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Items: 1 to 20 of 22

1.

A single tyrosine residue in the amyloid precursor protein intracellular domain is essential for developmental function.

Barbagallo AP, Wang Z, Zheng H, D'Adamio L.

J Biol Chem. 2011 Mar 18;286(11):8717-21. doi: 10.1074/jbc.C111.219873.

2.

Tyr(682) in the intracellular domain of APP regulates amyloidogenic APP processing in vivo.

Barbagallo AP, Weldon R, Tamayev R, Zhou D, Giliberto L, Foreman O, D'Adamio L.

PLoS One. 2010 Nov 16;5(11):e15503. doi: 10.1371/journal.pone.0015503.

3.

Genetic dissection of the amyloid precursor protein in developmental function and amyloid pathogenesis.

Li H, Wang Z, Wang B, Guo Q, Dolios G, Tabuchi K, Hammer RE, Südhof TC, Wang R, Zheng H.

J Biol Chem. 2010 Oct 1;285(40):30598-605. doi: 10.1074/jbc.M110.137729.

4.

The interactome of the amyloid beta precursor protein family members is shaped by phosphorylation of their intracellular domains.

Tamayev R, Zhou D, D'Adamio L.

Mol Neurodegener. 2009 Jul 14;4:28. doi: 10.1186/1750-1326-4-28.

5.

Tyrosine kinase nerve growth factor receptor switches from prosurvival to proapoptotic activity via Abeta-mediated phosphorylation.

Matrone C, Marolda R, Ciafrè S, Ciotti MT, Mercanti D, Calissano P.

Proc Natl Acad Sci U S A. 2009 Jul 7;106(27):11358-63. doi: 10.1073/pnas.0904998106.

6.

APP binds DR6 to trigger axon pruning and neuron death via distinct caspases.

Nikolaev A, McLaughlin T, O'Leary DD, Tessier-Lavigne M.

Nature. 2009 Feb 19;457(7232):981-9. doi: 10.1038/nature07767.

7.

Phosphorylation of a tyrosine in the amyloid-beta protein precursor intracellular domain inhibits Fe65 binding and signaling.

Zhou D, Zambrano N, Russo T, D'Adamio L.

J Alzheimers Dis. 2009;16(2):301-7. doi: 10.3233/JAD-2009-0970.

PMID:
19221419
8.

Evidence that the Amyloid beta Precursor Protein-intracellular domain lowers the stress threshold of neurons and has a "regulated" transcriptional role.

Giliberto L, Zhou D, Weldon R, Tamagno E, De Luca P, Tabaton M, D'Adamio L.

Mol Neurodegener. 2008 Sep 2;3:12. doi: 10.1186/1750-1326-3-12.

9.

NGF and BDNF signaling control amyloidogenic route and Abeta production in hippocampal neurons.

Matrone C, Ciotti MT, Mercanti D, Marolda R, Calissano P.

Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):13139-44. doi: 10.1073/pnas.0806133105.

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13.

Generation of an apoptotic intracellular peptide by gamma-secretase cleavage of Alzheimer's amyloid beta protein precursor.

Passer B, Pellegrini L, Russo C, Siegel RM, Lenardo MJ, Schettini G, Bachmann M, Tabaton M, D'Adamio L.

J Alzheimers Dis. 2000 Nov;2(3-4):289-301.

PMID:
12214090
14.

Evidence for a role of the nerve growth factor receptor TrkA in tyrosine phosphorylation and processing of beta-APP.

Tarr PE, Contursi C, Roncarati R, Noviello C, Ghersi E, Scheinfeld MH, Zambrano N, Russo T, D'Adamio L.

Biochem Biophys Res Commun. 2002 Jul 12;295(2):324-9.

PMID:
12150951
15.

Deciphering the genetic basis of Alzheimer's disease.

Selkoe DJ, Podlisny MB.

Annu Rev Genomics Hum Genet. 2002;3:67-99. Review.

PMID:
12142353
16.

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics.

Hardy J, Selkoe DJ.

Science. 2002 Jul 19;297(5580):353-6. Review. Erratum in: Science 2002 Sep 27;297(5590):2209.

PMID:
12130773
18.

A short cytoplasmic domain of the amyloid precursor protein induces apoptosis in vitro and in vivo.

Bertrand E, Brouillet E, Caillé I, Bouillot C, Cole GM, Prochiantz A, Allinquant B.

Mol Cell Neurosci. 2001 Nov;18(5):503-11.

PMID:
11922141
19.

Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc.

Tarr PE, Roncarati R, Pelicci G, Pelicci PG, D'Adamio L.

J Biol Chem. 2002 May 10;277(19):16798-804.

20.

The beta-amyloid precursor protein APP is tyrosine-phosphorylated in cells expressing a constitutively active form of the Abl protoncogene.

Zambrano N, Bruni P, Minopoli G, Mosca R, Molino D, Russo C, Schettini G, Sudol M, Russo T.

J Biol Chem. 2001 Jun 8;276(23):19787-92.

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