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Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages.

Liao W, Lin JX, Wang L, Li P, Leonard WJ.

Nat Immunol. 2011 Jun;12(6):551-9. doi: 10.1038/ni.2030. Epub 2011 Apr 24. Erratum in: Nat Immunol. 2011 Jun;12(6): 2 p following 559.


Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5.

Yang XP, Ghoreschi K, Steward-Tharp SM, Rodriguez-Canales J, Zhu J, Grainger JR, Hirahara K, Sun HW, Wei L, Vahedi G, Kanno Y, O'Shea JJ, Laurence A.

Nat Immunol. 2011 Mar;12(3):247-54. doi: 10.1038/ni.1995. Epub 2011 Jan 30.


Phenotypical and functional specialization of FOXP3+ regulatory T cells.

Campbell DJ, Koch MA.

Nat Rev Immunol. 2011 Feb;11(2):119-30. doi: 10.1038/nri2916. Review.


T-bet represses T(H)17 differentiation by preventing Runx1-mediated activation of the gene encoding RORĪ³t.

Lazarevic V, Chen X, Shim JH, Hwang ES, Jang E, Bolm AN, Oukka M, Kuchroo VK, Glimcher LH.

Nat Immunol. 2011 Jan;12(1):96-104. doi: 10.1038/ni.1969. Epub 2010 Dec 12.


Interleukin-2 receptor signaling: at the interface between tolerance and immunity.

Malek TR, Castro I.

Immunity. 2010 Aug 27;33(2):153-65. doi: 10.1016/j.immuni.2010.08.004. Review.


Th17 and regulatory T cells in mediating and restraining inflammation.

Littman DR, Rudensky AY.

Cell. 2010 Mar 19;140(6):845-58. doi: 10.1016/j.cell.2010.02.021. Review.


Differentiation of effector CD4 T cell populations (*).

Zhu J, Yamane H, Paul WE.

Annu Rev Immunol. 2010;28:445-89. doi: 10.1146/annurev-immunol-030409-101212. Review.


Prolonged interleukin-2Ralpha expression on virus-specific CD8+ T cells favors terminal-effector differentiation in vivo.

Kalia V, Sarkar S, Subramaniam S, Haining WN, Smith KA, Ahmed R.

Immunity. 2010 Jan 29;32(1):91-103. doi: 10.1016/j.immuni.2009.11.010. Epub 2010 Jan 21.


Interleukin-2 and inflammation induce distinct transcriptional programs that promote the differentiation of effector cytolytic T cells.

Pipkin ME, Sacks JA, Cruz-Guilloty F, Lichtenheld MG, Bevan MJ, Rao A.

Immunity. 2010 Jan 29;32(1):79-90. doi: 10.1016/j.immuni.2009.11.012. Epub 2010 Jan 21.


New insights into the regulation of T cells by gamma(c) family cytokines.

Rochman Y, Spolski R, Leonard WJ.

Nat Rev Immunol. 2009 Jul;9(7):480-90. doi: 10.1038/nri2580. Review.


IL-17 and Th17 Cells.

Korn T, Bettelli E, Oukka M, Kuchroo VK.

Annu Rev Immunol. 2009;27:485-517. doi: 10.1146/annurev.immunol.021908.132710. Review.


Priming for T helper type 2 differentiation by interleukin 2-mediated induction of interleukin 4 receptor alpha-chain expression.

Liao W, Schones DE, Oh J, Cui Y, Cui K, Roh TY, Zhao K, Leonard WJ.

Nat Immunol. 2008 Nov;9(11):1288-96. doi: 10.1038/ni.1656. Epub 2008 Sep 28.


CD4 T cells: fates, functions, and faults.

Zhu J, Paul WE.

Blood. 2008 Sep 1;112(5):1557-69. doi: 10.1182/blood-2008-05-078154. Review.


Janus-kinase-3-dependent signals induce chromatin remodeling at the Ifng locus during T helper 1 cell differentiation.

Shi M, Lin TH, Appell KC, Berg LJ.

Immunity. 2008 Jun;28(6):763-73. doi: 10.1016/j.immuni.2008.04.016.


Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction.

Tang Q, Adams JY, Penaranda C, Melli K, Piaggio E, Sgouroudis E, Piccirillo CA, Salomon BL, Bluestone JA.

Immunity. 2008 May;28(5):687-97. doi: 10.1016/j.immuni.2008.03.016. Epub 2008 May 8.


The biology of interleukin-2.

Malek TR.

Annu Rev Immunol. 2008;26:453-79. Review.


TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1.

Amadi-Obi A, Yu CR, Liu X, Mahdi RM, Clarke GL, Nussenblatt RB, Gery I, Lee YS, Egwuagu CE.

Nat Med. 2007 Jun;13(6):711-8. Epub 2007 May 13.


Foxp3 in control of the regulatory T cell lineage.

Zheng Y, Rudensky AY.

Nat Immunol. 2007 May;8(5):457-62. Review.


Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation.

Laurence A, Tato CM, Davidson TS, Kanno Y, Chen Z, Yao Z, Blank RB, Meylan F, Siegel R, Hennighausen L, Shevach EM, O'shea JJ.

Immunity. 2007 Mar;26(3):371-81.


A distal conserved sequence element controls Ifng gene expression by T cells and NK cells.

Hatton RD, Harrington LE, Luther RJ, Wakefield T, Janowski KM, Oliver JR, Lallone RL, Murphy KM, Weaver CT.

Immunity. 2006 Nov;25(5):717-29. Epub 2006 Oct 26.

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