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Items: 1 to 20 of 46


Epithelial EGF receptor signaling mediates airway hyperreactivity and remodeling in a mouse model of chronic asthma.

Le Cras TD, Acciani TH, Mushaben EM, Kramer EL, Pastura PA, Hardie WD, Korfhagen TR, Sivaprasad U, Ericksen M, Gibson AM, Holtzman MJ, Whitsett JA, Hershey GK.

Am J Physiol Lung Cell Mol Physiol. 2011 Mar;300(3):L414-21. doi: 10.1152/ajplung.00346.2010. Epub 2010 Dec 17.


The mammalian target of rapamycin: linking T cell differentiation, function, and metabolism.

Powell JD, Delgoffe GM.

Immunity. 2010 Sep 24;33(3):301-11. doi: 10.1016/j.immuni.2010.09.002. Review.


The S1P(1)-mTOR axis directs the reciprocal differentiation of T(H)1 and T(reg) cells.

Liu G, Yang K, Burns S, Shrestha S, Chi H.

Nat Immunol. 2010 Nov;11(11):1047-56. doi: 10.1038/ni.1939. Epub 2010 Sep 19.


Importance of cytokines in murine allergic airway disease and human asthma.

Finkelman FD, Hogan SP, Hershey GK, Rothenberg ME, Wills-Karp M.

J Immunol. 2010 Feb 15;184(4):1663-74. doi: 10.4049/jimmunol.0902185. Review.


mTOR signaling at a glance.

Laplante M, Sabatini DM.

J Cell Sci. 2009 Oct 15;122(Pt 20):3589-94. doi: 10.1242/jcs.051011. Review. No abstract available.


The multifunctional role of mTOR in innate immunity: implications for transplant immunity.

Säemann MD, Haidinger M, Hecking M, Hörl WH, Weichhart T.

Am J Transplant. 2009 Dec;9(12):2655-61. doi: 10.1111/j.1600-6143.2009.02832.x. Epub 2009 Sep 25. Review.


Innate cells and T helper 2 cell immunity in airway inflammation.

Barrett NA, Austen KF.

Immunity. 2009 Sep 18;31(3):425-37. doi: 10.1016/j.immuni.2009.08.014. Review.


Immunobiology of asthma.

Hamid Q, Tulic M.

Annu Rev Physiol. 2009;71:489-507. doi: 10.1146/annurev.physiol.010908.163200. Review.


The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment.

Delgoffe GM, Kole TP, Zheng Y, Zarek PE, Matthews KL, Xiao B, Worley PF, Kozma SC, Powell JD.

Immunity. 2009 Jun 19;30(6):832-44. doi: 10.1016/j.immuni.2009.04.014.


A protective role for C5a in the development of allergic asthma associated with altered levels of B7-H1 and B7-DC on plasmacytoid dendritic cells.

Zhang X, Lewkowich IP, Köhl G, Clark JR, Wills-Karp M, Köhl J.

J Immunol. 2009 Apr 15;182(8):5123-30. doi: 10.4049/jimmunol.0804276.


Early growth response-1 suppresses epidermal growth factor receptor-mediated airway hyperresponsiveness and lung remodeling in mice.

Kramer EL, Mushaben EM, Pastura PA, Acciani TH, Deutsch GH, Khurana Hershey GK, Korfhagen TR, Hardie WD, Whitsett JA, Le Cras TD.

Am J Respir Cell Mol Biol. 2009 Oct;41(4):415-25. doi: 10.1165/rcmb.2008-0470OC. Epub 2009 Feb 2.


Pathogenesis of asthma.

Holgate ST.

Clin Exp Allergy. 2008 Jun;38(6):872-97. doi: 10.1111/j.1365-2222.2008.02971.x. Review.


A review of anti-IgE monoclonal antibody (omalizumab) as add on therapy for severe allergic (IgE-mediated) asthma.

D'Amato G, Salzillo A, Piccolo A, D'Amato M, Liccardi G.

Ther Clin Risk Manag. 2007 Aug;3(4):613-9.


Activation and function of the mTORC1 pathway in mast cells.

Kim MS, Kuehn HS, Metcalfe DD, Gilfillan AM.

J Immunol. 2008 Apr 1;180(7):4586-95.


De novo induction of antigen-specific CD4+CD25+Foxp3+ regulatory T cells in vivo following systemic antigen administration accompanied by blockade of mTOR.

Kang J, Huddleston SJ, Fraser JM, Khoruts A.

J Leukoc Biol. 2008 May;83(5):1230-9. doi: 10.1189/jlb.1207851. Epub 2008 Feb 12.


Global strategy for asthma management and prevention: GINA executive summary.

Bateman ED, Hurd SS, Barnes PJ, Bousquet J, Drazen JM, FitzGerald M, Gibson P, Ohta K, O'Byrne P, Pedersen SE, Pizzichini E, Sullivan SD, Wenzel SE, Zar HJ.

Eur Respir J. 2008 Jan;31(1):143-78. doi: 10.1183/09031936.00138707.


Defining the role of mTOR in cancer.

Guertin DA, Sabatini DM.

Cancer Cell. 2007 Jul;12(1):9-22. Review.


Pharmacological modulation of the leukotriene pathway in allergic airway disease.

Montuschi P, Sala A, Dahlén SE, Folco G.

Drug Discov Today. 2007 May;12(9-10):404-12. Epub 2007 Mar 23. Review.


Targeting mammalian target of rapamycin (mTOR) for health and diseases.

Tsang CK, Qi H, Liu LF, Zheng XF.

Drug Discov Today. 2007 Feb;12(3-4):112-24. Epub 2006 Dec 15. Review. Erratum in: Drug Discov Today. 2008 Sep;13(17-18):824.


Selective survival of naturally occurring human CD4+CD25+Foxp3+ regulatory T cells cultured with rapamycin.

Strauss L, Whiteside TL, Knights A, Bergmann C, Knuth A, Zippelius A.

J Immunol. 2007 Jan 1;178(1):320-9.

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