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Items: 1 to 20 of 40

1.

Prion protein is reduced in aging and in sporadic but not in familial Alzheimer's disease.

Whitehouse IJ, Jackson C, Turner AJ, Hooper NM.

J Alzheimers Dis. 2010;22(3):1023-31. doi: 10.3233/JAD-2010-101071.

PMID:
20930299
2.

Prion protein and Abeta-related synaptic toxicity impairment.

Calella AM, Farinelli M, Nuvolone M, Mirante O, Moos R, Falsig J, Mansuy IM, Aguzzi A.

EMBO Mol Med. 2010 Aug;2(8):306-14. doi: 10.1002/emmm.201000082.

3.

Memory impairment in transgenic Alzheimer mice requires cellular prion protein.

Gimbel DA, Nygaard HB, Coffey EE, Gunther EC, Laurén J, Gimbel ZA, Strittmatter SM.

J Neurosci. 2010 May 5;30(18):6367-74. doi: 10.1523/JNEUROSCI.0395-10.2010.

4.

beta-Secretase inhibitor potency is decreased by aberrant beta-cleavage location of the "Swedish mutant" amyloid precursor protein.

Yamakawa H, Yagishita S, Futai E, Ishiura S.

J Biol Chem. 2010 Jan 15;285(3):1634-42. doi: 10.1074/jbc.M109.066753.

5.

The beta-secretase enzyme BACE in health and Alzheimer's disease: regulation, cell biology, function, and therapeutic potential.

Vassar R, Kovacs DM, Yan R, Wong PC.

J Neurosci. 2009 Oct 14;29(41):12787-94. doi: 10.1523/JNEUROSCI.3657-09.2009. Review.

6.

Relevance of transgenic mouse models to human Alzheimer disease.

Morrissette DA, Parachikova A, Green KN, LaFerla FM.

J Biol Chem. 2009 Mar 6;284(10):6033-7. doi: 10.1074/jbc.R800030200. Review.

7.

The role of amyloid precursor protein processing by BACE1, the beta-secretase, in Alzheimer disease pathophysiology.

Cole SL, Vassar R.

J Biol Chem. 2008 Oct 31;283(44):29621-5. doi: 10.1074/jbc.R800015200. Review.

8.

A new take on prions: preventing Alzheimer's disease.

Hooper NM, Turner AJ.

Trends Biochem Sci. 2008 Apr;33(4):151-5. doi: 10.1016/j.tibs.2008.01.004.

PMID:
18343669
9.

The Alzheimer's disease beta-secretase enzyme, BACE1.

Cole SL, Vassar R.

Mol Neurodegener. 2007 Nov 15;2:22.

10.

Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers.

Kayed R, Head E, Sarsoza F, Saing T, Cotman CW, Necula M, Margol L, Wu J, Breydo L, Thompson JL, Rasool S, Gurlo T, Butler P, Glabe CG.

Mol Neurodegener. 2007 Sep 26;2:18.

11.

Cellular prion protein regulates beta-secretase cleavage of the Alzheimer's amyloid precursor protein.

Parkin ET, Watt NT, Hussain I, Eckman EA, Eckman CB, Manson JC, Baybutt HN, Turner AJ, Hooper NM.

Proc Natl Acad Sci U S A. 2007 Jun 26;104(26):11062-7.

12.

Beta-site amyloid precursor protein cleaving enzyme 1 levels become elevated in neurons around amyloid plaques: implications for Alzheimer's disease pathogenesis.

Zhao J, Fu Y, Yasvoina M, Shao P, Hitt B, O'Connor T, Logan S, Maus E, Citron M, Berry R, Binder L, Vassar R.

J Neurosci. 2007 Apr 4;27(14):3639-49.

13.

Accumulation of prion protein in the brain that is not associated with transmissible disease.

Piccardo P, Manson JC, King D, Ghetti B, Barron RM.

Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4712-7.

14.

A beta oligomers - a decade of discovery.

Walsh DM, Selkoe DJ.

J Neurochem. 2007 Jun;101(5):1172-84. Review.

16.

Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme.

Spoelgen R, von Arnim CA, Thomas AV, Peltan ID, Koker M, Deng A, Irizarry MC, Andersen OM, Willnow TE, Hyman BT.

J Neurosci. 2006 Jan 11;26(2):418-28.

17.

Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein.

Andersen OM, Reiche J, Schmidt V, Gotthardt M, Spoelgen R, Behlke J, von Arnim CA, Breiderhoff T, Jansen P, Wu X, Bales KR, Cappai R, Masters CL, Gliemann J, Mufson EJ, Hyman BT, Paul SM, Nykjaer A, Willnow TE.

Proc Natl Acad Sci U S A. 2005 Sep 20;102(38):13461-6.

18.

Proteolytic mechanisms in amyloid-beta metabolism: therapeutic implications for Alzheimer's disease.

Vardy ER, Catto AJ, Hooper NM.

Trends Mol Med. 2005 Oct;11(10):464-72. Review.

PMID:
16153892
19.

Prion protein (PrPc) promotes beta-amyloid plaque formation.

Schwarze-Eicker K, Keyvani K, Görtz N, Westaway D, Sachser N, Paulus W.

Neurobiol Aging. 2005 Aug-Sep;26(8):1177-82.

PMID:
15917101
20.

Amyloid beta peptide load is correlated with increased beta-secretase activity in sporadic Alzheimer's disease patients.

Li R, Lindholm K, Yang LB, Yue X, Citron M, Yan R, Beach T, Sue L, Sabbagh M, Cai H, Wong P, Price D, Shen Y.

Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3632-7.

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