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ClpX(P) generates mechanical force to unfold and translocate its protein substrates.

Maillard RA, Chistol G, Sen M, Righini M, Tan J, Kaiser CM, Hodges C, Martin A, Bustamante C.

Cell. 2011 Apr 29;145(3):459-69. doi: 10.1016/j.cell.2011.04.010.


Single-molecule protein unfolding and translocation by an ATP-fueled proteolytic machine.

Aubin-Tam ME, Olivares AO, Sauer RT, Baker TA, Lang MJ.

Cell. 2011 Apr 15;145(2):257-67. doi: 10.1016/j.cell.2011.03.036.


Structure and mechanism of the hexameric MecA-ClpC molecular machine.

Wang F, Mei Z, Qi Y, Yan C, Hu Q, Wang J, Shi Y.

Nature. 2011 Mar 17;471(7338):331-5. doi: 10.1038/nature09780. Epub 2011 Mar 2.


Rad23 escapes degradation because it lacks a proteasome initiation region.

Fishbain S, Prakash S, Herrig A, Elsasser S, Matouschek A.

Nat Commun. 2011 Feb 8;2:192. doi: 10.1038/ncomms1194.


C-terminal UBA domains protect ubiquitin receptors by preventing initiation of protein degradation.

Heinen C, Acs K, Hoogstraten D, Dantuma NP.

Nat Commun. 2011 Feb 8;2:191. doi: 10.1038/ncomms1179.


Defining the geometry of the two-component proteasome degron.

Inobe T, Fishbain S, Prakash S, Matouschek A.

Nat Chem Biol. 2011 Mar;7(3):161-7. doi: 10.1038/nchembio.521. Epub 2011 Jan 30.


The ubiquitin ligase Hul5 promotes proteasomal processivity.

Aviram S, Kornitzer D.

Mol Cell Biol. 2010 Feb;30(4):985-94. doi: 10.1128/MCB.00909-09. Epub 2009 Dec 14.


Degradation of some polyubiquitinated proteins requires an intrinsic proteasomal binding element in the substrates.

Zhao M, Zhang NY, Zurawel A, Hansen KC, Liu CW.

J Biol Chem. 2010 Feb 12;285(7):4771-80. doi: 10.1074/jbc.M109.060095. Epub 2009 Dec 10.


Multiple Ser/Thr-rich degrons mediate the degradation of Ci/Gli by the Cul3-HIB/SPOP E3 ubiquitin ligase.

Zhang Q, Shi Q, Chen Y, Yue T, Li S, Wang B, Jiang J.

Proc Natl Acad Sci U S A. 2009 Dec 15;106(50):21191-6. doi: 10.1073/pnas.0912008106. Epub 2009 Dec 2.


Targeting proteins for degradation.

Schrader EK, Harstad KG, Matouschek A.

Nat Chem Biol. 2009 Nov;5(11):815-22. doi: 10.1038/nchembio.250. Review. Erratum in: Nat Chem Biol. 2009 Dec;5(12):954.


Recognition and processing of ubiquitin-protein conjugates by the proteasome.

Finley D.

Annu Rev Biochem. 2009;78:477-513. doi: 10.1146/annurev.biochem.78.081507.101607. Review.


ATP-dependent proteases differ substantially in their ability to unfold globular proteins.

Koodathingal P, Jaffe NE, Kraut DA, Prakash S, Fishbain S, Herman C, Matouschek A.

J Biol Chem. 2009 Jul 10;284(28):18674-84. doi: 10.1074/jbc.M900783200. Epub 2009 Apr 21.


Substrate selection by the proteasome during degradation of protein complexes.

Prakash S, Inobe T, Hatch AJ, Matouschek A.

Nat Chem Biol. 2009 Jan;5(1):29-36. doi: 10.1038/nchembio.130. Epub 2008 Nov 23.


Pore loops of the AAA+ ClpX machine grip substrates to drive translocation and unfolding.

Martin A, Baker TA, Sauer RT.

Nat Struct Mol Biol. 2008 Nov;15(11):1147-51. doi: 10.1038/nsmb.1503. Epub 2008 Oct 19.


Protein targeting to ATP-dependent proteases.

Inobe T, Matouschek A.

Curr Opin Struct Biol. 2008 Feb;18(1):43-51. doi: 10.1016/ Epub 2008 Feb 13. Review.


Folding and unfolding mechanism of highly stable full-consensus ankyrin repeat proteins.

Wetzel SK, Settanni G, Kenig M, Binz HK, Pl├╝ckthun A.

J Mol Biol. 2008 Feb 8;376(1):241-57. doi: 10.1016/j.jmb.2007.11.046. Epub 2007 Nov 22.


Rational design, structural and thermodynamic characterization of a hyperstable variant of the villin headpiece helical subdomain.

Bi Y, Cho JH, Kim EY, Shan B, Schindelin H, Raleigh DP.

Biochemistry. 2007 Jun 26;46(25):7497-505. Epub 2007 May 31.


Ubiquitin chains are remodeled at the proteasome by opposing ubiquitin ligase and deubiquitinating activities.

Crosas B, Hanna J, Kirkpatrick DS, Zhang DP, Tone Y, Hathaway NA, Buecker C, Leggett DS, Schmidt M, King RW, Gygi SP, Finley D.

Cell. 2006 Dec 29;127(7):1401-13.


Regulation of Hh/Gli signaling by dual ubiquitin pathways.

Jiang J.

Cell Cycle. 2006 Nov 1;5(21):2457-63. Epub 2006 Sep 14. Review.


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