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Items: 1 to 20 of 67

1.

Autoregulation of Parkin activity through its ubiquitin-like domain.

Chaugule VK, Burchell L, Barber KR, Sidhu A, Leslie SJ, Shaw GS, Walden H.

EMBO J. 2011 Jun 21;30(14):2853-67. doi: 10.1038/emboj.2011.204.

2.

Preconditioning involves selective mitophagy mediated by Parkin and p62/SQSTM1.

Huang C, Andres AM, Ratliff EP, Hernandez G, Lee P, Gottlieb RA.

PLoS One. 2011;6(6):e20975. doi: 10.1371/journal.pone.0020975. Epub 2011 Jun 8.

3.

The PINK1/Parkin pathway regulates mitochondrial dynamics and function in mammalian hippocampal and dopaminergic neurons.

Yu W, Sun Y, Guo S, Lu B.

Hum Mol Genet. 2011 Aug 15;20(16):3227-40. doi: 10.1093/hmg/ddr235. Epub 2011 May 25.

4.

PTEN-inducible kinase 1 (PINK1)/Park6 is indispensable for normal heart function.

Billia F, Hauck L, Konecny F, Rao V, Shen J, Mak TW.

Proc Natl Acad Sci U S A. 2011 Jun 7;108(23):9572-7. doi: 10.1073/pnas.1106291108. Epub 2011 May 23.

5.

Parkin mediates proteasome-dependent protein degradation and rupture of the outer mitochondrial membrane.

Yoshii SR, Kishi C, Ishihara N, Mizushima N.

J Biol Chem. 2011 Jun 3;286(22):19630-40. doi: 10.1074/jbc.M110.209338. Epub 2011 Mar 18.

6.

The mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 trafficking.

Meissner C, Lorenz H, Weihofen A, Selkoe DJ, Lemberg MK.

J Neurochem. 2011 Jun;117(5):856-67. doi: 10.1111/j.1471-4159.2011.07253.x. Epub 2011 Apr 13.

7.

Mutations in PINK1 and Parkin impair ubiquitination of Mitofusins in human fibroblasts.

Rakovic A, Grünewald A, Kottwitz J, Brüggemann N, Pramstaller PP, Lohmann K, Klein C.

PLoS One. 2011 Mar 8;6(3):e16746. doi: 10.1371/journal.pone.0016746.

8.

PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease.

Shin JH, Ko HS, Kang H, Lee Y, Lee YI, Pletinkova O, Troconso JC, Dawson VL, Dawson TM.

Cell. 2011 Mar 4;144(5):689-702. doi: 10.1016/j.cell.2011.02.010.

9.

Functional alteration of PARL contributes to mitochondrial dysregulation in Parkinson's disease.

Shi G, Lee JR, Grimes DA, Racacho L, Ye D, Yang H, Ross OA, Farrer M, McQuibban GA, Bulman DE.

Hum Mol Genet. 2011 May 15;20(10):1966-74. doi: 10.1093/hmg/ddr077. Epub 2011 Feb 25.

PMID:
21355049
10.

Broad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagy.

Chan NC, Salazar AM, Pham AH, Sweredoski MJ, Kolawa NJ, Graham RL, Hess S, Chan DC.

Hum Mol Genet. 2011 May 1;20(9):1726-37. doi: 10.1093/hmg/ddr048. Epub 2011 Feb 4.

11.

Parkin ubiquitinates Drp1 for proteasome-dependent degradation: implication of dysregulated mitochondrial dynamics in Parkinson disease.

Wang H, Song P, Du L, Tian W, Yue W, Liu M, Li D, Wang B, Zhu Y, Cao C, Zhou J, Chen Q.

J Biol Chem. 2011 Apr 1;286(13):11649-58. doi: 10.1074/jbc.M110.144238. Epub 2011 Feb 3.

12.

Toxin-induced and genetic animal models of Parkinson's disease.

Hisahara S, Shimohama S.

Parkinsons Dis. 2010 Dec 22;2011:951709. doi: 10.4061/2011/951709.

13.

Genetic mouse models for Parkinson's disease display severe pathology in glial cell mitochondria.

Schmidt S, Linnartz B, Mendritzki S, Sczepan T, Lübbert M, Stichel CC, Lübbert H.

Hum Mol Genet. 2011 Mar 15;20(6):1197-211. doi: 10.1093/hmg/ddq564. Epub 2011 Jan 6.

PMID:
21212098
14.

Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin.

Tanaka A, Cleland MM, Xu S, Narendra DP, Suen DF, Karbowski M, Youle RJ.

J Cell Biol. 2010 Dec 27;191(7):1367-80. doi: 10.1083/jcb.201007013. Epub 2010 Dec 20.

15.

The loss of PGAM5 suppresses the mitochondrial degeneration caused by inactivation of PINK1 in Drosophila.

Imai Y, Kanao T, Sawada T, Kobayashi Y, Moriwaki Y, Ishida Y, Takeda K, Ichijo H, Lu B, Takahashi R.

PLoS Genet. 2010 Dec 2;6(12):e1001229. doi: 10.1371/journal.pgen.1001229.

16.
17.

PINK1 cleavage at position A103 by the mitochondrial protease PARL.

Deas E, Plun-Favreau H, Gandhi S, Desmond H, Kjaer S, Loh SH, Renton AE, Harvey RJ, Whitworth AJ, Martins LM, Abramov AY, Wood NW.

Hum Mol Genet. 2011 Mar 1;20(5):867-79. doi: 10.1093/hmg/ddq526. Epub 2010 Dec 6.

18.

Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL.

Jin SM, Lazarou M, Wang C, Kane LA, Narendra DP, Youle RJ.

J Cell Biol. 2010 Nov 29;191(5):933-42. doi: 10.1083/jcb.201008084.

19.

Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress.

Bouman L, Schlierf A, Lutz AK, Shan J, Deinlein A, Kast J, Galehdar Z, Palmisano V, Patenge N, Berg D, Gasser T, Augustin R, Trümbach D, Irrcher I, Park DS, Wurst W, Kilberg MS, Tatzelt J, Winklhofer KF.

Cell Death Differ. 2011 May;18(5):769-82. doi: 10.1038/cdd.2010.142. Epub 2010 Nov 26.

20.

Neurodegeneration in mnd2 mutant mice is not prevented by parkin transgene.

Yoshida T, Mizuta T, Shimizu S.

Biochem Biophys Res Commun. 2010 Nov 26;402(4):676-9. doi: 10.1016/j.bbrc.2010.10.083. Epub 2010 Oct 29.

PMID:
20971077

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