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Items: 1 to 20 of 30

1.

Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies.

International Parkinson Disease Genomics Consortium, Nalls MA, Plagnol V, Hernandez DG, Sharma M, Sheerin UM, Saad M, Simón-Sánchez J, Schulte C, Lesage S, Sveinbjörnsdóttir S, Stefánsson K, Martinez M, Hardy J, Heutink P, Brice A, Gasser T, Singleton AB, Wood NW.

Lancet. 2011 Feb 19;377(9766):641-9. doi: 10.1016/S0140-6736(10)62345-8. Epub 2011 Feb 1.

2.

A map of human genome variation from population-scale sequencing.

1000 Genomes Project Consortium, Abecasis GR, Altshuler D, Auton A, Brooks LD, Durbin RM, Gibbs RA, Hurles ME, McVean GA.

Nature. 2010 Oct 28;467(7319):1061-73. doi: 10.1038/nature09534. Erratum in: Nature. 2011 May 26;473(7348):544. Xue, Yali [added]; Cartwright, Reed A [added]; Altshuler, David L [corrected to Altshuler, David]; Kebbel, Andrew [corrected to Keebler, Jonathan]; Koko-Gonzales, Paula [corrected to Kokko-Gonzales, Paula]; Nickerson, Debbie A [corrected to Nickerson, Deborah A].

3.

Genome-wide significant associations for variants with minor allele frequency of 5% or less--an overview: A HuGE review.

Panagiotou OA, Evangelou E, Ioannidis JP.

Am J Epidemiol. 2010 Oct 15;172(8):869-89. doi: 10.1093/aje/kwq234. Epub 2010 Sep 28. Review.

4.

Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease.

Lee BD, Shin JH, VanKampen J, Petrucelli L, West AB, Ko HS, Lee YI, Maguire-Zeiss KA, Bowers WJ, Federoff HJ, Dawson VL, Dawson TM.

Nat Med. 2010 Sep;16(9):998-1000. doi: 10.1038/nm.2199. Epub 2010 Aug 22.

5.

Novel pathogenic LRRK2 p.Asn1437His substitution in familial Parkinson's disease.

Aasly JO, Vilariño-Güell C, Dachsel JC, Webber PJ, West AB, Haugarvoll K, Johansen KK, Toft M, Nutt JG, Payami H, Kachergus JM, Lincoln SJ, Felic A, Wider C, Soto-Ortolaza AI, Cobb SA, White LR, Ross OA, Farrer MJ.

Mov Disord. 2010 Oct 15;25(13):2156-63. doi: 10.1002/mds.23265.

6.

LRRK2 and Parkinson disease.

Dächsel JC, Farrer MJ.

Arch Neurol. 2010 May;67(5):542-7. doi: 10.1001/archneurol.2010.79. Review.

PMID:
20457952
7.

Challenges in the clinical application of whole-genome sequencing.

Ormond KE, Wheeler MT, Hudgins L, Klein TE, Butte AJ, Altman RB, Ashley EA, Greely HT.

Lancet. 2010 May 15;375(9727):1749-51. doi: 10.1016/S0140-6736(10)60599-5. Epub 2010 Apr 29. No abstract available.

PMID:
20434765
8.

Multiple LRRK2 variants modulate risk of Parkinson disease: a Chinese multicenter study.

Tan EK, Peng R, Teo YY, Tan LC, Angeles D, Ho P, Chen ML, Lin CH, Mao XY, Chang XL, Prakash KM, Liu JJ, Au WL, Le WD, Jankovic J, Burgunder JM, Zhao Y, Wu RM.

Hum Mutat. 2010 May;31(5):561-8. doi: 10.1002/humu.21225.

PMID:
20186690
9.

Population-wide generalizability of genome-wide discovered associations.

Ioannidis JP.

J Natl Cancer Inst. 2009 Oct 7;101(19):1297-9. doi: 10.1093/jnci/djp298. Epub 2009 Sep 2. No abstract available.

PMID:
19726754
10.

Relative contribution of simple mutations vs. copy number variations in five Parkinson disease genes in the Belgian population.

Nuytemans K, Meeus B, Crosiers D, Brouwers N, Goossens D, Engelborghs S, Pals P, Pickut B, Van den Broeck M, Corsmit E, Cras P, De Deyn PP, Del-Favero J, Van Broeckhoven C, Theuns J.

Hum Mutat. 2009 Jul;30(7):1054-61. doi: 10.1002/humu.21007.

PMID:
19405094
11.

Molecular analyses of the LRRK2 gene in European and North African autosomal dominant Parkinson's disease.

Lesage S, Condroyer C, Lannuzel A, Lohmann E, Troiano A, Tison F, Damier P, Thobois S, Ouvrard-Hernandez AM, Rivaud-Péchoux S, Brefel-Courbon C, Destée A, Tranchant C, Romana M, Leclere L, Dürr A, Brice A; French Parkinson's Disease Genetics Study Group.

J Med Genet. 2009 Jul;46(7):458-64. doi: 10.1136/jmg.2008.062612. Epub 2009 Apr 8.

PMID:
19357115
12.

Methods for detecting associations with rare variants for common diseases: application to analysis of sequence data.

Li B, Leal SM.

Am J Hum Genet. 2008 Sep;83(3):311-21. doi: 10.1016/j.ajhg.2008.06.024. Epub 2008 Aug 7.

13.

LRRK2 Gly2019Ser penetrance in Arab-Berber patients from Tunisia: a case-control genetic study.

Hulihan MM, Ishihara-Paul L, Kachergus J, Warren L, Amouri R, Elango R, Prinjha RK, Upmanyu R, Kefi M, Zouari M, Sassi SB, Yahmed SB, El Euch-Fayeche G, Matthews PM, Middleton LT, Gibson RA, Hentati F, Farrer MJ.

Lancet Neurol. 2008 Jul;7(7):591-4. doi: 10.1016/S1474-4422(08)70116-9. Epub 2008 Jun 6. Erratum in: Lancet Neurol. 2008 Aug;7(8):675.

PMID:
18539535
14.

Analysis of Lrrk2 R1628P as a risk factor for Parkinson's disease.

Ross OA, Wu YR, Lee MC, Funayama M, Chen ML, Soto AI, Mata IF, Lee-Chen GJ, Chen CM, Tang M, Zhao Y, Hattori N, Farrer MJ, Tan EK, Wu RM.

Ann Neurol. 2008 Jul;64(1):88-92. doi: 10.1002/ana.21405.

PMID:
18412265
15.

Genome-wide association studies for complex traits: consensus, uncertainty and challenges.

McCarthy MI, Abecasis GR, Cardon LR, Goldstein DB, Little J, Ioannidis JP, Hirschhorn JN.

Nat Rev Genet. 2008 May;9(5):356-69. doi: 10.1038/nrg2344. Review.

PMID:
18398418
16.

Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase.

Deng J, Lewis PA, Greggio E, Sluch E, Beilina A, Cookson MR.

Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1499-504. doi: 10.1073/pnas.0709098105. Epub 2008 Jan 29.

17.

Comprehensive analysis of LRRK2 in publicly available Parkinson's disease cases and neurologically normal controls.

Paisán-Ruíz C, Nath P, Washecka N, Gibbs JR, Singleton AB.

Hum Mutat. 2008 Apr;29(4):485-90. doi: 10.1002/humu.20668.

PMID:
18213618
18.

Neurocirculatory and nigrostriatal abnormalities in Parkinson disease from LRRK2 mutation.

Goldstein DS, Imrich R, Peckham E, Holmes C, Lopez G, Crews C, Hardy J, Singleton A, Hallett M.

Neurology. 2007 Oct 16;69(16):1580-4. Epub 2007 Jul 11.

PMID:
17625107
19.

Lrrk2-associated parkinsonism is a major cause of disease in Northern Spain.

González-Fernández MC, Lezcano E, Ross OA, Gómez-Esteban JC, Gómez-Busto F, Velasco F, Alvarez-Alvarez M, Rodríguez-Martínez MB, Ciordia R, Zarranz JJ, Farrer MJ, Mata IF, de Pancorbo MM.

Parkinsonism Relat Disord. 2007 Dec;13(8):509-15. Epub 2007 May 30.

PMID:
17540608
20.

Lrrk2 G2385R is an ancestral risk factor for Parkinson's disease in Asia.

Farrer MJ, Stone JT, Lin CH, Dächsel JC, Hulihan MM, Haugarvoll K, Ross OA, Wu RM.

Parkinsonism Relat Disord. 2007 Mar;13(2):89-92. Epub 2007 Jan 10.

PMID:
17222580

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