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Items: 1 to 20 of 89


Dual amyloid domains promote differential functioning of the chaplin proteins during Streptomyces aerial morphogenesis.

Capstick DS, Jomaa A, Hanke C, Ortega J, Elliot MA.

Proc Natl Acad Sci U S A. 2011 Jun 14;108(24):9821-6. doi: 10.1073/pnas.1018715108. Epub 2011 May 31.


Antimicrobial protegrin-1 forms amyloid-like fibrils with rapid kinetics suggesting a functional link.

Jang H, Arce FT, Mustata M, Ramachandran S, Capone R, Nussinov R, Lal R.

Biophys J. 2011 Apr 6;100(7):1775-83. doi: 10.1016/j.bpj.2011.01.072.


β-Barrel topology of Alzheimer's β-amyloid ion channels.

Jang H, Arce FT, Ramachandran S, Capone R, Lal R, Nussinov R.

J Mol Biol. 2010 Dec 17;404(5):917-34. doi: 10.1016/j.jmb.2010.10.025. Epub 2010 Oct 21.


The KATP channel activator diazoxide ameliorates amyloid-β and tau pathologies and improves memory in the 3xTgAD mouse model of Alzheimer's disease.

Liu D, Pitta M, Lee JH, Ray B, Lahiri DK, Furukawa K, Mughal M, Jiang H, Villarreal J, Cutler RG, Greig NH, Mattson MP.

J Alzheimers Dis. 2010;22(2):443-57. doi: 10.3233/JAD-2010-101017.


L-type voltage-gated calcium channel blockade with isradipine as a therapeutic strategy for Alzheimer's disease.

Anekonda TS, Quinn JF, Harris C, Frahler K, Wadsworth TL, Woltjer RL.

Neurobiol Dis. 2011 Jan;41(1):62-70. doi: 10.1016/j.nbd.2010.08.020. Epub 2010 Sep 9.


Amyloid peptide pores and the beta sheet conformation.

Kagan BL, Thundimadathil J.

Adv Exp Med Biol. 2010;677:150-67. Review.


Antimicrobial protegrin-1 forms ion channels: molecular dynamic simulation, atomic force microscopy, and electrical conductance studies.

Capone R, Mustata M, Jang H, Arce FT, Nussinov R, Lal R.

Biophys J. 2010 Jun 2;98(11):2644-52. doi: 10.1016/j.bpj.2010.02.024.


Truncated beta-amyloid peptide channels provide an alternative mechanism for Alzheimer's Disease and Down syndrome.

Jang H, Arce FT, Ramachandran S, Capone R, Azimova R, Kagan BL, Nussinov R, Lal R.

Proc Natl Acad Sci U S A. 2010 Apr 6;107(14):6538-43. doi: 10.1073/pnas.0914251107. Epub 2010 Mar 22.


The Alzheimer's disease-associated amyloid beta-protein is an antimicrobial peptide.

Soscia SJ, Kirby JE, Washicosky KJ, Tucker SM, Ingelsson M, Hyman B, Burton MA, Goldstein LE, Duong S, Tanzi RE, Moir RD.

PLoS One. 2010 Mar 3;5(3):e9505. doi: 10.1371/journal.pone.0009505.


Three-dimensional structure of the anthrax toxin pore inserted into lipid nanodiscs and lipid vesicles.

Katayama H, Wang J, Tama F, Chollet L, Gogol EP, Collier RJ, Fisher MT.

Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3453-7. doi: 10.1073/pnas.1000100107. Epub 2010 Feb 8.


Misfolded amyloid ion channels present mobile beta-sheet subunits in contrast to conventional ion channels.

Jang H, Arce FT, Capone R, Ramachandran S, Lal R, Nussinov R.

Biophys J. 2009 Dec 2;97(11):3029-37. doi: 10.1016/j.bpj.2009.09.014.


K3 fragment of amyloidogenic beta(2)-microglobulin forms ion channels: implication for dialysis related amyloidosis.

Mustata M, Capone R, Jang H, Arce FT, Ramachandran S, Lal R, Nussinov R.

J Am Chem Soc. 2009 Oct 21;131(41):14938-45. doi: 10.1021/ja9049299.


Functional amyloids as natural storage of peptide hormones in pituitary secretory granules.

Maji SK, Perrin MH, Sawaya MR, Jessberger S, Vadodaria K, Rissman RA, Singru PS, Nilsson KP, Simon R, Schubert D, Eisenberg D, Rivier J, Sawchenko P, Vale W, Riek R.

Science. 2009 Jul 17;325(5938):328-32. doi: 10.1126/science.1173155. Epub 2009 Jun 18.


Amyloid-beta-induced ion flux in artificial lipid bilayers and neuronal cells: resolving a controversy.

Capone R, Quiroz FG, Prangkio P, Saluja I, Sauer AM, Bautista MR, Turner RS, Yang J, Mayer M.

Neurotox Res. 2009 Jul;16(1):1-13. doi: 10.1007/s12640-009-9033-1. Epub 2009 Mar 19.


Binding of amphipathic alpha-helical antimicrobial peptides to lipid membranes: lessons from temporins B and L.

Mahalka AK, Kinnunen PK.

Biochim Biophys Acta. 2009 Aug;1788(8):1600-9. doi: 10.1016/j.bbamem.2009.04.012. Epub 2009 Apr 24. Review.


Small molecule blockers of the Alzheimer Abeta calcium channel potently protect neurons from Abeta cytotoxicity.

Diaz JC, Simakova O, Jacobson KA, Arispe N, Pollard HB.

Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3348-53. doi: 10.1073/pnas.0813355106. Epub 2009 Feb 9.


Models of toxic beta-sheet channels of protegrin-1 suggest a common subunit organization motif shared with toxic alzheimer beta-amyloid ion channels.

Jang H, Ma B, Lal R, Nussinov R.

Biophys J. 2008 Nov 15;95(10):4631-42. doi: 10.1529/biophysj.108.134551. Epub 2008 Aug 15.


Amyloidosis of seminal vesicles and ejaculatory ducts: a histologic analysis of 21 cases among 447 prostatectomy specimens.

Kee KH, Lee MJ, Shen SS, Suh JH, Lee OJ, Cho HY, Ayala AG, Ro JY.

Ann Diagn Pathol. 2008 Aug;12(4):235-8. doi: 10.1016/j.anndiagpath.2007.12.004. Epub 2008 Apr 18.


The molecular basis of functional bacterial amyloid polymerization and nucleation.

Wang X, Hammer ND, Chapman MR.

J Biol Chem. 2008 Aug 1;283(31):21530-9. doi: 10.1074/jbc.M800466200. Epub 2008 May 27.


Helical alpha-synuclein forms highly conductive ion channels.

Zakharov SD, Hulleman JD, Dutseva EA, Antonenko YN, Rochet JC, Cramer WA.

Biochemistry. 2007 Dec 18;46(50):14369-79. Epub 2007 Nov 22.


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