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Hallmarks of cancer: the next generation.

Hanahan D, Weinberg RA.

Cell. 2011 Mar 4;144(5):646-74. doi: 10.1016/j.cell.2011.02.013. Review.


BID, BIM, and PUMA are essential for activation of the BAX- and BAK-dependent cell death program.

Ren D, Tu HC, Kim H, Wang GX, Bean GR, Takeuchi O, Jeffers JR, Zambetti GP, Hsieh JJ, Cheng EH.

Science. 2010 Dec 3;330(6009):1390-3. doi: 10.1126/science.1190217.


Pore-forming activity of BAD is regulated by specific phosphorylation and structural transitions of the C-terminal part.

Polzien L, Baljuls A, Roth HM, Kuper J, Benz R, Schweimer K, Hekman M, Rapp UR.

Biochim Biophys Acta. 2011 Feb;1810(2):162-9. doi: 10.1016/j.bbagen.2010.11.002. Epub 2010 Nov 24.


Bax forms an oligomer via separate, yet interdependent, surfaces.

Zhang Z, Zhu W, Lapolla SM, Miao Y, Shao Y, Falcone M, Boreham D, McFarlane N, Ding J, Johnson AE, Zhang XC, Andrews DW, Lin J.

J Biol Chem. 2010 Jun 4;285(23):17614-27. doi: 10.1074/jbc.M110.113456. Epub 2010 Apr 9.


The BCL-2 family reunion.

Chipuk JE, Moldoveanu T, Llambi F, Parsons MJ, Green DR.

Mol Cell. 2010 Feb 12;37(3):299-310. doi: 10.1016/j.molcel.2010.01.025. Review.


Stepwise activation of BAX and BAK by tBID, BIM, and PUMA initiates mitochondrial apoptosis.

Kim H, Tu HC, Ren D, Takeuchi O, Jeffers JR, Zambetti GP, Hsieh JJ, Cheng EH.

Mol Cell. 2009 Nov 13;36(3):487-99. doi: 10.1016/j.molcel.2009.09.030.


Oligomerization of membrane-bound Bcl-2 is involved in its pore formation induced by tBid.

Peng J, Ding J, Tan C, Baggenstoss B, Zhang Z, Lapolla SM, Lin J.

Apoptosis. 2009 Oct;14(10):1145-53. doi: 10.1007/s10495-009-0389-8.


The role of BH3-only protein Bim extends beyond inhibiting Bcl-2-like prosurvival proteins.

Mérino D, Giam M, Hughes PD, Siggs OM, Heger K, O'Reilly LA, Adams JM, Strasser A, Lee EF, Fairlie WD, Bouillet P.

J Cell Biol. 2009 Aug 10;186(3):355-62. doi: 10.1083/jcb.200905153. Epub 2009 Aug 3.


SnapShot: BCL-2 proteins.

Hardwick JM, Youle RJ.

Cell. 2009 Jul 23;138(2):404, 404.e1. doi: 10.1016/j.cell.2009.07.003. No abstract available.


Membrane binding by tBid initiates an ordered series of events culminating in membrane permeabilization by Bax.

Lovell JF, Billen LP, Bindner S, Shamas-Din A, Fradin C, Leber B, Andrews DW.

Cell. 2008 Dec 12;135(6):1074-84. doi: 10.1016/j.cell.2008.11.010.


Bcl-2 family proteins and cancer.

Yip KW, Reed JC.

Oncogene. 2008 Oct 27;27(50):6398-406. doi: 10.1038/onc.2008.307. Review.


BAX activation is initiated at a novel interaction site.

Gavathiotis E, Suzuki M, Davis ML, Pitter K, Bird GH, Katz SG, Tu HC, Kim H, Cheng EH, Tjandra N, Walensky LD.

Nature. 2008 Oct 23;455(7216):1076-81. doi: 10.1038/nature07396.


A short Nur77-derived peptide converts Bcl-2 from a protector to a killer.

Kolluri SK, Zhu X, Zhou X, Lin B, Chen Y, Sun K, Tian X, Town J, Cao X, Lin F, Zhai D, Kitada S, Luciano F, O'Donnell E, Cao Y, He F, Lin J, Reed JC, Satterthwait AC, Zhang XK.

Cancer Cell. 2008 Oct 7;14(4):285-98. doi: 10.1016/j.ccr.2008.09.002.


Bcl-XL inhibits membrane permeabilization by competing with Bax.

Billen LP, Kokoski CL, Lovell JF, Leber B, Andrews DW.

PLoS Biol. 2008 Jun 10;6(6):e147. doi: 10.1371/journal.pbio.0060147.


To trigger apoptosis, Bak exposes its BH3 domain and homodimerizes via BH3:groove interactions.

Dewson G, Kratina T, Sim HW, Puthalakath H, Adams JM, Colman PM, Kluck RM.

Mol Cell. 2008 May 9;30(3):369-80. doi: 10.1016/j.molcel.2008.04.005.


Diagnosing and exploiting cancer's addiction to blocks in apoptosis.

Letai AG.

Nat Rev Cancer. 2008 Feb;8(2):121-32. doi: 10.1038/nrc2297. Review.


The BCL-2 protein family: opposing activities that mediate cell death.

Youle RJ, Strasser A.

Nat Rev Mol Cell Biol. 2008 Jan;9(1):47-59. Review.


BimS-induced apoptosis requires mitochondrial localization but not interaction with anti-apoptotic Bcl-2 proteins.

Weber A, Paschen SA, Heger K, Wilfling F, Frankenberg T, Bauerschmitt H, Seiffert BM, Kirschnek S, Wagner H, Häcker G.

J Cell Biol. 2007 May 21;177(4):625-36.


Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak.

Willis SN, Fletcher JI, Kaufmann T, van Delft MF, Chen L, Czabotar PE, Ierino H, Lee EF, Fairlie WD, Bouillet P, Strasser A, Kluck RM, Adams JM, Huang DC.

Science. 2007 Feb 9;315(5813):856-9.

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