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Items: 1 to 20 of 38

1.

The NCGC pharmaceutical collection: a comprehensive resource of clinically approved drugs enabling repurposing and chemical genomics.

Huang R, Southall N, Wang Y, Yasgar A, Shinn P, Jadhav A, Nguyen DT, Austin CP.

Sci Transl Med. 2011 Apr 27;3(80):80ps16. doi: 10.1126/scitranslmed.3001862.

2.

Association between the pfmdr1 gene and in vitro artemether and lumefantrine sensitivity in Thai isolates of Plasmodium falciparum.

Mungthin M, Khositnithikul R, Sitthichot N, Suwandittakul N, Wattanaveeradej V, Ward SA, Na-Bangchang K.

Am J Trop Med Hyg. 2010 Nov;83(5):1005-9. doi: 10.4269/ajtmh.2010.10-0339.

3.

Spiroindolones, a potent compound class for the treatment of malaria.

Rottmann M, McNamara C, Yeung BK, Lee MC, Zou B, Russell B, Seitz P, Plouffe DM, Dharia NV, Tan J, Cohen SB, Spencer KR, González-Páez GE, Lakshminarayana SB, Goh A, Suwanarusk R, Jegla T, Schmitt EK, Beck HP, Brun R, Nosten F, Renia L, Dartois V, Keller TH, Fidock DA, Winzeler EA, Diagana TT.

Science. 2010 Sep 3;329(5996):1175-80. doi: 10.1126/science.1193225.

4.

Chloroquine susceptibility and reversibility in a Plasmodium falciparum genetic cross.

Patel JJ, Thacker D, Tan JC, Pleeter P, Checkley L, Gonzales JM, Deng B, Roepe PD, Cooper RA, Ferdig MT.

Mol Microbiol. 2010 Nov;78(3):770-87. doi: 10.1111/j.1365-2958.2010.07366.x. Epub 2010 Sep 29.

5.

Synthesis, structure-activity relationship, and mode-of-action studies of antimalarial reversed chloroquine compounds.

Burgess SJ, Kelly JX, Shomloo S, Wittlin S, Brun R, Liebmann K, Peyton DH.

J Med Chem. 2010 Sep 9;53(17):6477-89. doi: 10.1021/jm1006484.

6.

Chemical genetics of Plasmodium falciparum.

Guiguemde WA, Shelat AA, Bouck D, Duffy S, Crowther GJ, Davis PH, Smithson DC, Connelly M, Clark J, Zhu F, Jiménez-Díaz MB, Martinez MS, Wilson EB, Tripathi AK, Gut J, Sharlow ER, Bathurst I, El Mazouni F, Fowble JW, Forquer I, McGinley PL, Castro S, Angulo-Barturen I, Ferrer S, Rosenthal PJ, Derisi JL, Sullivan DJ, Lazo JS, Roos DS, Riscoe MK, Phillips MA, Rathod PK, Van Voorhis WC, Avery VM, Guy RK.

Nature. 2010 May 20;465(7296):311-5. doi: 10.1038/nature09099.

7.

Thousands of chemical starting points for antimalarial lead identification.

Gamo FJ, Sanz LM, Vidal J, de Cozar C, Alvarez E, Lavandera JL, Vanderwall DE, Green DV, Kumar V, Hasan S, Brown JR, Peishoff CE, Cardon LR, Garcia-Bustos JF.

Nature. 2010 May 20;465(7296):305-10. doi: 10.1038/nature09107.

PMID:
20485427
8.

Plasmodium falciparum genome-wide scans for positive selection, recombination hot spots and resistance to antimalarial drugs.

Mu J, Myers RA, Jiang H, Liu S, Ricklefs S, Waisberg M, Chotivanich K, Wilairatana P, Krudsood S, White NJ, Udomsangpetch R, Cui L, Ho M, Ou F, Li H, Song J, Li G, Wang X, Seila S, Sokunthea S, Socheat D, Sturdevant DE, Porcella SF, Fairhurst RM, Wellems TE, Awadalla P, Su XZ.

Nat Genet. 2010 Mar;42(3):268-71. doi: 10.1038/ng.528. Epub 2010 Jan 31.

9.

Geographic patterns of Plasmodium falciparum drug resistance distinguished by differential responses to amodiaquine and chloroquine.

Sá JM, Twu O, Hayton K, Reyes S, Fay MP, Ringwald P, Wellems TE.

Proc Natl Acad Sci U S A. 2009 Nov 10;106(45):18883-9. doi: 10.1073/pnas.0911317106. Epub 2009 Nov 2.

10.

Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Yuan J, Johnson RL, Huang R, Wichterman J, Jiang H, Hayton K, Fidock DA, Wellems TE, Inglese J, Austin CP, Su XZ.

Nat Chem Biol. 2009 Oct;5(10):765-71. doi: 10.1038/nchembio.215. Epub 2009 Sep 6.

11.

Varying efficacy of artesunate+amodiaquine and artesunate+sulphadoxine-pyrimethamine for the treatment of uncomplicated falciparum malaria in the Democratic Republic of Congo: a report of two in-vivo studies.

Bonnet M, Broek Iv, van Herp M, Urrutia PP, van Overmeir C, Kyomuhendo J, Ndosimao CN, Ashley E, Guthmann JP.

Malar J. 2009 Aug 10;8:192. doi: 10.1186/1475-2875-8-192.

12.

Artemisinin resistance in Plasmodium falciparum malaria.

Dondorp AM, Nosten F, Yi P, Das D, Phyo AP, Tarning J, Lwin KM, Ariey F, Hanpithakpong W, Lee SJ, Ringwald P, Silamut K, Imwong M, Chotivanich K, Lim P, Herdman T, An SS, Yeung S, Singhasivanon P, Day NP, Lindegardh N, Socheat D, White NJ.

N Engl J Med. 2009 Jul 30;361(5):455-67. doi: 10.1056/NEJMoa0808859. Erratum in: N Engl J Med. 2009 Oct 22;361(17):1714.

13.

Evidence of artemisinin-resistant malaria in western Cambodia.

Noedl H, Se Y, Schaecher K, Smith BL, Socheat D, Fukuda MM; Artemisinin Resistance in Cambodia 1 (ARC1) Study Consortium.

N Engl J Med. 2008 Dec 11;359(24):2619-20. doi: 10.1056/NEJMc0805011. Epub 2008 Dec 8. No abstract available.

14.

Drug resistance and genetic mapping in Plasmodium falciparum.

Hayton K, Su XZ.

Curr Genet. 2008 Nov;54(5):223-39. doi: 10.1007/s00294-008-0214-x. Epub 2008 Sep 18. Review.

PMID:
18802698
15.

Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility.

Kato N, Sakata T, Breton G, Le Roch KG, Nagle A, Andersen C, Bursulaya B, Henson K, Johnson J, Kumar KA, Marr F, Mason D, McNamara C, Plouffe D, Ramachandran V, Spooner M, Tuntland T, Zhou Y, Peters EC, Chatterjee A, Schultz PG, Ward GE, Gray N, Harper J, Winzeler EA.

Nat Chem Biol. 2008 Jun;4(6):347-56. doi: 10.1038/nchembio.87. Epub 2008 May 4.

PMID:
18454143
16.

Qinghaosu (artemisinin): the price of success.

White NJ.

Science. 2008 Apr 18;320(5874):330-4. doi: 10.1126/science.1155165. Review.

PMID:
18420924
17.

Characterization of diversity in toxicity mechanism using in vitro cytotoxicity assays in quantitative high throughput screening.

Huang R, Southall N, Cho MH, Xia M, Inglese J, Austin CP.

Chem Res Toxicol. 2008 Mar;21(3):659-67. doi: 10.1021/tx700365e. Epub 2008 Feb 19.

18.

Additive effects of ciprofloxacin on the in-vitro activity of chloroquine against a clinical isolate of Plasmodium falciparum.

Kazzim OJ, Adegbolagun OM, Osho O, Anumudu CI.

Ann Trop Med Parasitol. 2006 Oct;100(7):579-84.

PMID:
16989683
19.

Searching for new antimalarial therapeutics amongst known drugs.

Weisman JL, Liou AP, Shelat AA, Cohen FE, Guy RK, DeRisi JL.

Chem Biol Drug Des. 2006 Jun;67(6):409-16.

20.

Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries.

Inglese J, Auld DS, Jadhav A, Johnson RL, Simeonov A, Yasgar A, Zheng W, Austin CP.

Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11473-8. Epub 2006 Jul 24.

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