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Items: 1 to 20 of 84

1.

In vitro DNA tethering of HIV-1 integrase by the transcriptional coactivator LEDGF/p75.

McNeely M, Hendrix J, Busschots K, Boons E, Deleersnijder A, Gerard M, Christ F, Debyser Z.

J Mol Biol. 2011 Jul 29;410(5):811-30. doi: 10.1016/j.jmb.2011.03.073.

PMID:
21763490
2.

HIV-1 integrase modulates the interaction of the HIV-1 cellular cofactor LEDGF/p75 with chromatin.

Astiazaran P, Bueno MT, Morales E, Kugelman JR, Garcia-Rivera JA, Llano M.

Retrovirology. 2011 Apr 21;8:27. doi: 10.1186/1742-4690-8-27.

3.

Nuclear protein LEDGF/p75 recognizes supercoiled DNA by a novel DNA-binding domain.

Tsutsui KM, Sano K, Hosoya O, Miyamoto T, Tsutsui K.

Nucleic Acids Res. 2011 Jul;39(12):5067-81. doi: 10.1093/nar/gkr088. Epub 2011 Feb 23.

4.

The mechanism of retroviral integration from X-ray structures of its key intermediates.

Maertens GN, Hare S, Cherepanov P.

Nature. 2010 Nov 11;468(7321):326-9. doi: 10.1038/nature09517.

5.

The transcriptional co-activator LEDGF/p75 displays a dynamic scan-and-lock mechanism for chromatin tethering.

Hendrix J, Gijsbers R, De Rijck J, Voet A, Hotta J, McNeely M, Hofkens J, Debyser Z, Engelborghs Y.

Nucleic Acids Res. 2011 Mar;39(4):1310-25. doi: 10.1093/nar/gkq933. Epub 2010 Oct 25.

6.

Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers.

Vermeulen M, Eberl HC, Matarese F, Marks H, Denissov S, Butter F, Lee KK, Olsen JV, Hyman AA, Stunnenberg HG, Mann M.

Cell. 2010 Sep 17;142(6):967-80. doi: 10.1016/j.cell.2010.08.020.

7.

The Dnmt3a PWWP domain reads histone 3 lysine 36 trimethylation and guides DNA methylation.

Dhayalan A, Rajavelu A, Rathert P, Tamas R, Jurkowska RZ, Ragozin S, Jeltsch A.

J Biol Chem. 2010 Aug 20;285(34):26114-20. doi: 10.1074/jbc.M109.089433. Epub 2010 Jun 11.

8.

High-resolution profiling of the LEDGF/p75 chromatin interaction in the ENCODE region.

De Rijck J, Bartholomeeusen K, Ceulemans H, Debyser Z, Gijsbers R.

Nucleic Acids Res. 2010 Oct;38(18):6135-47. doi: 10.1093/nar/gkq410. Epub 2010 May 19.

9.

Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication.

Christ F, Voet A, Marchand A, Nicolet S, Desimmie BA, Marchand D, Bardiot D, Van der Veken NJ, Van Remoortel B, Strelkov SV, De Maeyer M, Chaltin P, Debyser Z.

Nat Chem Biol. 2010 Jun;6(6):442-8. doi: 10.1038/nchembio.370. Epub 2010 May 16.

PMID:
20473303
10.

Molecular basis of histone H3K36me3 recognition by the PWWP domain of Brpf1.

Vezzoli A, Bonadies N, Allen MD, Freund SM, Santiveri CM, Kvinlaug BT, Huntly BJ, Gƶttgens B, Bycroft M.

Nat Struct Mol Biol. 2010 May;17(5):617-9. doi: 10.1038/nsmb.1797. Epub 2010 Apr 18.

PMID:
20400950
11.

Identification of a second DNA binding site in human DNA methyltransferase 3A by substrate inhibition and domain deletion.

Purdy MM, Holz-Schietinger C, Reich NO.

Arch Biochem Biophys. 2010 Jun 1;498(1):13-22. doi: 10.1016/j.abb.2010.03.007. Epub 2010 Mar 17.

PMID:
20227382
12.

LEDGF hybrids efficiently retarget lentiviral integration into heterochromatin.

Gijsbers R, Ronen K, Vets S, Malani N, De Rijck J, McNeely M, Bushman FD, Debyser Z.

Mol Ther. 2010 Mar;18(3):552-60. doi: 10.1038/mt.2010.36. Epub 2010 Jan 5.

13.

Lens epithelium-derived growth factor fusion proteins redirect HIV-1 DNA integration.

Ferris AL, Wu X, Hughes CM, Stewart C, Smith SJ, Milne TA, Wang GG, Shun MC, Allis CD, Engelman A, Hughes SH.

Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3135-40. doi: 10.1073/pnas.0914142107. Epub 2010 Feb 1.

14.

Retroviral intasome assembly and inhibition of DNA strand transfer.

Hare S, Gupta SS, Valkov E, Engelman A, Cherepanov P.

Nature. 2010 Mar 11;464(7286):232-6. doi: 10.1038/nature08784. Epub 2010 Jan 31.

15.

Implication of serine residues 271, 273, and 275 in the human immunodeficiency virus type 1 cofactor activity of lens epithelium-derived growth factor/p75.

Garcia-Rivera JA, Bueno MT, Morales E, Kugelman JR, Rodriguez DF, Llano M.

J Virol. 2010 Jan;84(2):740-52. doi: 10.1128/JVI.01043-09. Epub 2009 Nov 4.

16.

Modification of integration site preferences of an HIV-1-based vector by expression of a novel synthetic protein.

Silvers RM, Smith JA, Schowalter M, Litwin S, Liang Z, Geary K, Daniel R.

Hum Gene Ther. 2010 Mar;21(3):337-49. doi: 10.1089/hum.2009.134.

17.

LEDGF/p75 proteins with alternative chromatin tethers are functional HIV-1 cofactors.

Meehan AM, Saenz DT, Morrison JH, Garcia-Rivera JA, Peretz M, Llano M, Poeschla EM.

PLoS Pathog. 2009 Jul;5(7):e1000522. doi: 10.1371/journal.ppat.1000522. Epub 2009 Jul 17.

18.

HIV integration site distributions in resting and activated CD4+ T cells infected in culture.

Brady T, Agosto LM, Malani N, Berry CC, O'Doherty U, Bushman F.

AIDS. 2009 Jul 31;23(12):1461-71. doi: 10.1097/QAD.0b013e32832caf28.

19.

A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replication.

Yeung ML, Houzet L, Yedavalli VS, Jeang KT.

J Biol Chem. 2009 Jul 17;284(29):19463-73. doi: 10.1074/jbc.M109.010033. Epub 2009 May 20.

20.

Highly efficient multicistronic lentiviral vectors with peptide 2A sequences.

Ibrahimi A, Vande Velde G, Reumers V, Toelen J, Thiry I, Vandeputte C, Vets S, Deroose C, Bormans G, Baekelandt V, Debyser Z, Gijsbers R.

Hum Gene Ther. 2009 Aug;20(8):845-60. doi: 10.1089/hum.2008.188.

PMID:
19419274

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