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The deacetylase SIRT1 promotes membrane localization and activation of Akt and PDK1 during tumorigenesis and cardiac hypertrophy.

Sundaresan NR, Pillai VB, Wolfgeher D, Samant S, Vasudevan P, Parekh V, Raghuraman H, Cunningham JM, Gupta M, Gupta MP.

Sci Signal. 2011 Jul 19;4(182):ra46. doi: 10.1126/scisignal.2001465.


FOXO3 deficiency leads to increased susceptibility to cigarette smoke-induced inflammation, airspace enlargement, and chronic obstructive pulmonary disease.

Hwang JW, Rajendrasozhan S, Yao H, Chung S, Sundar IK, Huyck HL, Pryhuber GS, Kinnula VL, Rahman I.

J Immunol. 2011 Jul 15;187(2):987-98. doi: 10.4049/jimmunol.1001861.


Preconditioning involves selective mitophagy mediated by Parkin and p62/SQSTM1.

Huang C, Andres AM, Ratliff EP, Hernandez G, Lee P, Gottlieb RA.

PLoS One. 2011;6(6):e20975. doi: 10.1371/journal.pone.0020975.


Efficacy of cardioprotective 'conditioning' strategies in aging and diabetic cohorts: the co-morbidity conundrum.

Przyklenk K.

Drugs Aging. 2011 May 1;28(5):331-43. doi: 10.2165/11587190-000000000-00000. Review.


Monoclonal antibody cocktail as an enrichment tool for acetylome analysis.

Shaw PG, Chaerkady R, Zhang Z, Davidson NE, Pandey A.

Anal Chem. 2011 May 15;83(10):3623-6. doi: 10.1021/ac1026176.


Evidence linking hypoglycemic events to an increased risk of acute cardiovascular events in patients with type 2 diabetes.

Johnston SS, Conner C, Aagren M, Smith DM, Bouchard J, Brett J.

Diabetes Care. 2011 May;34(5):1164-70. doi: 10.2337/dc10-1915.


Is autophagy in response to ischemia and reperfusion protective or detrimental for the heart?

Sciarretta S, Hariharan N, Monden Y, Zablocki D, Sadoshima J.

Pediatr Cardiol. 2011 Mar;32(3):275-81. doi: 10.1007/s00246-010-9855-x.


Silent information regulator 1 protects the heart from ischemia/reperfusion.

Hsu CP, Zhai P, Yamamoto T, Maejima Y, Matsushima S, Hariharan N, Shao D, Takagi H, Oka S, Sadoshima J.

Circulation. 2010 Nov 23;122(21):2170-82. doi: 10.1161/CIRCULATIONAHA.110.958033.


Sirtuin-1 regulation of mammalian metabolism.

Gillum MP, Erion DM, Shulman GI.

Trends Mol Med. 2011 Jan;17(1):8-13. doi: 10.1016/j.molmed.2010.09.005. Review.


Deacetylation of FoxO by Sirt1 Plays an Essential Role in Mediating Starvation-Induced Autophagy in Cardiac Myocytes.

Hariharan N, Maejima Y, Nakae J, Paik J, Depinho RA, Sadoshima J.

Circ Res. 2010 Dec 10;107(12):1470-82. doi: 10.1161/CIRCRESAHA.110.227371.


Lysine deacetylation in ischaemic preconditioning: the role of SIRT1.

Nadtochiy SM, Redman E, Rahman I, Brookes PS.

Cardiovasc Res. 2011 Feb 15;89(3):643-9. doi: 10.1093/cvr/cvq287.


Protein deacetylation by sirtuins: delineating a post-translational regulatory program responsive to nutrient and redox stressors.

Bao J, Sack MN.

Cell Mol Life Sci. 2010 Sep;67(18):3073-87. doi: 10.1007/s00018-010-0402-y. Review.


Nuclear translocation of glyceraldehyde-3-phosphate dehydrogenase is regulated by acetylation.

Ventura M, Mateo F, Serratosa J, Salaet I, Carujo S, Bachs O, Pujol MJ.

Int J Biochem Cell Biol. 2010 Oct;42(10):1672-80. doi: 10.1016/j.biocel.2010.06.014.


Mechanism of cardioprotection by early ischemic preconditioning.

Yang X, Cohen MV, Downey JM.

Cardiovasc Drugs Ther. 2010 Jun;24(3):225-34. doi: 10.1007/s10557-010-6236-x. Review.


Cigarette smoke-induced autophagy is regulated by SIRT1-PARP-1-dependent mechanism: implication in pathogenesis of COPD.

Hwang JW, Chung S, Sundar IK, Yao H, Arunachalam G, McBurney MW, Rahman I.

Arch Biochem Biophys. 2010 Aug 15;500(2):203-9. doi: 10.1016/


Regulation of SIRT1 in cellular functions: role of polyphenols.

Chung S, Yao H, Caito S, Hwang JW, Arunachalam G, Rahman I.

Arch Biochem Biophys. 2010 Sep 1;501(1):79-90. doi: 10.1016/ Review.


Induction of manganese superoxide dismutase by nuclear translocation and activation of SIRT1 promotes cell survival in chronic heart failure.

Tanno M, Kuno A, Yano T, Miura T, Hisahara S, Ishikawa S, Shimamoto K, Horio Y.

J Biol Chem. 2010 Mar 12;285(11):8375-82. doi: 10.1074/jbc.M109.090266.


SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1.

Pacholec M, Bleasdale JE, Chrunyk B, Cunningham D, Flynn D, Garofalo RS, Griffith D, Griffor M, Loulakis P, Pabst B, Qiu X, Stockman B, Thanabal V, Varghese A, Ward J, Withka J, Ahn K.

J Biol Chem. 2010 Mar 12;285(11):8340-51. doi: 10.1074/jbc.M109.088682.


Resveratrol, an activator of SIRT1, upregulates sarcoplasmic calcium ATPase and improves cardiac function in diabetic cardiomyopathy.

Sulaiman M, Matta MJ, Sunderesan NR, Gupta MP, Periasamy M, Gupta M.

Am J Physiol Heart Circ Physiol. 2010 Mar;298(3):H833-43. doi: 10.1152/ajpheart.00418.2009.


The emerging characterization of lysine residue deacetylation on the modulation of mitochondrial function and cardiovascular biology.

Lu Z, Scott I, Webster BR, Sack MN.

Circ Res. 2009 Oct 23;105(9):830-41. doi: 10.1161/CIRCRESAHA.109.204974. Review.

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