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FLT3 expression initiates in fully multipotent mouse hematopoietic progenitor cells.

Buza-Vidas N, Woll P, Hultquist A, Duarte S, Lutteropp M, Bouriez-Jones T, Ferry H, Luc S, Jacobsen SE.

Blood. 2011 Aug 11;118(6):1544-8. doi: 10.1182/blood-2010-10-316232. Epub 2011 May 31.


Defective nonhomologous end joining blocks B-cell development in FLT3/ITD mice.

Li L, Zhang L, Fan J, Greenberg K, Desiderio S, Rassool FV, Small D.

Blood. 2011 Mar 17;117(11):3131-9. doi: 10.1182/blood-2010-05-286070. Epub 2011 Jan 12.


Expression and role of FLT3 in regulation of the earliest stage of normal granulocyte-monocyte progenitor development.

Böiers C, Buza-Vidas N, Jensen CT, Pronk CJ, Kharazi S, Wittmann L, Sitnicka E, Hultquist A, Jacobsen SE.

Blood. 2010 Jun 17;115(24):5061-8. doi: 10.1182/blood-2009-12-258756. Epub 2010 Apr 14.


Copy neutral loss of heterozygosity: a novel chromosomal lesion in myeloid malignancies.

O'Keefe C, McDevitt MA, Maciejewski JP.

Blood. 2010 Apr 8;115(14):2731-9. doi: 10.1182/blood-2009-10-201848. Epub 2010 Jan 27. Review.


Genomic analysis of acute myeloid leukemia: potential for new prognostic indicators.

Eklund EA.

Curr Opin Hematol. 2010 Mar;17(2):75-8. doi: 10.1097/MOH.0b013e3283366c43. Review.


Prognostic factors in AML in relation to (ab)normal karyotype.

Stone RM.

Best Pract Res Clin Haematol. 2009 Dec;22(4):523-8. doi: 10.1016/j.beha.2009.07.003. Review.


Genome-wide profiling of genetic alterations in acute lymphoblastic leukemia: recent insights and future directions.

Mullighan CG, Downing JR.

Leukemia. 2009 Jul;23(7):1209-18. doi: 10.1038/leu.2009.18. Epub 2009 Feb 26. Review.


Anchoring of FLT3 in the endoplasmic reticulum alters signaling quality.

Schmidt-Arras D, Böhmer SA, Koch S, Müller JP, Blei L, Cornils H, Bauer R, Korasikha S, Thiede C, Böhmer FD.

Blood. 2009 Apr 9;113(15):3568-76. doi: 10.1182/blood-2007-10-121426. Epub 2009 Feb 9.


Whole genome scanning as a cytogenetic tool in hematologic malignancies.

Maciejewski JP, Mufti GJ.

Blood. 2008 Aug 15;112(4):965-74. doi: 10.1182/blood-2008-02-130435. Epub 2008 May 27. Review.


Segmental uniparental disomy is a commonly acquired genetic event in relapsed acute myeloid leukemia.

Raghavan M, Smith LL, Lillington DM, Chaplin T, Kakkas I, Molloy G, Chelala C, Cazier JB, Cavenagh JD, Fitzgibbon J, Lister TA, Young BD.

Blood. 2008 Aug 1;112(3):814-21. doi: 10.1182/blood-2008-01-132431. Epub 2008 May 19.


Genomic instability in myeloid malignancies: increased reactive oxygen species (ROS), DNA double strand breaks (DSBs) and error-prone repair.

Sallmyr A, Fan J, Rassool FV.

Cancer Lett. 2008 Oct 18;270(1):1-9. doi: 10.1016/j.canlet.2008.03.036. Epub 2008 May 7. Review.


Reciprocal activation of GATA-1 and PU.1 marks initial specification of hematopoietic stem cells into myeloerythroid and myelolymphoid lineages.

Arinobu Y, Mizuno S, Chong Y, Shigematsu H, Iino T, Iwasaki H, Graf T, Mayfield R, Chan S, Kastner P, Akashi K.

Cell Stem Cell. 2007 Oct 11;1(4):416-27. doi: 10.1016/j.stem.2007.07.004.


Abnormal localization and accumulation of FLT3-ITD, a mutant receptor tyrosine kinase involved in leukemogenesis.

Koch S, Jacobi A, Ryser M, Ehninger G, Thiede C.

Cells Tissues Organs. 2008;188(1-2):225-35. doi: 10.1159/000118788. Epub 2008 Feb 27.


Knock-in of an internal tandem duplication mutation into murine FLT3 confers myeloproliferative disease in a mouse model.

Li L, Piloto O, Nguyen HB, Greenberg K, Takamiya K, Racke F, Huso D, Small D.

Blood. 2008 Apr 1;111(7):3849-58. doi: 10.1182/blood-2007-08-109942. Epub 2008 Feb 1.


Internal tandem duplication of FLT3 (FLT3/ITD) induces increased ROS production, DNA damage, and misrepair: implications for poor prognosis in AML.

Sallmyr A, Fan J, Datta K, Kim KT, Grosu D, Shapiro P, Small D, Rassool F.

Blood. 2008 Mar 15;111(6):3173-82. doi: 10.1182/blood-2007-05-092510. Epub 2008 Jan 11.


The impact of FLT3 internal tandem duplication mutant level, number, size, and interaction with NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemia.

Gale RE, Green C, Allen C, Mead AJ, Burnett AK, Hills RK, Linch DC; Medical Research Council Adult Leukaemia Working Party.

Blood. 2008 Mar 1;111(5):2776-84. Epub 2007 Oct 23.


FLT3 mutations confer enhanced proliferation and survival properties to multipotent progenitors in a murine model of chronic myelomonocytic leukemia.

Lee BH, Tothova Z, Levine RL, Anderson K, Buza-Vidas N, Cullen DE, McDowell EP, Adelsperger J, Fröhling S, Huntly BJ, Beran M, Jacobsen SE, Gilliland DG.

Cancer Cell. 2007 Oct;12(4):367-80.


Myeloid lineage commitment from the hematopoietic stem cell.

Iwasaki H, Akashi K.

Immunity. 2007 Jun;26(6):726-40. Review.


Genome-wide SNP analysis in cancer: leukemia shows the way.

Wang Y, Armstrong SA.

Cancer Cell. 2007 Apr;11(4):308-9. Review.


Block of C/EBP alpha function by phosphorylation in acute myeloid leukemia with FLT3 activating mutations.

Radomska HS, Bassères DS, Zheng R, Zhang P, Dayaram T, Yamamoto Y, Sternberg DW, Lokker N, Giese NA, Bohlander SK, Schnittger S, Delmotte MH, Davis RJ, Small D, Hiddemann W, Gilliland DG, Tenen DG.

J Exp Med. 2006 Feb 20;203(2):371-81. Epub 2006 Jan 30.

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