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Human apoE isoforms differentially regulate brain amyloid-β peptide clearance.

Castellano JM, Kim J, Stewart FR, Jiang H, DeMattos RB, Patterson BW, Fagan AM, Morris JC, Mawuenyega KG, Cruchaga C, Goate AM, Bales KR, Paul SM, Bateman RJ, Holtzman DM.

Sci Transl Med. 2011 Jun 29;3(89):89ra57. doi: 10.1126/scitranslmed.3002156.


Long-term calorie restriction, but not endurance exercise, lowers core body temperature in humans.

Soare A, Cangemi R, Omodei D, Holloszy JO, Fontana L.

Aging (Albany NY). 2011 Apr;3(4):374-9.


Drugs, nutrients, and phytoactive principles improving the health span of rodent models of human age-related diseases.

Lebel M, Picard F, Ferland G, Gaudreau P.

J Gerontol A Biol Sci Med Sci. 2012 Feb;67(2):140-51. doi: 10.1093/gerona/glr038. Epub 2011 Mar 10. Review.


Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans.

Guevara-Aguirre J, Balasubramanian P, Guevara-Aguirre M, Wei M, Madia F, Cheng CW, Hwang D, Martin-Montalvo A, Saavedra J, Ingles S, de Cabo R, Cohen P, Longo VD.

Sci Transl Med. 2011 Feb 16;3(70):70ra13. doi: 10.1126/scitranslmed.3001845.


Glycolytic inhibition as a strategy for developing calorie restriction mimetics.

Ingram DK, Roth GS.

Exp Gerontol. 2011 Feb-Mar;46(2-3):148-54. doi: 10.1016/j.exger.2010.12.001. Epub 2010 Dec 15. Review.


Network medicine: a network-based approach to human disease.

Barabási AL, Gulbahce N, Loscalzo J.

Nat Rev Genet. 2011 Jan;12(1):56-68. doi: 10.1038/nrg2918. Review.


Gender differences in metformin effect on aging, life span and spontaneous tumorigenesis in 129/Sv mice.

Anisimov VN, Piskunova TS, Popovich IG, Zabezhinski MA, Tyndyk ML, Egormin PA, Yurova MV, Rosenfeld SV, Semenchenko AV, Kovalenko IG, Poroshina TE, Berstein LM.

Aging (Albany NY). 2010 Dec;2(12):945-58.


Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomised trials.

Rothwell PM, Fowkes FG, Belch JF, Ogawa H, Warlow CP, Meade TW.

Lancet. 2011 Jan 1;377(9759):31-41. doi: 10.1016/S0140-6736(10)62110-1. Epub 2010 Dec 6.


Drug discovery and development for ageing: opportunities and challenges.

Evans WJ.

Philos Trans R Soc Lond B Biol Sci. 2011 Jan 12;366(1561):113-9. doi: 10.1098/rstb.2010.0287. Review.


Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling.

Kickstein E, Krauss S, Thornhill P, Rutschow D, Zeller R, Sharkey J, Williamson R, Fuchs M, Köhler A, Glossmann H, Schneider R, Sutherland C, Schweiger S.

Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21830-5. doi: 10.1073/pnas.0912793107. Epub 2010 Nov 22.


Nutritional influence on epigenetics and effects on longevity.

Niculescu MD, Lupu DS.

Curr Opin Clin Nutr Metab Care. 2011 Jan;14(1):35-40. doi: 10.1097/MCO.0b013e328340ff7c. Review.


Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer.

Herranz D, Muñoz-Martin M, Cañamero M, Mulero F, Martinez-Pastor B, Fernandez-Capetillo O, Serrano M.

Nat Commun. 2010 Apr 12;1:3. doi: 10.1038/ncomms1001.


Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice.

Miller RA, Harrison DE, Astle CM, Baur JA, Boyd AR, de Cabo R, Fernandez E, Flurkey K, Javors MA, Nelson JF, Orihuela CJ, Pletcher S, Sharp ZD, Sinclair D, Starnes JW, Wilkinson JE, Nadon NL, Strong R.

J Gerontol A Biol Sci Med Sci. 2011 Feb;66(2):191-201. doi: 10.1093/gerona/glq178. Epub 2010 Oct 25.


Caloric restriction and longevity: effects of reduced body temperature.

Carrillo AE, Flouris AD.

Ageing Res Rev. 2011 Jan;10(1):153-62. doi: 10.1016/j.arr.2010.10.001. Epub 2010 Oct 20. Review.


SIRT1 activation by small molecules: kinetic and biophysical evidence for direct interaction of enzyme and activator.

Dai H, Kustigian L, Carney D, Case A, Considine T, Hubbard BP, Perni RB, Riera TV, Szczepankiewicz B, Vlasuk GP, Stein RL.

J Biol Chem. 2010 Oct 22;285(43):32695-703. doi: 10.1074/jbc.M110.133892. Epub 2010 Aug 11.


Extending healthy life span--from yeast to humans.

Fontana L, Partridge L, Longo VD.

Science. 2010 Apr 16;328(5976):321-6. doi: 10.1126/science.1172539. Review.


Insulin-like growth factor-I regulation of immune function: a potential therapeutic target in autoimmune diseases?

Smith TJ.

Pharmacol Rev. 2010 Jun;62(2):199-236. doi: 10.1124/pr.109.002469. Epub 2010 Apr 14. Review.


The genetics of ageing.

Kenyon CJ.

Nature. 2010 Mar 25;464(7288):504-12. doi: 10.1038/nature08980. Review. Erratum in: Nature. 2010 Sep 30;467(7315):622.


Metformin supplementation and life span in Fischer-344 rats.

Smith DL Jr, Elam CF Jr, Mattison JA, Lane MA, Roth GS, Ingram DK, Allison DB.

J Gerontol A Biol Sci Med Sci. 2010 May;65(5):468-74. doi: 10.1093/gerona/glq033. Epub 2010 Mar 19.


Resveratrol, sirtuins, and the promise of a DR mimetic.

Baur JA.

Mech Ageing Dev. 2010 Apr;131(4):261-9. doi: 10.1016/j.mad.2010.02.007. Epub 2010 Feb 26. Review.

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