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Nanomechanics of functional and pathological amyloid materials.

Knowles TP, Buehler MJ.

Nat Nanotechnol. 2011 Jul 31;6(8):469-79. doi: 10.1038/nnano.2011.102. Review.


Molecular chaperones in protein folding and proteostasis.

Hartl FU, Bracher A, Hayer-Hartl M.

Nature. 2011 Jul 20;475(7356):324-32. doi: 10.1038/nature10317. Review.


The stress of protein misfolding: from single cells to multicellular organisms.

Gidalevitz T, Prahlad V, Morimoto RI.

Cold Spring Harb Perspect Biol. 2011 Jun 1;3(6). pii: a009704. doi: 10.1101/cshperspect.a009704. Review.


Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways.

Chou TF, Brown SJ, Minond D, Nordin BE, Li K, Jones AC, Chase P, Porubsky PR, Stoltz BM, Schoenen FJ, Patricelli MP, Hodder P, Rosen H, Deshaies RJ.

Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):4834-9. doi: 10.1073/pnas.1015312108. Epub 2011 Mar 7.


Integration of clearance mechanisms: the proteasome and autophagy.

Wong E, Cuervo AM.

Cold Spring Harb Perspect Biol. 2010 Dec;2(12):a006734. doi: 10.1101/cshperspect.a006734. Epub 2010 Nov 10. Review.


Epigenetics in the extreme: prions and the inheritance of environmentally acquired traits.

Halfmann R, Lindquist S.

Science. 2010 Oct 29;330(6004):629-32. doi: 10.1126/science.1191081.


Conversion of a yeast prion protein to an infectious form in bacteria.

Garrity SJ, Sivanathan V, Dong J, Lindquist S, Hochschild A.

Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10596-601. doi: 10.1073/pnas.0913280107. Epub 2010 May 19.


Prion-like disorders: blurring the divide between transmissibility and infectivity.

Cushman M, Johnson BS, King OD, Gitler AD, Shorter J.

J Cell Sci. 2010 Apr 15;123(Pt 8):1191-201. doi: 10.1242/jcs.051672.


Discovery and characterization of a mammalian amyloid disaggregation activity.

Murray AN, Solomon JP, Wang YJ, Balch WE, Kelly JW.

Protein Sci. 2010 Apr;19(4):836-46. doi: 10.1002/pro.363.


Applying Hsp104 to protein-misfolding disorders.

Vashist S, Cushman M, Shorter J.

Biochem Cell Biol. 2010 Feb;88(1):1-13. doi: 10.1139/o09-121. Review.


A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells.

Massey AJ, Williamson DS, Browne H, Murray JB, Dokurno P, Shaw T, Macias AT, Daniels Z, Geoffroy S, Dopson M, Lavan P, Matassova N, Francis GL, Graham CJ, Parsons R, Wang Y, Padfield A, Comer M, Drysdale MJ, Wood M.

Cancer Chemother Pharmacol. 2010 Aug;66(3):535-45. doi: 10.1007/s00280-009-1194-3. Epub 2009 Dec 13.


A kinetic assessment of the C. elegans amyloid disaggregation activity enables uncoupling of disassembly and proteolysis.

Bieschke J, Cohen E, Murray A, Dillin A, Kelly JW.

Protein Sci. 2009 Nov;18(11):2231-41. doi: 10.1002/pro.234. Erratum in: Protein Sci. 2013 Nov;22(11):1688.


Prion proteostasis: Hsp104 meets its supporting cast.

Sweeny EA, Shorter J.

Prion. 2008 Oct-Dec;2(4):135-40. Epub 2008 Oct 22. Review.


In vivo monitoring of the prion replication cycle reveals a critical role for Sis1 in delivering substrates to Hsp104.

Tipton KA, Verges KJ, Weissman JS.

Mol Cell. 2008 Nov 21;32(4):584-91. doi: 10.1016/j.molcel.2008.11.003.


Hsp104 and ClpB: protein disaggregating machines.

Doyle SM, Wickner S.

Trends Biochem Sci. 2009 Jan;34(1):40-8. doi: 10.1016/j.tibs.2008.09.010. Epub 2008 Nov 12. Review.


Hsp104, Hsp70 and Hsp40 interplay regulates formation, growth and elimination of Sup35 prions.

Shorter J, Lindquist S.

EMBO J. 2008 Oct 22;27(20):2712-24. doi: 10.1038/emboj.2008.194. Epub 2008 Oct 2.


p97 Homologs from Caenorhabditis elegans, CDC-48.1 and CDC-48.2, suppress the aggregate formation of huntingtin exon1 containing expanded polyQ repeat.

Nishikori S, Yamanaka K, Sakurai T, Esaki M, Ogura T.

Genes Cells. 2008 Aug;13(8):827-38. doi: 10.1111/j.1365-2443.2008.01214.x. Epub 2008 Jul 31.


Prion-impairing mutations in Hsp70 chaperone Ssa1: effects on ATPase and chaperone activities.

Needham PG, Masison DC.

Arch Biochem Biophys. 2008 Oct 15;478(2):167-74. doi: 10.1016/ Epub 2008 Aug 6.


Hsp104 antagonizes alpha-synuclein aggregation and reduces dopaminergic degeneration in a rat model of Parkinson disease.

Lo Bianco C, Shorter J, RĂ©gulier E, Lashuel H, Iwatsubo T, Lindquist S, Aebischer P.

J Clin Invest. 2008 Sep;118(9):3087-97. doi: 10.1172/JCI35781.


Structural and functional diversities between members of the human HSPB, HSPH, HSPA, and DNAJ chaperone families.

Vos MJ, Hageman J, Carra S, Kampinga HH.

Biochemistry. 2008 Jul 8;47(27):7001-11. doi: 10.1021/bi800639z. Epub 2008 Jun 17. Review.


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