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Items: 1 to 20 of 28

1.

Activity-induced Notch signaling in neurons requires Arc/Arg3.1 and is essential for synaptic plasticity in hippocampal networks.

Alberi L, Liu S, Wang Y, Badie R, Smith-Hicks C, Wu J, Pierfelice TJ, Abazyan B, Mattson MP, Kuhl D, Pletnikov M, Worley PF, Gaiano N.

Neuron. 2011 Feb 10;69(3):437-44. doi: 10.1016/j.neuron.2011.01.004.

2.

Novel research horizons for presenilins and γ-secretases in cell biology and disease.

De Strooper B, Annaert W.

Annu Rev Cell Dev Biol. 2010;26:235-60. doi: 10.1146/annurev-cellbio-100109-104117. Review.

PMID:
20604710
3.

A specific requirement of Arc/Arg3.1 for visual experience-induced homeostatic synaptic plasticity in mouse primary visual cortex.

Gao M, Sossa K, Song L, Errington L, Cummings L, Hwang H, Kuhl D, Worley P, Lee HK.

J Neurosci. 2010 May 26;30(21):7168-78. doi: 10.1523/JNEUROSCI.1067-10.2010.

4.

An APP inhibitory domain containing the Flemish mutation residue modulates gamma-secretase activity for Abeta production.

Tian Y, Bassit B, Chau D, Li YM.

Nat Struct Mol Biol. 2010 Feb;17(2):151-8. doi: 10.1038/nsmb.1743. Epub 2010 Jan 10.

PMID:
20062056
5.

Amyloid deposition is associated with impaired default network function in older persons without dementia.

Sperling RA, Laviolette PS, O'Keefe K, O'Brien J, Rentz DM, Pihlajamaki M, Marshall G, Hyman BT, Selkoe DJ, Hedden T, Buckner RL, Becker JA, Johnson KA.

Neuron. 2009 Jul 30;63(2):178-88. doi: 10.1016/j.neuron.2009.07.003.

6.

An exo-cell assay for examining real-time gamma-secretase activity and inhibition.

Shelton CC, Tian Y, Frattini MG, Li YM.

Mol Neurodegener. 2009 Jun 2;4:22. doi: 10.1186/1750-1326-4-22.

7.

Amyloid precursor protein trafficking, processing, and function.

Thinakaran G, Koo EH.

J Biol Chem. 2008 Oct 31;283(44):29615-9. doi: 10.1074/jbc.R800019200. Epub 2008 Jul 23. Review.

8.

Endocytosis is required for synaptic activity-dependent release of amyloid-beta in vivo.

Cirrito JR, Kang JE, Lee J, Stewart FR, Verges DK, Silverio LM, Bu G, Mennerick S, Holtzman DM.

Neuron. 2008 Apr 10;58(1):42-51. doi: 10.1016/j.neuron.2008.02.003.

9.
10.

Arc/Arg3.1 mediates homeostatic synaptic scaling of AMPA receptors.

Shepherd JD, Rumbaugh G, Wu J, Chowdhury S, Plath N, Kuhl D, Huganir RL, Worley PF.

Neuron. 2006 Nov 9;52(3):475-84.

11.

Arc/Arg3.1 interacts with the endocytic machinery to regulate AMPA receptor trafficking.

Chowdhury S, Shepherd JD, Okuno H, Lyford G, Petralia RS, Plath N, Kuhl D, Huganir RL, Worley PF.

Neuron. 2006 Nov 9;52(3):445-59.

12.
13.

Amyloidogenic processing of beta-amyloid precursor protein in intracellular compartments.

Vetrivel KS, Thinakaran G.

Neurology. 2006 Jan 24;66(2 Suppl 1):S69-73. Review.

PMID:
16432149
14.

Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo.

Cirrito JR, Yamada KA, Finn MB, Sloviter RS, Bales KR, May PC, Schoepp DD, Paul SM, Mennerick S, Holtzman DM.

Neuron. 2005 Dec 22;48(6):913-22.

15.

Molecular, structural, and functional characterization of Alzheimer's disease: evidence for a relationship between default activity, amyloid, and memory.

Buckner RL, Snyder AZ, Shannon BJ, LaRossa G, Sachs R, Fotenos AF, Sheline YI, Klunk WE, Mathis CA, Morris JC, Mintun MA.

J Neurosci. 2005 Aug 24;25(34):7709-17.

16.

Spatial segregation of gamma-secretase and substrates in distinct membrane domains.

Vetrivel KS, Cheng H, Kim SH, Chen Y, Barnes NY, Parent AT, Sisodia SS, Thinakaran G.

J Biol Chem. 2005 Jul 8;280(27):25892-900. Epub 2005 May 10.

17.

Environmental enrichment reduces Abeta levels and amyloid deposition in transgenic mice.

Lazarov O, Robinson J, Tang YP, Hairston IS, Korade-Mirnics Z, Lee VM, Hersh LB, Sapolsky RM, Mirnics K, Sisodia SS.

Cell. 2005 Mar 11;120(5):701-13.

18.

Neuroinflammation alters the hippocampal pattern of behaviorally induced Arc expression.

Rosi S, Ramirez-Amaya V, Vazdarjanova A, Worley PF, Barnes CA, Wenk GL.

J Neurosci. 2005 Jan 19;25(3):723-31.

19.

A novel series of potent gamma-secretase inhibitors based on a benzobicyclo[4.2.1]nonane core.

Lewis SJ, Smith AL, Neduvelil JG, Stevenson GI, Lindon MJ, Jones AB, Shearman MS, Beher D, Clarke E, Best JD, Peachey JE, Harrison T, Castro JL.

Bioorg Med Chem Lett. 2005 Jan 17;15(2):373-8.

PMID:
15603957
20.

Synaptic targeting by Alzheimer's-related amyloid beta oligomers.

Lacor PN, Buniel MC, Chang L, Fernandez SJ, Gong Y, Viola KL, Lambert MP, Velasco PT, Bigio EH, Finch CE, Krafft GA, Klein WL.

J Neurosci. 2004 Nov 10;24(45):10191-200.

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