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cAMP-responsive element modulator (CREM)α protein signaling mediates epigenetic remodeling of the human interleukin-2 gene: implications in systemic lupus erythematosus.

Hedrich CM, Rauen T, Tsokos GC.

J Biol Chem. 2011 Dec 16;286(50):43429-36. doi: 10.1074/jbc.M111.299339. Epub 2011 Oct 5.


A novel intronic cAMP response element modulator (CREM) promoter is regulated by activator protein-1 (AP-1) and accounts for altered activation-induced CREM expression in T cells from patients with systemic lupus erythematosus.

Rauen T, Benedyk K, Juang YT, Kerkhoff C, Kyttaris VC, Roth J, Tsokos GC, Tenbrock K.

J Biol Chem. 2011 Sep 16;286(37):32366-72. doi: 10.1074/jbc.M111.245811. Epub 2011 Jul 13.


The interleukin-17 cytokine family: critical players in host defence and inflammatory diseases.

Pappu R, Ramirez-Carrozzi V, Sambandam A.

Immunology. 2011 Sep;134(1):8-16. doi: 10.1111/j.1365-2567.2011.03465.x. Epub 2011 Jul 4. Review.


The DNMT3 family of mammalian de novo DNA methyltransferases.

Chédin F.

Prog Mol Biol Transl Sci. 2011;101:255-85. doi: 10.1016/B978-0-12-387685-0.00007-X. Review.


Epigenetics and autoimmunity, with special emphasis on methylation.

Renaudineau Y, Youinou P.

Keio J Med. 2011;60(1):10-6. Review.


Functional relevance of T helper 17 (Th17) cells and the IL-17 cytokine family in inflammatory bowel disease.

Hundorfean G, Neurath MF, Mudter J.

Inflamm Bowel Dis. 2012 Jan;18(1):180-6. doi: 10.1002/ibd.21677. Epub 2011 Mar 4. Review.


Promoter hypomethylation results in increased expression of protein phosphatase 2A in T cells from patients with systemic lupus erythematosus.

Sunahori K, Juang YT, Kyttaris VC, Tsokos GC.

J Immunol. 2011 Apr 1;186(7):4508-17. doi: 10.4049/jimmunol.1000340. Epub 2011 Feb 23.


Signal transduction pathways and transcriptional regulation in Th17 cell differentiation.

Hirahara K, Ghoreschi K, Laurence A, Yang XP, Kanno Y, O'Shea JJ.

Cytokine Growth Factor Rev. 2010 Dec;21(6):425-34. doi: 10.1016/j.cytogfr.2010.10.006. Epub 2010 Nov 16. Review.


Epigenetic mechanisms in lupus.

Patel DR, Richardson BC.

Curr Opin Rheumatol. 2010 Sep;22(5):478-82. doi: 10.1097/BOR.0b013e32833ae915. Review.


Overexpression of the growth arrest and DNA damage-induced 45alpha gene contributes to autoimmunity by promoting DNA demethylation in lupus T cells.

Li Y, Zhao M, Yin H, Gao F, Wu X, Luo Y, Zhao S, Zhang X, Su Y, Hu N, Long H, Richardson B, Lu Q.

Arthritis Rheum. 2010 May;62(5):1438-47. doi: 10.1002/art.27363.


Interleukin-17 and systemic lupus erythematosus: current concepts.

Nalbandian A, Crispín JC, Tsokos GC.

Clin Exp Immunol. 2009 Aug;157(2):209-15. doi: 10.1111/j.1365-2249.2009.03944.x. Review.


The cyclic AMP response element modulator {alpha} suppresses CD86 expression and APC function.

Ahlmann M, Varga G, Sturm K, Lippe R, Benedyk K, Viemann D, Scholzen T, Ehrchen J, Müller FU, Seidl M, Matus M, Tsokos GC, Roth J, Tenbrock K.

J Immunol. 2009 Apr 1;182(7):4167-74. doi: 10.4049/jimmunol.0802976. Erratum in: J Immunol. 2009 Jul 1;183(1):770.


Th17 and regulatory T cells: rebalancing pro- and anti-inflammatory forces in autoimmune arthritis.

Nistala K, Wedderburn LR.

Rheumatology (Oxford). 2009 Jun;48(6):602-6. doi: 10.1093/rheumatology/kep028. Epub 2009 Mar 5. Review.


The roles of IL-17A in inflammatory immune responses and host defense against pathogens.

Iwakura Y, Nakae S, Saijo S, Ishigame H.

Immunol Rev. 2008 Dec;226:57-79. doi: 10.1111/j.1600-065X.2008.00699.x. Review.


Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells.

Wei G, Wei L, Zhu J, Zang C, Hu-Li J, Yao Z, Cui K, Kanno Y, Roh TY, Watford WT, Schones DE, Peng W, Sun HW, Paul WE, O'Shea JJ, Zhao K.

Immunity. 2009 Jan 16;30(1):155-67. doi: 10.1016/j.immuni.2008.12.009.


Expanded double negative T cells in patients with systemic lupus erythematosus produce IL-17 and infiltrate the kidneys.

Crispín JC, Oukka M, Bayliss G, Cohen RA, Van Beek CA, Stillman IE, Kyttaris VC, Juang YT, Tsokos GC.

J Immunol. 2008 Dec 15;181(12):8761-6.


IL-21 and TGF-beta are required for differentiation of human T(H)17 cells.

Yang L, Anderson DE, Baecher-Allan C, Hastings WD, Bettelli E, Oukka M, Kuchroo VK, Hafler DA.

Nature. 2008 Jul 17;454(7202):350-2. doi: 10.1038/nature07021. Epub 2008 May 11.


Epigenetics in human autoimmunity. Epigenetics in autoimmunity - DNA methylation in systemic lupus erythematosus and beyond.

Strickland FM, Richardson BC.

Autoimmunity. 2008 May;41(4):278-86. doi: 10.1080/08916930802024616. Review.


Signal transduction pathways and transcriptional regulation in the control of Th17 differentiation.

Chen Z, Laurence A, O'Shea JJ.

Semin Immunol. 2007 Dec;19(6):400-8. doi: 10.1016/j.smim.2007.10.015. Epub 2007 Dec 31. Review.

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