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Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis.

Oberst A, Dillon CP, Weinlich R, McCormick LL, Fitzgerald P, Pop C, Hakem R, Salvesen GS, Green DR.

Nature. 2011 Mar 17;471(7338):363-7. doi: 10.1038/nature09852. Epub 2011 Mar 2.


RIP3 mediates the embryonic lethality of caspase-8-deficient mice.

Kaiser WJ, Upton JW, Long AB, Livingston-Rosanoff D, Daley-Bauer LP, Hakem R, Caspary T, Mocarski ES.

Nature. 2011 Mar 17;471(7338):368-72. doi: 10.1038/nature09857. Epub 2011 Mar 2.


Molecular mechanisms of necroptosis: an ordered cellular explosion.

Vandenabeele P, Galluzzi L, Vanden Berghe T, Kroemer G.

Nat Rev Mol Cell Biol. 2010 Oct;11(10):700-14. doi: 10.1038/nrm2970. Epub 2010 Sep 8. Review.


Inflammatory bowel disease.

Kaser A, Zeissig S, Blumberg RS.

Annu Rev Immunol. 2010;28:573-621. doi: 10.1146/annurev-immunol-030409-101225. Review.


Mucosal gene expression of antimicrobial peptides in inflammatory bowel disease before and after first infliximab treatment.

Arijs I, De Hertogh G, Lemaire K, Quintens R, Van Lommel L, Van Steen K, Leemans P, Cleynen I, Van Assche G, Vermeire S, Geboes K, Schuit F, Rutgeerts P.

PLoS One. 2009 Nov 24;4(11):e7984. doi: 10.1371/journal.pone.0007984.


The death effector domains of caspase-8 induce terminal differentiation.

Mielgo A, Torres VA, Schmid MC, Graf R, Zeitlin SG, Lee P, Shields DJ, Barbero S, Jamora C, Stupack DG.

PLoS One. 2009 Nov 18;4(11):e7879. doi: 10.1371/journal.pone.0007879.


RIP kinases at the crossroads of cell death and survival.

Declercq W, Vanden Berghe T, Vandenabeele P.

Cell. 2009 Jul 23;138(2):229-32. doi: 10.1016/j.cell.2009.07.006. Review.


Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation.

Cho YS, Challa S, Moquin D, Genga R, Ray TD, Guildford M, Chan FK.

Cell. 2009 Jun 12;137(6):1112-23. doi: 10.1016/j.cell.2009.05.037.


Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha.

He S, Wang L, Miao L, Wang T, Du F, Zhao L, Wang X.

Cell. 2009 Jun 12;137(6):1100-11. doi: 10.1016/j.cell.2009.05.021.


RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis.

Zhang DW, Shao J, Lin J, Zhang N, Lu BJ, Lin SC, Dong MQ, Han J.

Science. 2009 Jul 17;325(5938):332-6. doi: 10.1126/science.1172308. Epub 2009 Jun 4.


Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche.

Sato T, Vries RG, Snippert HJ, van de Wetering M, Barker N, Stange DE, van Es JH, Abo A, Kujala P, Peters PJ, Clevers H.

Nature. 2009 May 14;459(7244):262-5. doi: 10.1038/nature07935. Epub 2009 Mar 29.


Barrier dysfunction due to distinct defensin deficiencies in small intestinal and colonic Crohn's disease.

Wehkamp J, Koslowski M, Wang G, Stange EF.

Mucosal Immunol. 2008 Nov;1 Suppl 1:S67-74. doi: 10.1038/mi.2008.48. Review.


Death effector domain-containing proteins.

Valmiki MG, Ramos JW.

Cell Mol Life Sci. 2009 Mar;66(5):814-30. doi: 10.1007/s00018-008-8489-0. Review.


Non-apoptotic functions of caspase-8.

Maelfait J, Beyaert R.

Biochem Pharmacol. 2008 Dec 1;76(11):1365-73. doi: 10.1016/j.bcp.2008.07.034. Epub 2008 Aug 6. Review.


Epithelial-cell recognition of commensal bacteria and maintenance of immune homeostasis in the gut.

Artis D.

Nat Rev Immunol. 2008 Jun;8(6):411-20. doi: 10.1038/nri2316. Review.


Identification of RIP1 kinase as a specific cellular target of necrostatins.

Degterev A, Hitomi J, Germscheid M, Ch'en IL, Korkina O, Teng X, Abbott D, Cuny GD, Yuan C, Wagner G, Hedrick SM, Gerber SA, Lugovskoy A, Yuan J.

Nat Chem Biol. 2008 May;4(5):313-21. doi: 10.1038/nchembio.83.


Epithelial NEMO links innate immunity to chronic intestinal inflammation.

Nenci A, Becker C, Wullaert A, Gareus R, van Loo G, Danese S, Huth M, Nikolaev A, Neufert C, Madison B, Gumucio D, Neurath MF, Pasparakis M.

Nature. 2007 Mar 29;446(7135):557-61. Epub 2007 Mar 14.


The fundamental basis of inflammatory bowel disease.

Strober W, Fuss I, Mannon P.

J Clin Invest. 2007 Mar;117(3):514-21. Review.


Paneth cells: their role in innate immunity and inflammatory disease.

Elphick DA, Mahida YR.

Gut. 2005 Dec;54(12):1802-9. Review. No abstract available.


Cutting edge: innate immunity conferred by B cells is regulated by caspase-8.

Beisner DR, Ch'en IL, Kolla RV, Hoffmann A, Hedrick SM.

J Immunol. 2005 Sep 15;175(6):3469-73.

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