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Items: 1 to 20 of 49

1.

The kinase IKKα inhibits activation of the transcription factor NF-κB by phosphorylating the regulatory molecule TAX1BP1.

Shembade N, Pujari R, Harhaj NS, Abbott DW, Harhaj EW.

Nat Immunol. 2011 Jul 17;12(9):834-43. doi: 10.1038/ni.2066.

2.

Noncanonical K27-linked polyubiquitination of TIEG1 regulates Foxp3 expression and tumor growth.

Peng DJ, Zeng M, Muromoto R, Matsuda T, Shimoda K, Subramaniam M, Spelsberg TC, Wei WZ, Venuprasad K.

J Immunol. 2011 May 15;186(10):5638-47. doi: 10.4049/jimmunol.1003801. Epub 2011 Apr 6.

3.

Ubiquitin makes its mark on immune regulation.

Malynn BA, Ma A.

Immunity. 2010 Dec 14;33(6):843-52. doi: 10.1016/j.immuni.2010.12.007. Review.

4.

Deubiquitinases in the regulation of NF-κB signaling.

Harhaj EW, Dixit VM.

Cell Res. 2011 Jan;21(1):22-39. doi: 10.1038/cr.2010.166. Epub 2010 Nov 30. Review.

5.

Cbl-b and itch: key regulators of peripheral T-cell tolerance.

Venuprasad K.

Cancer Res. 2010 Apr 15;70(8):3009-12. doi: 10.1158/0008-5472.CAN-09-4076. Review.

6.

Macrophage diversity enhances tumor progression and metastasis.

Qian BZ, Pollard JW.

Cell. 2010 Apr 2;141(1):39-51. doi: 10.1016/j.cell.2010.03.014. Review.

7.

Ubiquitin chain cleavage: CYLD at work.

Massoumi R.

Trends Biochem Sci. 2010 Jul;35(7):392-9. doi: 10.1016/j.tibs.2010.02.007. Epub 2010 Mar 26. Review.

PMID:
20347313
8.

Immunity, inflammation, and cancer.

Grivennikov SI, Greten FR, Karin M.

Cell. 2010 Mar 19;140(6):883-99. doi: 10.1016/j.cell.2010.01.025. Review.

9.

Tobacco smoke promotes lung tumorigenesis by triggering IKKbeta- and JNK1-dependent inflammation.

Takahashi H, Ogata H, Nishigaki R, Broide DH, Karin M.

Cancer Cell. 2010 Jan 19;17(1):89-97. doi: 10.1016/j.ccr.2009.12.008.

10.

Lysine 63-linked polyubiquitination of TAK1 at lysine 158 is required for tumor necrosis factor alpha- and interleukin-1beta-induced IKK/NF-kappaB and JNK/AP-1 activation.

Fan Y, Yu Y, Shi Y, Sun W, Xie M, Ge N, Mao R, Chang A, Xu G, Schneider MD, Zhang H, Fu S, Qin J, Yang J.

J Biol Chem. 2010 Feb 19;285(8):5347-60. doi: 10.1074/jbc.M109.076976. Epub 2009 Dec 28.

11.
12.

Immunotherapy in non-small-cell lung carcinoma: from inflammation to vaccination.

Van den Heuvel MM, Burgers SA, van Zandwijk N.

Clin Lung Cancer. 2009 Mar;10(2):99-105. doi: 10.3816/CLC.2009.n.012. Review.

PMID:
19362952
13.

Ubiquitylation in innate and adaptive immunity.

Bhoj VG, Chen ZJ.

Nature. 2009 Mar 26;458(7237):430-7. doi: 10.1038/nature07959. Review.

PMID:
19325622
14.

Bortezomib plus gemcitabine/carboplatin as first-line treatment of advanced non-small cell lung cancer: a phase II Southwest Oncology Group Study (S0339).

Davies AM, Chansky K, Lara PN Jr, Gumerlock PH, Crowley J, Albain KS, Vogel SJ, Gandara DR; Southwest Oncology Group.

J Thorac Oncol. 2009 Jan;4(1):87-92. doi: 10.1097/JTO.0b013e3181915052.

15.

Promotion of lung carcinogenesis by chronic obstructive pulmonary disease-like airway inflammation in a K-ras-induced mouse model.

Moghaddam SJ, Li H, Cho SN, Dishop MK, Wistuba II, Ji L, Kurie JM, Dickey BF, Demayo FJ.

Am J Respir Cell Mol Biol. 2009 Apr;40(4):443-53. doi: 10.1165/rcmb.2008-0198OC. Epub 2008 Oct 16.

16.

Cancer-related inflammation.

Mantovani A, Allavena P, Sica A, Balkwill F.

Nature. 2008 Jul 24;454(7203):436-44. doi: 10.1038/nature07205. Review.

PMID:
18650914
17.

Itch: a HECT-type E3 ligase regulating immunity, skin and cancer.

Melino G, Gallagher E, Aqeilan RI, Knight R, Peschiaroli A, Rossi M, Scialpi F, Malatesta M, Zocchi L, Browne G, Ciechanover A, Bernassola F.

Cell Death Differ. 2008 Jul;15(7):1103-12. doi: 10.1038/cdd.2008.60. Review.

18.

The E3 ubiquitin ligase Itch regulates expression of transcription factor Foxp3 and airway inflammation by enhancing the function of transcription factor TIEG1.

Venuprasad K, Huang H, Harada Y, Elly C, Subramaniam M, Spelsberg T, Su J, Liu YC.

Nat Immunol. 2008 Mar;9(3):245-53. doi: 10.1038/ni1564. Epub 2008 Feb 17.

19.

Shared principles in NF-kappaB signaling.

Hayden MS, Ghosh S.

Cell. 2008 Feb 8;132(3):344-62. doi: 10.1016/j.cell.2008.01.020. Review.

20.

The E3 ligase Itch negatively regulates inflammatory signaling pathways by controlling the function of the ubiquitin-editing enzyme A20.

Shembade N, Harhaj NS, Parvatiyar K, Copeland NG, Jenkins NA, Matesic LE, Harhaj EW.

Nat Immunol. 2008 Mar;9(3):254-62. doi: 10.1038/ni1563. Epub 2008 Feb 3.

PMID:
18246070

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