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Items: 1 to 20 of 47

1.

Metabolism of P450 probe substrates by cynomolgus monkey CYP2C76.

Uno Y, Matsuno K, Murayama N, Nakamura C, Yamazaki H.

Basic Clin Pharmacol Toxicol. 2011 Oct;109(4):315-8. doi: 10.1111/j.1742-7843.2011.00740.x. No abstract available.

2.

Species differences in intestinal metabolic activities of cytochrome P450 isoforms between cynomolgus monkeys and humans.

Nishimuta H, Sato K, Mizuki Y, Yabuki M, Komuro S.

Drug Metab Pharmacokinet. 2011 Jun;26(3):300-6. doi: 10.2133/dmpk.DMPK-10-SH-119.

3.

Newly identified CYP2C93 is a functional enzyme in rhesus monkey, but not in cynomolgus monkey.

Uno Y, Uehara S, Kohara S, Iwasaki K, Nagata R, Fukuzaki K, Utoh M, Murayama N, Yamazaki H.

PLoS One. 2011 Feb 8;6(2):e16923. doi: 10.1371/journal.pone.0016923.

4.

Macaque cytochromes P450: nomenclature, transcript, gene, genomic structure, and function.

Uno Y, Iwasaki K, Yamazaki H, Nelson DR.

Drug Metab Rev. 2011 Aug;43(3):346-61. doi: 10.3109/03602532.2010.549492. Review.

PMID:
21303270
5.

Regional distribution of drug-metabolizing enzyme activities in the liver and small intestine of cynomolgus monkeys.

Nakanishi Y, Matsushita A, Matsuno K, Iwasaki K, Utoh M, Nakamura C, Uno Y.

Drug Metab Pharmacokinet. 2011 Jun;26(3):288-94. doi: 10.2133/dmpk.DMPK-10-NT-101.

6.

A newly developed DNA microarray is useful to assess induction of cytochromes p450 in the cynomolgus monkey.

Ise R, Uehara S, Akiyama H, Kondo S, Iwasaki K, Nagata R, Nobumasa H, Yamazaki H, Uno Y.

Drug Metab Pharmacokinet. 2011 Jun;26(3):228-35. doi: 10.2133/dmpk.DMPK-10-RG-099.

7.

CYP1D1, pseudogenized in human, is expressed and encodes a functional drug-metabolizing enzyme in cynomolgus monkey.

Uno Y, Uehara S, Murayama N, Yamazaki H.

Biochem Pharmacol. 2011 Feb 1;81(3):442-50. doi: 10.1016/j.bcp.2010.11.003.

PMID:
21070747
8.

A novel CYP2A26 identified in cynomolgus monkey liver metabolizes coumarin.

Uehara S, Murayama N, Yamazaki H, Uno Y.

Xenobiotica. 2010 Sep;40(9):621-9. doi: 10.3109/00498254.2010.501118.

PMID:
20929430
9.

Comparison of cytochrome P450 3A enzymes in cynomolgus monkeys and humans.

Iwasaki K, Murayama N, Koizumi R, Uno Y, Yamazaki H.

Drug Metab Pharmacokinet. 2010;25(4):388-91.

10.

Cynomolgus monkey CYP2D44 newly identified in liver, metabolizes bufuralol, and dextromethorphan.

Uno Y, Uehara S, Kohara S, Murayama N, Yamazaki H.

Drug Metab Dispos. 2010 Sep;38(9):1486-92. doi: 10.1124/dmd.110.033274.

11.

Macaque CYP2C76 encodes cytochrome P450 enzyme not orthologous to any human isozymes.

Uno Y, Fujino H, Iwasaki K, Utoh M.

Curr Drug Metab. 2010 Feb;11(2):142-52. Review.

PMID:
20359284
12.

Identification and characterization of CYP2B6 cDNA in cynomolgus macaques (Macaca fascicularis).

Uno Y, Matsuno K, Nakamura C, Utoh M, Yamazaki H.

J Vet Med Sci. 2009 Dec;71(12):1653-6.

13.

Cloning, expression, and characterization of CYP3A43 cDNA in cynomolgus macaque (Macaca fascicularis).

Uno Y, Matsuno K, Nakamura C, Utoh M, Yamazaki H.

Drug Metab Lett. 2009 Dec;3(4):228-33.

PMID:
20041831
14.

Identification and characterization of CYP2C18 in the cynomolgus macaque (Macaca fascicularis).

Uno Y, Matsuno K, Nakamura C, Utoh M, Yamazaki H.

J Vet Med Sci. 2010 Feb;72(2):225-8.

15.

Genetic variants of CYP3A4 and CYP3A5 in cynomolgus and rhesus macaques.

Uno Y, Matsushita A, Osada N, Uehara S, Kohara S, Nagata R, Fukuzaki K, Utoh M, Murayama N, Yamazaki H.

Drug Metab Dispos. 2010 Feb;38(2):209-14. doi: 10.1124/dmd.109.029710.

16.

Evaluation of cynomolgus monkey pregnane X receptor, primary hepatocyte, and in vivo pharmacokinetic changes in predicting human CYP3A4 induction.

Kim S, Dinchuk JE, Anthony MN, Orcutt T, Zoeckler ME, Sauer MB, Mosure KW, Vuppugalla R, Grace JE Jr, Simmermacher J, Dulac HA, Pizzano J, Sinz M.

Drug Metab Dispos. 2010 Jan;38(1):16-24. doi: 10.1124/dmd.109.029637.

17.

Effects of histidine-tag on recombinant human cytochrome P450 3A5 catalytic activity in reconstitution systems.

Emoto C, Murayama N, Wakiya S, Yamazaki H.

Drug Metab Lett. 2009 Dec;3(4):207-11.

PMID:
19702542
18.

A null allele impairs function of CYP2C76 gene in cynomolgus monkeys: a possible genetic tool for generation of a better animal model in drug metabolism.

Uno Y, Sakuraba H, Uehara S, Kumano T, Matsuno K, Nakamura C, Kito G, Kamataki T, Nagata R.

Drug Metab Dispos. 2009 Jan;37(1):14-7. doi: 10.1124/dmd.108.023622.

19.

Predictive value of animal models for human cytochrome P450 (CYP)-mediated metabolism: a comparative study in vitro.

Turpeinen M, Ghiciuc C, Opritoui M, Tursas L, Pelkonen O, Pasanen M.

Xenobiotica. 2007 Dec;37(12):1367-77.

PMID:
17943662
20.

Characterization of cynomolgus monkey cytochrome P450 (CYP) cDNAs: is CYP2C76 the only monkey-specific CYP gene responsible for species differences in drug metabolism?

Uno Y, Hosaka S, Matsuno K, Nakamura C, Kito G, Kamataki T, Nagata R.

Arch Biochem Biophys. 2007 Oct 1;466(1):98-105.

PMID:
17689485
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