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Items: 1 to 20 of 41

1.

Dialkylamino-2,4-dihydroxybenzoic acids as easily synthesized analogues of platensimycin and platencin with comparable antibacterial properties.

Wang J, Sintim HO.

Chemistry. 2011 Mar 14;17(12):3352-7. doi: 10.1002/chem.201002410. Epub 2011 Feb 14. No abstract available.

PMID:
21322068
2.

The kalimantacin/batumin biosynthesis operon encodes a self-resistance isoform of the FabI bacterial target.

Mattheus W, Masschelein J, Gao LJ, Herdewijn P, Landuyt B, Volckaert G, Lavigne R.

Chem Biol. 2010 Oct 29;17(10):1067-71. doi: 10.1016/j.chembiol.2010.07.015.

3.

Discovery and syntheses of "superbug challengers"-platensimycin and platencin.

Palanichamy K, Kaliappan KP.

Chem Asian J. 2010 Apr 1;5(4):668-703. doi: 10.1002/asia.200900423. Review.

PMID:
20209576
4.

Essentiality of FASII pathway for Staphylococcus aureus.

Balemans W, Lounis N, Gilissen R, Guillemont J, Simmen K, Andries K, Koul A.

Nature. 2010 Jan 21;463(7279):E3; discussion E4. doi: 10.1038/nature08667.

PMID:
20090698
5.

Aquastatin A, a new inhibitor of enoyl-acyl carrier protein reductase from Sporothrix sp. FN611.

Kwon YJ, Fang Y, Xu GH, Kim WG.

Biol Pharm Bull. 2009 Dec;32(12):2061-4.

6.

Waves of resistance: Staphylococcus aureus in the antibiotic era.

Chambers HF, Deleo FR.

Nat Rev Microbiol. 2009 Sep;7(9):629-41. doi: 10.1038/nrmicro2200. Review.

7.

AFN-1252, a FabI inhibitor, demonstrates a Staphylococcus-specific spectrum of activity.

Karlowsky JA, Kaplan N, Hafkin B, Hoban DJ, Zhanel GG.

Antimicrob Agents Chemother. 2009 Aug;53(8):3544-8. doi: 10.1128/AAC.00400-09. Epub 2009 Jun 1.

8.

Acyl-Acyl carrier protein regulates transcription of fatty acid biosynthetic genes via the FabT repressor in Streptococcus pneumoniae.

Jerga A, Rock CO.

J Biol Chem. 2009 Jun 5;284(23):15364-8. doi: 10.1074/jbc.C109.002410. Epub 2009 Apr 17.

9.

Vinaxanthone, a new FabI inhibitor from Penicillium sp.

Zheng CJ, Sohn MJ, Kim WG.

J Antimicrob Chemother. 2009 May;63(5):949-53. doi: 10.1093/jac/dkp058. Epub 2009 Mar 12.

PMID:
19282328
10.

Type II fatty acid synthesis is not a suitable antibiotic target for Gram-positive pathogens.

Brinster S, Lamberet G, Staels B, Trieu-Cuot P, Gruss A, Poyart C.

Nature. 2009 Mar 5;458(7234):83-6. doi: 10.1038/nature07772.

PMID:
19262672
11.

A class of selective antibacterials derived from a protein kinase inhibitor pharmacophore.

Miller JR, Dunham S, Mochalkin I, Banotai C, Bowman M, Buist S, Dunkle B, Hanna D, Harwood HJ, Huband MD, Karnovsky A, Kuhn M, Limberakis C, Liu JY, Mehrens S, Mueller WT, Narasimhan L, Ogden A, Ohren J, Prasad JV, Shelly JA, Skerlos L, Sulavik M, Thomas VH, VanderRoest S, Wang L, Wang Z, Whitton A, Zhu T, Stover CK.

Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):1737-42. doi: 10.1073/pnas.0811275106. Epub 2009 Jan 22.

12.

Novel acyl phosphate mimics that target PlsY, an essential acyltransferase in gram-positive bacteria.

Grimes KD, Lu YJ, Zhang YM, Luna VA, Hurdle JG, Carson EI, Qi J, Kudrimoti S, Rock CO, Lee RE.

ChemMedChem. 2008 Dec;3(12):1936-45. doi: 10.1002/cmdc.200800218.

13.

Membrane lipid homeostasis in bacteria.

Zhang YM, Rock CO.

Nat Rev Microbiol. 2008 Mar;6(3):222-33. doi: 10.1038/nrmicro1839. Review.

PMID:
18264115
14.

Inhibitors of FabI, an enzyme drug target in the bacterial fatty acid biosynthesis pathway.

Lu H, Tonge PJ.

Acc Chem Res. 2008 Jan;41(1):11-20. doi: 10.1021/ar700156e. Review.

PMID:
18193820
15.

Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents.

Bogdanovich T, Clark C, Kosowska-Shick K, Dewasse B, McGhee P, Appelbaum PC.

Antimicrob Agents Chemother. 2007 Nov;51(11):4191-5. Epub 2007 Sep 17.

16.

Cephalochromin, a FabI-directed antibacterial of microbial origin.

Zheng CJ, Sohn MJ, Lee S, Hong YS, Kwak JH, Kim WG.

Biochem Biophys Res Commun. 2007 Nov 3;362(4):1107-12. Epub 2007 Aug 31.

PMID:
17825252
17.

Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties.

Wang J, Kodali S, Lee SH, Galgoci A, Painter R, Dorso K, Racine F, Motyl M, Hernandez L, Tinney E, Colletti SL, Herath K, Cummings R, Salazar O, González I, Basilio A, Vicente F, Genilloud O, Pelaez F, Jayasuriya H, Young K, Cully DF, Singh SB.

Proc Natl Acad Sci U S A. 2007 May 1;104(18):7612-6. Epub 2007 Apr 24.

18.

Lipid A modification systems in gram-negative bacteria.

Raetz CR, Reynolds CM, Trent MS, Bishop RE.

Annu Rev Biochem. 2007;76:295-329. Review.

19.

Organization and function of the YsiA regulon of Bacillus subtilis involved in fatty acid degradation.

Matsuoka H, Hirooka K, Fujita Y.

J Biol Chem. 2007 Feb 23;282(8):5180-94. Epub 2006 Dec 22.

20.

Acyl-phosphates initiate membrane phospholipid synthesis in Gram-positive pathogens.

Lu YJ, Zhang YM, Grimes KD, Qi J, Lee RE, Rock CO.

Mol Cell. 2006 Sep 1;23(5):765-72.

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