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Aβ Deposition in aging is associated with increases in brain activation during successful memory encoding.

Mormino EC, Brandel MG, Madison CM, Marks S, Baker SL, Jagust WJ.

Cereb Cortex. 2012 Aug;22(8):1813-23. doi: 10.1093/cercor/bhr255. Epub 2011 Sep 23.


Not quite PIB-positive, not quite PIB-negative: slight PIB elevations in elderly normal control subjects are biologically relevant.

Mormino EC, Brandel MG, Madison CM, Rabinovici GD, Marks S, Baker SL, Jagust WJ.

Neuroimage. 2012 Jan 16;59(2):1152-60. doi: 10.1016/j.neuroimage.2011.07.098. Epub 2011 Aug 22.


Hippocampal volume differences between healthy young apolipoprotein E ε2 and ε4 carriers.

Alexopoulos P, Richter-Schmidinger T, Horn M, Maus S, Reichel M, Sidiropoulos C, Rhein C, Lewczuk P, Doerfler A, Kornhuber J.

J Alzheimers Dis. 2011;26(2):207-10. doi: 10.3233/JAD-2011-110356.


Neuronal activity regulates the regional vulnerability to amyloid-β deposition.

Bero AW, Yan P, Roh JH, Cirrito JR, Stewart FR, Raichle ME, Lee JM, Holtzman DM.

Nat Neurosci. 2011 Jun;14(6):750-6. doi: 10.1038/nn.2801. Epub 2011 May 1.


Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease.

Sperling RA, Aisen PS, Beckett LA, Bennett DA, Craft S, Fagan AM, Iwatsubo T, Jack CR Jr, Kaye J, Montine TJ, Park DC, Reiman EM, Rowe CC, Siemers E, Stern Y, Yaffe K, Carrillo MC, Thies B, Morrison-Bogorad M, Wagster MV, Phelps CH.

Alzheimers Dement. 2011 May;7(3):280-92. doi: 10.1016/j.jalz.2011.03.003. Epub 2011 Apr 21.


Amyloid-dependent and amyloid-independent stages of Alzheimer disease.

Hyman BT.

Arch Neurol. 2011 Aug;68(8):1062-4. doi: 10.1001/archneurol.2011.70. Epub 2011 Apr 11. Review. No abstract available.


Relationships between β-amyloid and functional connectivity in different components of the default mode network in aging.

Mormino EC, Smiljic A, Hayenga AO, Onami SH, Greicius MD, Rabinovici GD, Janabi M, Baker SL, Yen IV, Madison CM, Miller BL, Jagust WJ.

Cereb Cortex. 2011 Oct;21(10):2399-407. doi: 10.1093/cercor/bhr025. Epub 2011 Mar 7.


Apolipoprotein E in Alzheimer's disease and other neurological disorders.

Verghese PB, Castellano JM, Holtzman DM.

Lancet Neurol. 2011 Mar;10(3):241-52. doi: 10.1016/S1474-4422(10)70325-2. Review.


Age and amyloid-related alterations in default network habituation to stimulus repetition.

Vannini P, Hedden T, Becker JA, Sullivan C, Putcha D, Rentz D, Johnson KA, Sperling RA.

Neurobiol Aging. 2012 Jul;33(7):1237-52. doi: 10.1016/j.neurobiolaging.2011.01.003. Epub 2011 Feb 18.


Anti-aβ therapeutics in Alzheimer's disease: the need for a paradigm shift.

Golde TE, Schneider LS, Koo EH.

Neuron. 2011 Jan 27;69(2):203-13. doi: 10.1016/j.neuron.2011.01.002.


Influence of brain-derived neurotrophic-factor and apolipoprotein E genetic variants on hippocampal volume and memory performance in healthy young adults.

Richter-Schmidinger T, Alexopoulos P, Horn M, Maus S, Reichel M, Rhein C, Lewczuk P, Sidiropoulos C, Kneib T, Perneczky R, Doerfler A, Kornhuber J.

J Neural Transm (Vienna). 2011 Feb;118(2):249-57. doi: 10.1007/s00702-010-0539-8. Epub 2010 Dec 29.


APOE4 allele disrupts resting state fMRI connectivity in the absence of amyloid plaques or decreased CSF Aβ42.

Sheline YI, Morris JC, Snyder AZ, Price JL, Yan Z, D'Angelo G, Liu C, Dixit S, Benzinger T, Fagan A, Goate A, Mintun MA.

J Neurosci. 2010 Dec 15;30(50):17035-40. doi: 10.1523/JNEUROSCI.3987-10.2010.


Reimagining Alzheimer's disease--an age-based hypothesis.

Herrup K.

J Neurosci. 2010 Dec 15;30(50):16755-62. doi: 10.1523/JNEUROSCI.4521-10.2010. Review.


Longitudinal evidence for diminished frontal cortex function in aging.

Nyberg L, Salami A, Andersson M, Eriksson J, Kalpouzos G, Kauppi K, Lind J, Pudas S, Persson J, Nilsson LG.

Proc Natl Acad Sci U S A. 2010 Dec 28;107(52):22682-6. doi: 10.1073/pnas.1012651108. Epub 2010 Dec 14.


Plasticity of brain networks in a randomized intervention trial of exercise training in older adults.

Voss MW, Prakash RS, Erickson KI, Basak C, Chaddock L, Kim JS, Alves H, Heo S, Szabo AN, White SM, Wójcicki TR, Mailey EL, Gothe N, Olson EA, McAuley E, Kramer AF.

Front Aging Neurosci. 2010 Aug 26;2. pii: 32. doi: 10.3389/fnagi.2010.00032. eCollection 2010.


Reduced posterior cingulate mitochondrial activity in expired young adult carriers of the APOE ε4 allele, the major late-onset Alzheimer's susceptibility gene.

Valla J, Yaari R, Wolf AB, Kusne Y, Beach TG, Roher AE, Corneveaux JJ, Huentelman MJ, Caselli RJ, Reiman EM.

J Alzheimers Dis. 2010;22(1):307-13. doi: 10.3233/JAD-2010-100129.


Regional aerobic glycolysis in the human brain.

Vaishnavi SN, Vlassenko AG, Rundle MM, Snyder AZ, Mintun MA, Raichle ME.

Proc Natl Acad Sci U S A. 2010 Oct 12;107(41):17757-62. doi: 10.1073/pnas.1010459107. Epub 2010 Sep 13.


Spatial correlation between brain aerobic glycolysis and amyloid-β (Aβ ) deposition.

Vlassenko AG, Vaishnavi SN, Couture L, Sacco D, Shannon BJ, Mach RH, Morris JC, Raichle ME, Mintun MA.

Proc Natl Acad Sci U S A. 2010 Oct 12;107(41):17763-7. doi: 10.1073/pnas.1010461107. Epub 2010 Sep 13.


Exercise and Alzheimer's disease biomarkers in cognitively normal older adults.

Liang KY, Mintun MA, Fagan AM, Goate AM, Bugg JM, Holtzman DM, Morris JC, Head D.

Ann Neurol. 2010 Sep;68(3):311-8. doi: 10.1002/ana.22096.


Larger temporal volume in elderly with high versus low beta-amyloid deposition.

Chételat G, Villemagne VL, Pike KE, Baron JC, Bourgeat P, Jones G, Faux NG, Ellis KA, Salvado O, Szoeke C, Martins RN, Ames D, Masters CL, Rowe CC; Australian Imaging Biomarkers and Lifestyle Study of Ageing (AIBL) Research Group.

Brain. 2010 Nov;133(11):3349-58. doi: 10.1093/brain/awq187. Epub 2010 Aug 25.


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