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Items: 1 to 20 of 72

1.

Insulin infusion during normoglycemia modulates insulin secretion according to whole-body insulin sensitivity.

Anderwald C, Tura A, Grassi A, Krebs M, Szendroedi J, Roden M, Bischof MG, Luger A, Pacini G.

Diabetes Care. 2011 Feb;34(2):437-41. doi: 10.2337/dc10-1137. Epub 2011 Jan 7.

2.

Class IA phosphatidylinositol 3-kinase in pancreatic β cells controls insulin secretion by multiple mechanisms.

Kaneko K, Ueki K, Takahashi N, Hashimoto S, Okamoto M, Awazawa M, Okazaki Y, Ohsugi M, Inabe K, Umehara T, Yoshida M, Kakei M, Kitamura T, Luo J, Kulkarni RN, Kahn CR, Kasai H, Cantley LC, Kadowaki T.

Cell Metab. 2010 Dec 1;12(6):619-32. doi: 10.1016/j.cmet.2010.11.005.

3.

Insulin enhances glucose-stimulated insulin secretion in healthy humans.

Bouche C, Lopez X, Fleischman A, Cypess AM, O'Shea S, Stefanovski D, Bergman RN, Rogatsky E, Stein DT, Kahn CR, Kulkarni RN, Goldfine AB.

Proc Natl Acad Sci U S A. 2010 Mar 9;107(10):4770-5. doi: 10.1073/pnas.1000002107. Epub 2010 Feb 22.

4.

Free fatty acids induce a proinflammatory response in islets via the abundantly expressed interleukin-1 receptor I.

Böni-Schnetzler M, Boller S, Debray S, Bouzakri K, Meier DT, Prazak R, Kerr-Conte J, Pattou F, Ehses JA, Schuit FC, Donath MY.

Endocrinology. 2009 Dec;150(12):5218-29. doi: 10.1210/en.2009-0543. Epub 2009 Oct 9.

PMID:
19819943
5.

Insulin signaling in alpha cells modulates glucagon secretion in vivo.

Kawamori D, Kurpad AJ, Hu J, Liew CW, Shih JL, Ford EL, Herrera PL, Polonsky KS, McGuinness OP, Kulkarni RN.

Cell Metab. 2009 Apr;9(4):350-61. doi: 10.1016/j.cmet.2009.02.007.

6.

Glucose effects on beta-cell growth and survival require activation of insulin receptors and insulin receptor substrate 2.

Assmann A, Ueki K, Winnay JN, Kadowaki T, Kulkarni RN.

Mol Cell Biol. 2009 Jun;29(11):3219-28. doi: 10.1128/MCB.01489-08. Epub 2009 Mar 9.

7.

A beta cell-specific knockout of hormone-sensitive lipase in mice results in hyperglycaemia and disruption of exocytosis.

Fex M, Haemmerle G, Wierup N, Dekker-Nitert M, Rehn M, Ristow M, Zechner R, Sundler F, Holm C, Eliasson L, Mulder H.

Diabetologia. 2009 Feb;52(2):271-80. doi: 10.1007/s00125-008-1191-9. Epub 2008 Nov 21.

PMID:
19023560
8.

GPR40 carboxylic acid receptor family and diabetes: a new drug target.

Telvekar VN, Kundaikar HS.

Curr Drug Targets. 2008 Oct;9(10):899-910. Review.

PMID:
18855625
9.

Growth factor control of pancreatic islet regeneration and function.

Assmann A, Hinault C, Kulkarni RN.

Pediatr Diabetes. 2009 Feb;10(1):14-32. doi: 10.1111/j.1399-5448.2008.00468.x. Epub 2008 Sep 19. Review. No abstract available.

10.

Selective small-molecule agonists of G protein-coupled receptor 40 promote glucose-dependent insulin secretion and reduce blood glucose in mice.

Tan CP, Feng Y, Zhou YP, Eiermann GJ, Petrov A, Zhou C, Lin S, Salituro G, Meinke P, Mosley R, Akiyama TE, Einstein M, Kumar S, Berger JP, Mills SG, Thornberry NA, Yang L, Howard AD.

Diabetes. 2008 Aug;57(8):2211-9. doi: 10.2337/db08-0130. Epub 2008 May 13.

11.

Insulin receptors in beta-cells are critical for islet compensatory growth response to insulin resistance.

Okada T, Liew CW, Hu J, Hinault C, Michael MD, Krtzfeldt J, Yin C, Holzenberger M, Stoffel M, Kulkarni RN.

Proc Natl Acad Sci U S A. 2007 May 22;104(21):8977-82. Epub 2007 Apr 6.

12.

Progressive loss of beta-cell function leads to worsening glucose tolerance in first-degree relatives of subjects with type 2 diabetes.

Cnop M, Vidal J, Hull RL, Utzschneider KM, Carr DB, Schraw T, Scherer PE, Boyko EJ, Fujimoto WY, Kahn SE.

Diabetes Care. 2007 Mar;30(3):677-82.

PMID:
17327340
13.

Effects on insulin secretion and insulin action of a 48-h reduction of plasma free fatty acids with acipimox in nondiabetic subjects genetically predisposed to type 2 diabetes.

Cusi K, Kashyap S, Gastaldelli A, Bajaj M, Cersosimo E.

Am J Physiol Endocrinol Metab. 2007 Jun;292(6):E1775-81. Epub 2007 Feb 13.

14.

Fatty acid signaling in the beta-cell and insulin secretion.

Nolan CJ, Madiraju MS, Delghingaro-Augusto V, Peyot ML, Prentki M.

Diabetes. 2006 Dec;55 Suppl 2:S16-23. Review.

15.

Lipid-induced beta-cell dysfunction in vivo in models of progressive beta-cell failure.

Goh TT, Mason TM, Gupta N, So A, Lam TK, Lam L, Lewis GF, Mari A, Giacca A.

Am J Physiol Endocrinol Metab. 2007 Feb;292(2):E549-60. Epub 2006 Sep 26.

16.

The effect of insulin administration on the insulin content of the pancreas.

Best CH, Haist RE.

J Physiol. 1941 Sep 8;100(2):142-6. No abstract available.

17.

Protection of INS-1 cells from free fatty acid-induced apoptosis by targeting hOGG1 to mitochondria.

Rachek LI, Thornley NP, Grishko VI, LeDoux SP, Wilson GL.

Diabetes. 2006 Apr;55(4):1022-8.

18.

Acute effects of insulin on beta-cells from transplantable human islets.

Luciani DS, Johnson JD.

Mol Cell Endocrinol. 2005 Sep 28;241(1-2):88-98.

PMID:
16099589
19.

Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes.

Gunton JE, Kulkarni RN, Yim S, Okada T, Hawthorne WJ, Tseng YH, Roberson RS, Ricordi C, O'Connell PJ, Gonzalez FJ, Kahn CR.

Cell. 2005 Aug 12;122(3):337-49.

20.

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