress response of human cancer cells.

Zheng Y, Rodrik V, Toschi A, Shi M, Hui L, Shen Y, Foster DA.

J Biol Chem. 2006 Jun 9;281(23):15862-8. Epub 2006 Apr 4.


In vitro guanine nucleotide exchange activity of DHR-2/DOCKER/CZH2 domains.

Côté JF, Vuori K.

Methods Enzymol. 2006;406:41-57.


The elucidation of novel SH2 binding sites on PLD2.

Di Fulvio M, Lehman N, Lin X, Lopez I, Gomez-Cambronero J.

Oncogene. 2006 May 18;25(21):3032-40.


The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling.

Arnold K, Bordoli L, Kopp J, Schwede T.

Bioinformatics. 2006 Jan 15;22(2):195-201. Epub 2005 Nov 13.


Signaling interplay in Ras superfamily function.

Mitin N, Rossman KL, Der CJ.

Curr Biol. 2005 Jul 26;15(14):R563-74. Review.


GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors.

Rossman KL, Der CJ, Sondek J.

Nat Rev Mol Cell Biol. 2005 Feb;6(2):167-80. Review.


Antagonistic cross-talk between Rac and Cdc42 GTPases regulates generation of reactive oxygen species.

Diebold BA, Fowler B, Lu J, Dinauer MC, Bokoch GM.

J Biol Chem. 2004 Jul 2;279(27):28136-42. Epub 2004 May 3.

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