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Items: 1 to 20 of 59

1.

Genetic and functional studies implicate HIF1α as a 14q kidney cancer suppressor gene.

Shen C, Beroukhim R, Schumacher SE, Zhou J, Chang M, Signoretti S, Kaelin WG Jr.

Cancer Discov. 2011 Aug;1(3):222-35. doi: 10.1158/2159-8290.CD-11-0098. Epub 2011 Jun 7.

2.

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis.

DeNicola GM, Karreth FA, Humpton TJ, Gopinathan A, Wei C, Frese K, Mangal D, Yu KH, Yeo CJ, Calhoun ES, Scrimieri F, Winter JM, Hruban RH, Iacobuzio-Donahue C, Kern SE, Blair IA, Tuveson DA.

Nature. 2011 Jul 6;475(7354):106-9. doi: 10.1038/nature10189.

3.

Aberrant succination of proteins in fumarate hydratase-deficient mice and HLRCC patients is a robust biomarker of mutation status.

Bardella C, El-Bahrawy M, Frizzell N, Adam J, Ternette N, Hatipoglu E, Howarth K, O'Flaherty L, Roberts I, Turner G, Taylor J, Giaslakiotis K, Macaulay VM, Harris AL, Chandra A, Lehtonen HJ, Launonen V, Aaltonen LA, Pugh CW, Mihai R, Trudgian D, Kessler B, Baynes JW, Ratcliffe PJ, Tomlinson IP, Pollard PJ.

J Pathol. 2011 Sep;225(1):4-11. doi: 10.1002/path.2932. Epub 2011 Jun 1.

PMID:
21630274
4.

Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1.

Luo W, Hu H, Chang R, Zhong J, Knabel M, O'Meally R, Cole RN, Pandey A, Semenza GL.

Cell. 2011 May 27;145(5):732-44. doi: 10.1016/j.cell.2011.03.054.

5.

Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway.

Linker RA, Lee DH, Ryan S, van Dam AM, Conrad R, Bista P, Zeng W, Hronowsky X, Buko A, Chollate S, Ellrichmann G, Brück W, Dawson K, Goelz S, Wiese S, Scannevin RH, Lukashev M, Gold R.

Brain. 2011 Mar;134(Pt 3):678-92. doi: 10.1093/brain/awq386.

PMID:
21354971
6.

Inborn and acquired metabolic defects in cancer.

Frezza C, Pollard PJ, Gottlieb E.

J Mol Med (Berl). 2011 Mar;89(3):213-20. doi: 10.1007/s00109-011-0728-4. Epub 2011 Feb 8. Review.

7.

Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolution.

Taguchi K, Motohashi H, Yamamoto M.

Genes Cells. 2011 Feb;16(2):123-40. doi: 10.1111/j.1365-2443.2010.01473.x. Review.

8.

Expression profiling in progressive stages of fumarate-hydratase deficiency: the contribution of metabolic changes to tumorigenesis.

Ashrafian H, O'Flaherty L, Adam J, Steeples V, Chung YL, East P, Vanharanta S, Lehtonen H, Nye E, Hatipoglu E, Miranda M, Howarth K, Shukla D, Troy H, Griffiths J, Spencer-Dene B, Yusuf M, Volpi E, Maxwell PH, Stamp G, Poulsom R, Pugh CW, Costa B, Bardella C, Di Renzo MF, Kotlikoff MI, Launonen V, Aaltonen L, El-Bahrawy M, Tomlinson I, Pollard PJ.

Cancer Res. 2010 Nov 15;70(22):9153-65. doi: 10.1158/0008-5472.CAN-10-1949. Epub 2010 Oct 26.

9.

Succination of proteins in diabetes.

Frizzell N, Lima M, Baynes JW.

Free Radic Res. 2011 Jan;45(1):101-9. doi: 10.3109/10715762.2010.524643. Epub 2010 Oct 22. Review.

PMID:
20964553
10.

Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals.

McMahon M, Lamont DJ, Beattie KA, Hayes JD.

Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):18838-43. doi: 10.1073/pnas.1007387107. Epub 2010 Oct 18.

11.

Dysregulation of hypoxia pathways in fumarate hydratase-deficient cells is independent of defective mitochondrial metabolism.

O'Flaherty L, Adam J, Heather LC, Zhdanov AV, Chung YL, Miranda MX, Croft J, Olpin S, Clarke K, Pugh CW, Griffiths J, Papkovsky D, Ashrafian H, Ratcliffe PJ, Pollard PJ.

Hum Mol Genet. 2010 Oct 1;19(19):3844-51. doi: 10.1093/hmg/ddq305. Epub 2010 Jul 21.

12.

The Nrf2-Keap1-ARE signaling pathway: The regulation and dual function of Nrf2 in cancer.

Zhang DD.

Antioxid Redox Signal. 2010 Dec 1;13(11):1623-6. doi: 10.1089/ars.2010.3301. Epub 2010 Aug 23.

PMID:
20486759
13.

Cancer chemoprevention mechanisms mediated through the Keap1-Nrf2 pathway.

Hayes JD, McMahon M, Chowdhry S, Dinkova-Kostova AT.

Antioxid Redox Signal. 2010 Dec 1;13(11):1713-48. doi: 10.1089/ars.2010.3221. Epub 2010 Aug 14. Review.

PMID:
20446772
14.

HIF prolyl hydroxylase-3 mediates alpha-ketoglutarate-induced apoptosis and tumor suppression.

Tennant DA, Gottlieb E.

J Mol Med (Berl). 2010 Aug;88(8):839-49. doi: 10.1007/s00109-010-0627-0. Epub 2010 Apr 11.

PMID:
20383689
15.

Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes.

Dalgliesh GL, Furge K, Greenman C, Chen L, Bignell G, Butler A, Davies H, Edkins S, Hardy C, Latimer C, Teague J, Andrews J, Barthorpe S, Beare D, Buck G, Campbell PJ, Forbes S, Jia M, Jones D, Knott H, Kok CY, Lau KW, Leroy C, Lin ML, McBride DJ, Maddison M, Maguire S, McLay K, Menzies A, Mironenko T, Mulderrig L, Mudie L, O'Meara S, Pleasance E, Rajasingham A, Shepherd R, Smith R, Stebbings L, Stephens P, Tang G, Tarpey PS, Turrell K, Dykema KJ, Khoo SK, Petillo D, Wondergem B, Anema J, Kahnoski RJ, Teh BT, Stratton MR, Futreal PA.

Nature. 2010 Jan 21;463(7279):360-3. doi: 10.1038/nature08672. Epub 2010 Jan 6.

16.

Mutation analysis of hypoxia-inducible factors HIF1A and HIF2A in renal cell carcinoma.

Morris MR, Hughes DJ, Tian YM, Ricketts CJ, Lau KW, Gentle D, Shuib S, Serrano-Fernandez P, Lubinski J, Wiesener MS, Pugh CW, Latif F, Ratcliffe PJ, Maher ER.

Anticancer Res. 2009 Nov;29(11):4337-43.

17.

UOK 262 cell line, fumarate hydratase deficient (FH-/FH-) hereditary leiomyomatosis renal cell carcinoma: in vitro and in vivo model of an aberrant energy metabolic pathway in human cancer.

Yang Y, Valera VA, Padilla-Nash HM, Sourbier C, Vocke CD, Vira MA, Abu-Asab MS, Bratslavsky G, Tsokos M, Merino MJ, Pinto PA, Srinivasan R, Ried T, Neckers L, Linehan WM.

Cancer Genet Cytogenet. 2010 Jan 1;196(1):45-55. doi: 10.1016/j.cancergencyto.2009.08.018.

18.

Role of Nrf1 in antioxidant response element-mediated gene expression and beyond.

Biswas M, Chan JY.

Toxicol Appl Pharmacol. 2010 Apr 1;244(1):16-20. doi: 10.1016/j.taap.2009.07.034. Epub 2009 Aug 6. Review.

19.

Oxygen-regulated beta(2)-adrenergic receptor hydroxylation by EGLN3 and ubiquitylation by pVHL.

Xie L, Xiao K, Whalen EJ, Forrester MT, Freeman RS, Fong G, Gygi SP, Lefkowitz RJ, Stamler JS.

Sci Signal. 2009 Jul 7;2(78):ra33. doi: 10.1126/scisignal.2000444.

20.

Cancer. Puzzling patterns of predisposition.

Pollard PJ, Ratcliffe PJ.

Science. 2009 Apr 10;324(5924):192-4. doi: 10.1126/science.1173362. No abstract available.

PMID:
19359573

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