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Items: 1 to 20 of 73

1.

LUBAC regulates NF-κB activation upon genotoxic stress by promoting linear ubiquitination of NEMO.

Niu J, Shi Y, Iwai K, Wu ZH.

EMBO J. 2011 Aug 2;30(18):3741-53. doi: 10.1038/emboj.2011.264.

2.

New mechanism of X-linked anhidrotic ectodermal dysplasia with immunodeficiency: impairment of ubiquitin binding despite normal folding of NEMO protein.

Hubeau M, Ngadjeua F, Puel A, Israel L, Feinberg J, Chrabieh M, Belani K, Bodemer C, Fabre I, Plebani A, Boisson-Dupuis S, Picard C, Fischer A, Israel A, Abel L, Veron M, Casanova JL, Agou F, Bustamante J.

Blood. 2011 Jul 28;118(4):926-35. doi: 10.1182/blood-2010-10-315234.

3.

Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth.

Wild P, Farhan H, McEwan DG, Wagner S, Rogov VV, Brady NR, Richter B, Korac J, Waidmann O, Choudhary C, Dötsch V, Bumann D, Dikic I.

Science. 2011 Jul 8;333(6039):228-33. doi: 10.1126/science.1205405.

4.

SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis.

Ikeda F, Deribe YL, Skånland SS, Stieglitz B, Grabbe C, Franz-Wachtel M, van Wijk SJ, Goswami P, Nagy V, Terzic J, Tokunaga F, Androulidaki A, Nakagawa T, Pasparakis M, Iwai K, Sundberg JP, Schaefer L, Rittinger K, Macek B, Dikic I.

Nature. 2011 Mar 31;471(7340):637-41. doi: 10.1038/nature09814.

5.

SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex.

Tokunaga F, Nakagawa T, Nakahara M, Saeki Y, Taniguchi M, Sakata S, Tanaka K, Nakano H, Iwai K.

Nature. 2011 Mar 31;471(7340):633-6. doi: 10.1038/nature09815.

PMID:
21455180
6.

Linear ubiquitination prevents inflammation and regulates immune signalling.

Gerlach B, Cordier SM, Schmukle AC, Emmerich CH, Rieser E, Haas TL, Webb AI, Rickard JA, Anderton H, Wong WW, Nachbur U, Gangoda L, Warnken U, Purcell AW, Silke J, Walczak H.

Nature. 2011 Mar 31;471(7340):591-6. doi: 10.1038/nature09816.

PMID:
21455173
7.

The mechanism of linkage-specific ubiquitin chain elongation by a single-subunit E2.

Wickliffe KE, Lorenz S, Wemmer DE, Kuriyan J, Rape M.

Cell. 2011 Mar 4;144(5):769-81. doi: 10.1016/j.cell.2011.01.035.

8.
9.

c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling.

Dynek JN, Goncharov T, Dueber EC, Fedorova AV, Izrael-Tomasevic A, Phu L, Helgason E, Fairbrother WJ, Deshayes K, Kirkpatrick DS, Vucic D.

EMBO J. 2010 Dec 15;29(24):4198-209. doi: 10.1038/emboj.2010.300.

10.

A critical role for the NFkB pathway in multiple myeloma.

Demchenko YN, Kuehl WM.

Oncotarget. 2010 May;1(1):59-68.

11.

A20 inhibition of NFκB and inflammation: targeting E2:E3 ubiquitin enzyme complexes.

Shembade N, Harhaj E.

Cell Cycle. 2010 Jul 1;9(13):2481-2. No abstract available.

12.

Oncogenic activation of NF-kappaB.

Staudt LM.

Cold Spring Harb Perspect Biol. 2010 Jun;2(6):a000109. doi: 10.1101/cshperspect.a000109. Review.

13.

Mutations of optineurin in amyotrophic lateral sclerosis.

Maruyama H, Morino H, Ito H, Izumi Y, Kato H, Watanabe Y, Kinoshita Y, Kamada M, Nodera H, Suzuki H, Komure O, Matsuura S, Kobatake K, Morimoto N, Abe K, Suzuki N, Aoki M, Kawata A, Hirai T, Kato T, Ogasawara K, Hirano A, Takumi T, Kusaka H, Hagiwara K, Kaji R, Kawakami H.

Nature. 2010 May 13;465(7295):223-6. doi: 10.1038/nature08971.

PMID:
20428114
14.

Netrin-1, a missing link between chronic inflammation and tumor progression.

Paradisi A, Mehlen P.

Cell Cycle. 2010 Apr 1;9(7):1253-62.

PMID:
20305387
15.

Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction.

Haas TL, Emmerich CH, Gerlach B, Schmukle AC, Cordier SM, Rieser E, Feltham R, Vince J, Warnken U, Wenger T, Koschny R, Komander D, Silke J, Walczak H.

Mol Cell. 2009 Dec 11;36(5):831-44. doi: 10.1016/j.molcel.2009.10.013.

16.

Detection of sequential polyubiquitylation on a millisecond timescale.

Pierce NW, Kleiger G, Shan SO, Deshaies RJ.

Nature. 2009 Dec 3;462(7273):615-9. doi: 10.1038/nature08595.

17.

Two-sided ubiquitin binding explains specificity of the TAB2 NZF domain.

Kulathu Y, Akutsu M, Bremm A, Hofmann K, Komander D.

Nat Struct Mol Biol. 2009 Dec;16(12):1328-30. doi: 10.1038/nsmb.1731.

PMID:
19935683
18.

A ubiquitin replacement strategy in human cells reveals distinct mechanisms of IKK activation by TNFalpha and IL-1beta.

Xu M, Skaug B, Zeng W, Chen ZJ.

Mol Cell. 2009 Oct 23;36(2):302-14. doi: 10.1016/j.molcel.2009.10.002.

19.

Building ubiquitin chains: E2 enzymes at work.

Ye Y, Rape M.

Nat Rev Mol Cell Biol. 2009 Nov;10(11):755-64. doi: 10.1038/nrm2780. Review.

20.

Crystal structure of the NEMO ubiquitin-binding domain in complex with Lys 63-linked di-ubiquitin.

Yoshikawa A, Sato Y, Yamashita M, Mimura H, Yamagata A, Fukai S.

FEBS Lett. 2009 Oct 20;583(20):3317-22. doi: 10.1016/j.febslet.2009.09.028.

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