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Regulation of adaptive immunity by the innate immune system.

Iwasaki A, Medzhitov R.

Science. 2010 Jan 15;327(5963):291-5. doi: 10.1126/science.1183021. Review.


RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway.

Chiu YH, Macmillan JB, Chen ZJ.

Cell. 2009 Aug 7;138(3):576-91. doi: 10.1016/j.cell.2009.06.015. Epub 2009 Jul 23.


Innate immune sensing of modified vaccinia virus Ankara (MVA) is mediated by TLR2-TLR6, MDA-5 and the NALP3 inflammasome.

Delaloye J, Roger T, Steiner-Tardivel QG, Le Roy D, Knaup Reymond M, Akira S, Petrilli V, Gomez CE, Perdiguero B, Tschopp J, Pantaleo G, Esteban M, Calandra T.

PLoS Pathog. 2009 Jun;5(6):e1000480. doi: 10.1371/journal.ppat.1000480. Epub 2009 Jun 19.


Vaccinia virus subverts a mitochondrial antiviral signaling protein-dependent innate immune response in keratinocytes through its double-stranded RNA binding protein, E3.

Deng L, Dai P, Parikh T, Cao H, Bhoj V, Sun Q, Chen Z, Merghoub T, Houghton A, Shuman S.

J Virol. 2008 Nov;82(21):10735-46. doi: 10.1128/JVI.01305-08. Epub 2008 Aug 20.


RIG-I mediates the co-induction of tumor necrosis factor and type I interferon elicited by myxoma virus in primary human macrophages.

Wang F, Gao X, Barrett JW, Shao Q, Bartee E, Mohamed MR, Rahman M, Werden S, Irvine T, Cao J, Dekaban GA, McFadden G.

PLoS Pathog. 2008 Jul 11;4(7):e1000099. doi: 10.1371/journal.ppat.1000099.


Cutting edge: Overlapping functions of TLR7 and TLR9 for innate defense against a herpesvirus infection.

Zucchini N, Bessou G, Traub S, Robbins SH, Uematsu S, Akira S, Alexopoulou L, Dalod M.

J Immunol. 2008 May 1;180(9):5799-803.


Survival of lethal poxvirus infection in mice depends on TLR9, and therapeutic vaccination provides protection.

Samuelsson C, Hausmann J, Lauterbach H, Schmidt M, Akira S, Wagner H, Chaplin P, Suter M, O'Keeffe M, Hochrein H.

J Clin Invest. 2008 May;118(5):1776-84. doi: 10.1172/JCI33940.


Functional characterization of murine interferon regulatory factor 5 (IRF-5) and its role in the innate antiviral response.

Paun A, Reinert JT, Jiang Z, Medin C, Balkhi MY, Fitzgerald KA, Pitha PM.

J Biol Chem. 2008 May 23;283(21):14295-308. doi: 10.1074/jbc.M800501200. Epub 2008 Mar 10.


Role of IFN regulatory factor 5 transcription factor in antiviral immunity and tumor suppression.

Yanai H, Chen HM, Inuzuka T, Kondo S, Mak TW, Takaoka A, Honda K, Taniguchi T.

Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3402-7. Epub 2007 Feb 20.


Autophagy-dependent viral recognition by plasmacytoid dendritic cells.

Lee HK, Lund JM, Ramanathan B, Mizushima N, Iwasaki A.

Science. 2007 Mar 9;315(5817):1398-401. Epub 2007 Feb 1.


Vaccinia virus entry into cells via a low-pH-dependent endosomal pathway.

Townsley AC, Weisberg AS, Wagenaar TR, Moss B.

J Virol. 2006 Sep;80(18):8899-908.


The specific and essential role of MAVS in antiviral innate immune responses.

Sun Q, Sun L, Liu HH, Chen X, Seth RB, Forman J, Chen ZJ.

Immunity. 2006 May;24(5):633-42.


Innate immune recognition of viral infection.

Kawai T, Akira S.

Nat Immunol. 2006 Feb;7(2):131-7. Review.


Recognition of cytosolic DNA activates an IRF3-dependent innate immune response.

Stetson DB, Medzhitov R.

Immunity. 2006 Jan;24(1):93-103.


Poxvirus multiprotein entry-fusion complex.

Senkevich TG, Ojeda S, Townsley A, Nelson GE, Moss B.

Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18572-7. Epub 2005 Dec 8.


A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA.

Ishii KJ, Coban C, Kato H, Takahashi K, Torii Y, Takeshita F, Ludwig H, Sutter G, Suzuki K, Hemmi H, Sato S, Yamamoto M, Uematsu S, Kawai T, Takeuchi O, Akira S.

Nat Immunol. 2006 Jan;7(1):40-8. Epub 2005 Nov 13. Erratum in: Nat Immunol. 2006 Apr;7(4):427.


A type I interferon autocrine-paracrine loop is involved in Toll-like receptor-induced interleukin-12p70 secretion by dendritic cells.

Gautier G, Humbert M, Deauvieau F, Scuiller M, Hiscott J, Bates EE, Trinchieri G, Caux C, Garrone P.

J Exp Med. 2005 May 2;201(9):1435-46. Epub 2005 Apr 25.


Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction.

Honda K, Ohba Y, Yanai H, Negishi H, Mizutani T, Takaoka A, Taya C, Taniguchi T.

Nature. 2005 Apr 21;434(7036):1035-40. Epub 2005 Apr 6.


IRF-7 is the master regulator of type-I interferon-dependent immune responses.

Honda K, Yanai H, Negishi H, Asagiri M, Sato M, Mizutani T, Shimada N, Ohba Y, Takaoka A, Yoshida N, Taniguchi T.

Nature. 2005 Apr 7;434(7034):772-7. Epub 2005 Mar 30.

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