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Genetic analyses of integrin signaling.

Wickström SA, Radovanac K, Fässler R.

Cold Spring Harb Perspect Biol. 2011 Feb 1;3(2). pii: a005116. doi: 10.1101/cshperspect.a005116. Review.


The Structure of the talin head reveals a novel extended conformation of the FERM domain.

Elliott PR, Goult BT, Kopp PM, Bate N, Grossmann JG, Roberts GC, Critchley DR, Barsukov IL.

Structure. 2010 Oct 13;18(10):1289-99. doi: 10.1016/j.str.2010.07.011.


Vinculin, an adapter protein in control of cell adhesion signalling.

Carisey A, Ballestrem C.

Eur J Cell Biol. 2011 Feb-Mar;90(2-3):157-63. doi: 10.1016/j.ejcb.2010.06.007. Epub 2010 Jul 23. Review.


Central region of talin has a unique fold that binds vinculin and actin.

Gingras AR, Bate N, Goult BT, Patel B, Kopp PM, Emsley J, Barsukov IL, Roberts GC, Critchley DR.

J Biol Chem. 2010 Sep 17;285(38):29577-87. doi: 10.1074/jbc.M109.095455. Epub 2010 Jul 7.


Studies on the morphology and spreading of human endothelial cells define key inter- and intramolecular interactions for talin1.

Kopp PM, Bate N, Hansen TM, Brindle NP, Praekelt U, Debrand E, Coleman S, Mazzeo D, Goult BT, Gingras AR, Pritchard CA, Critchley DR, Monkley SJ.

Eur J Cell Biol. 2010 Sep;89(9):661-73. doi: 10.1016/j.ejcb.2010.05.003.


Role of kinase-independent and -dependent functions of FAK in endothelial cell survival and barrier function during embryonic development.

Zhao X, Peng X, Sun S, Park AY, Guan JL.

J Cell Biol. 2010 Jun 14;189(6):955-65. doi: 10.1083/jcb.200912094. Epub 2010 Jun 7.


Knock-in mutation reveals an essential role for focal adhesion kinase activity in blood vessel morphogenesis and cell motility-polarity but not cell proliferation.

Lim ST, Chen XL, Tomar A, Miller NL, Yoo J, Schlaepfer DD.

J Biol Chem. 2010 Jul 9;285(28):21526-36. doi: 10.1074/jbc.M110.129999. Epub 2010 May 4.


Recreation of the terminal events in physiological integrin activation.

Ye F, Hu G, Taylor D, Ratnikov B, Bobkov AA, McLean MA, Sligar SG, Taylor KA, Ginsberg MH.

J Cell Biol. 2010 Jan 11;188(1):157-73. doi: 10.1083/jcb.200908045. Epub 2010 Jan 4.


The structure of an integrin/talin complex reveals the basis of inside-out signal transduction.

Anthis NJ, Wegener KL, Ye F, Kim C, Goult BT, Lowe ED, Vakonakis I, Bate N, Critchley DR, Ginsberg MH, Campbell ID.

EMBO J. 2009 Nov 18;28(22):3623-32. doi: 10.1038/emboj.2009.287. Epub 2009 Oct 1.


Talin 1 and 2 are required for myoblast fusion, sarcomere assembly and the maintenance of myotendinous junctions.

Conti FJ, Monkley SJ, Wood MR, Critchley DR, Müller U.

Development. 2009 Nov;136(21):3597-606. doi: 10.1242/dev.035857. Epub 2009 Sep 30.


Complete focal adhesion kinase deficiency in the mammary gland causes ductal dilation and aberrant branching morphogenesis through defects in Rho kinase-dependent cell contractility.

van Miltenburg MH, Lalai R, de Bont H, van Waaij E, Beggs H, Danen EH, van de Water B.

FASEB J. 2009 Oct;23(10):3482-93. doi: 10.1096/fj.08-123398. Epub 2009 Jul 7.


Biochemical and structural properties of the integrin-associated cytoskeletal protein talin.

Critchley DR.

Annu Rev Biophys. 2009;38:235-54. doi: 10.1146/annurev.biophys.050708.133744. Review.


The structure of an interdomain complex that regulates talin activity.

Goult BT, Bate N, Anthis NJ, Wegener KL, Gingras AR, Patel B, Barsukov IL, Campbell ID, Roberts GC, Critchley DR.

J Biol Chem. 2009 May 29;284(22):15097-106. doi: 10.1074/jbc.M900078200. Epub 2009 Mar 18.


Control of high affinity interactions in the talin C terminus: how talin domains coordinate protein dynamics in cell adhesions.

Himmel M, Ritter A, Rothemund S, Pauling BV, Rottner K, Gingras AR, Ziegler WH.

J Biol Chem. 2009 May 15;284(20):13832-42. doi: 10.1074/jbc.M900266200. Epub 2009 Mar 11.


Signal co-operation between integrins and other receptor systems.

Streuli CH, Akhtar N.

Biochem J. 2009 Mar 15;418(3):491-506. doi: 10.1042/BJ20081948. Review.


Stretching single talin rod molecules activates vinculin binding.

del Rio A, Perez-Jimenez R, Liu R, Roca-Cusachs P, Fernandez JM, Sheetz MP.

Science. 2009 Jan 30;323(5914):638-41. doi: 10.1126/science.1162912.


Structural determinants of integrin binding to the talin rod.

Gingras AR, Ziegler WH, Bobkov AA, Joyce MG, Fasci D, Himmel M, Rothemund S, Ritter A, Grossmann JG, Patel B, Bate N, Goult BT, Emsley J, Barsukov IL, Roberts GC, Liddington RC, Ginsberg MH, Critchley DR.

J Biol Chem. 2009 Mar 27;284(13):8866-76. doi: 10.1074/jbc.M805937200. Epub 2009 Jan 27.


Talin depletion reveals independence of initial cell spreading from integrin activation and traction.

Zhang X, Jiang G, Cai Y, Monkley SJ, Critchley DR, Sheetz MP.

Nat Cell Biol. 2008 Sep;10(9):1062-8. doi: 10.1038/ncb1765.


Ras- and PI3K-dependent breast tumorigenesis in mice and humans requires focal adhesion kinase signaling.

Pylayeva Y, Gillen KM, Gerald W, Beggs HE, Reichardt LF, Giancotti FG.

J Clin Invest. 2009 Feb;119(2):252-66. doi: 10.1172/JCI37160. Epub 2009 Jan 19.


Mechanisms that regulate adaptor binding to beta-integrin cytoplasmic tails.

Legate KR, Fässler R.

J Cell Sci. 2009 Jan 15;122(Pt 2):187-98. doi: 10.1242/jcs.041624. Review.

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